Prognostic Implication of a Cuproptosis-Related miRNA Signature in Hepatocellular Carcinoma Article Swipe
Ze Jin
,
Mengmeng Wang
,
Yajun Meng
,
Di Chen
,
Yushuang Xu
,
Xin Jiang
,
Zhifan Xiong
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1155/2022/4694323
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1155/2022/4694323
Background. Hepatocellular carcinoma (HCC) is one of the most frequently diagnosed malignancies globally, accounting for the third cause of cancer mortality. Cuproptosis, a copper-induced cell death, was recently reported in Science. The purpose of this study was to evaluate the prognostic implication of cuproptosis-related miRNAs (CRMs) in HCC. Methods. Transcriptomic data and clinicopathological features of patients with HCC were extracted from the Cancer Genome Atlas (TCGA) database. Prognostic CRM signature was established by utilizing univariate Cox regression and LASSO analyses. To validate the accuracy of prediction, the Kaplan-Meier (K-M) and time-dependent receiver operating characteristic (ROC) analyses were adopted. A nomogram comprising clinical characteristics and the miRNA signature was developed to improve the prediction of patient outcomes. Finally, functional enrichment analysis and immune infiltration analysis were carried out. Results. Of CRMs, 14 were obtained to construct a prognostic miRNA signature. This CRM signature was an independent factor for predicting overall survival (OS). Kaplan-Meier curves demonstrated a noteworthy difference in survival rates between different risk subgroups ( p < 0.001 ). The robust prognostic capacity of this signature was exhibited by sampling verification and stratified survival analysis. Functional analysis indicated that the high-risk group was mainly enriched in signaling pathways and different levels of immune infiltration were revealed between the two risk groups. The potential interaction of the model with the immune checkpoint activities was also detected. Conclusion. The CRM signature could act as an independent predictor to guide individual treatment strategies, which could provide fundamental insights for further studies.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2022/4694323
- https://downloads.hindawi.com/journals/jhe/2022/4694323.pdf
- OA Status
- hybrid
- Cited By
- 11
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4295832047
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4295832047Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1155/2022/4694323Digital Object Identifier
- Title
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Prognostic Implication of a Cuproptosis-Related miRNA Signature in Hepatocellular CarcinomaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-09-13Full publication date if available
- Authors
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Ze Jin, Mengmeng Wang, Yajun Meng, Di Chen, Yushuang Xu, Xin Jiang, Zhifan XiongList of authors in order
- Landing page
-
https://doi.org/10.1155/2022/4694323Publisher landing page
- PDF URL
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https://downloads.hindawi.com/journals/jhe/2022/4694323.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://downloads.hindawi.com/journals/jhe/2022/4694323.pdfDirect OA link when available
- Concepts
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Hepatocellular carcinoma, microRNA, Signature (topology), Medicine, Oncology, Internal medicine, Pathology, Biology, Gene, Genetics, Mathematics, GeometryTop concepts (fields/topics) attached by OpenAlex
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11Total citation count in OpenAlex
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2025: 3, 2024: 1, 2023: 5, 2022: 2Per-year citation counts (last 5 years)
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52Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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