Prognostic utility of soluble ST2 biomarker in heart failure patients with reduced ejection fraction Article Swipe
Janardan Nimbolkar
,
Shubha Chogle
,
Rittu Chandel
,
Aruna Poojary
,
Shubhra Kar
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.18231/j.ijcbr.2022.005
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.18231/j.ijcbr.2022.005
sST2 is a member of interleukin 1 receptor family biomarker and the concentration of its soluble isoform increases with cardiac stress leading to cardiac fibrosis. It has 2 isoforms the ligand forms sST2L and soluble form. In acute or chronic heart failure the soluble form is highly prognostic and predictive of mortality. It’s a prospective study of patients aged 45 to 90 with reduced ejection fraction and cardiomyopathy. Sample collected for day 1,5,30. There outcome assessed at day 30 and mortality on one year follow up. Total 79 patients studied, 57 LVF cases and 22 healthy controls. 50 males, 29 females, Cardiomyopathy 24 cases. Mean sST2 value 137.7829±89 (SD). At 30 days outcome and one year mortality with significant P value 0.000. As the age increases sST2 levels rises. For cardiomyopathy patients sST2 (141±78). At day 5 and 30 patients improved with decrease in levels where worsened patients had persistent high values. Those patient with more than 250 or implausible values had worse outcome or expired. Most important those responded to appropriate treatment values significantly improved. For cardiomyopathy patients values remained high persistently and ultimately required cardiac transplant or definitive line of treatment. sST2 is diagnostic and prognostic marker in patients with HFrEF presenting as acute or chronic heart failure. Significant p values for 30 days outcome and mortality. In cardiomyopathy patients with persistent high levels were bad prognostic indicator and suggests consideration of definitive line of treatment.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18231/j.ijcbr.2022.005
- https://www.ijcbr.in/journal-article-file/16060
- OA Status
- diamond
- References
- 25
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4221006955Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.18231/j.ijcbr.2022.005Digital Object Identifier
- Title
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Prognostic utility of soluble ST2 biomarker in heart failure patients with reduced ejection fractionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-03-11Full publication date if available
- Authors
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Janardan Nimbolkar, Shubha Chogle, Rittu Chandel, Aruna Poojary, Shubhra KarList of authors in order
- Landing page
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https://doi.org/10.18231/j.ijcbr.2022.005Publisher landing page
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https://www.ijcbr.in/journal-article-file/16060Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://www.ijcbr.in/journal-article-file/16060Direct OA link when available
- Concepts
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Ejection fraction, Heart failure, Internal medicine, Biomarker, Cardiomyopathy, Cardiology, Medicine, Prospective cohort study, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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25Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.were | 226 |
| abstract_inverted_index.with | 18, 62, 117, 141, 154, 201, 222 |
| abstract_inverted_index.year | 83, 115 |
| abstract_inverted_index.(SD). | 108 |
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| abstract_inverted_index.There | 73 |
| abstract_inverted_index.Those | 152 |
| abstract_inverted_index.Total | 86 |
| abstract_inverted_index.acute | 37, 205 |
| abstract_inverted_index.cases | 92 |
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| abstract_inverted_index.value | 106, 120 |
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| abstract_inverted_index.worse | 162 |
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| abstract_inverted_index.levels | 127, 144, 225 |
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| abstract_inverted_index.males, | 98 |
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| abstract_inverted_index.member | 3 |
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| abstract_inverted_index.stress | 20 |
| abstract_inverted_index.values | 160, 173, 179, 212 |
| abstract_inverted_index.1,5,30. | 72 |
| abstract_inverted_index.cardiac | 19, 23, 186 |
| abstract_inverted_index.chronic | 39, 207 |
| abstract_inverted_index.failure | 41 |
| abstract_inverted_index.healthy | 95 |
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| abstract_inverted_index.leading | 21 |
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| abstract_inverted_index.soluble | 15, 34, 43 |
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| abstract_inverted_index.expired. | 165 |
| abstract_inverted_index.failure. | 209 |
| abstract_inverted_index.females, | 100 |
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| abstract_inverted_index.controls. | 96 |
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| abstract_inverted_index.improved. | 175 |
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| abstract_inverted_index.treatment | 172 |
| abstract_inverted_index.(141±78). | 133 |
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| abstract_inverted_index.diagnostic | 195 |
| abstract_inverted_index.mortality. | 51, 218 |
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| abstract_inverted_index.cardiomyopathy. | 67 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5014883673 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I2800671109 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8899999856948853 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.03068729 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |