Prognostic value and outcome for acute lymphocytic leukemia in children with MLL rearrangement: a case-control study Article Swipe
Kun‐yin Qiu
,
Dun‐hua Zhou
,
Xiong‐yu Liao
,
Ke Huang
,
Yang Li
,
Hong‐Gui Xu
,
Wen‐Jun Weng
,
Lu‐Hong Xu
,
Jian‐Pei Fang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1186/s12885-022-10378-w
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1186/s12885-022-10378-w
Purpose To evaluate the prognostic factors and outcome for acute lymphoblastic leukemia (ALL) in children with MLL rearrangement (MLL-r). Methods A total of 124 pediatric patients who were diagnosed with ALL were classified into two groups based on the MLL-r status by using a retrospective case-control study method from June 2008 to June 2020. Results The prevalence of MLL-r positive in the whole cohort was 4.9%. The complete remission (CR) rate on Day 33 in the MLL-r positive group was not statistically different from the negative group (96.8% vs 97.8%, P = 0.736). Multivariate analysis showed that T-cell, white blood cell counts (WBC) ≥ 50 × 10 9 /L, MLL-AF4, and D15 minimal residual disease (MRD) positive were independent risk factors affecting the prognosis of MLL-r positive children. Stem cell transplantation (SCT) was a favorable independent prognostic factor affecting event-free survival (EFS) in MLL-r positive patients ( P = 0.027), and there was a trend toward an independent prognostic effect on overall survival (OS) ( P = 0.065). The 10-year predicted EFS for patients with MLL-AF4, MLL-PTD, MLL-ENL, other MLL partner genes, and MLL-r negative cases were 46.67 ± 28.61%, 85.71 ± 22.37%, 75 ± 32.41%, 75 ± 32.41%, and 77.33 ± 10.81%, respectively ( P = 0.048). The 10-year predicted OS were 46.67 ± 28.61%, 85.71 ± 22.37%, 75 ± 32.41%, 75 ± 32.41%, and 85.2 ± 9.77%, respectively ( P = 0.049). The 124 patients with ALL were followed up and eventually 5 (4%) cases relapsed, with a median relapse time of 3.9 years. Conclusion Patients with MLL-r positive ALL have moderate remission rates, but are prone to relapse with low overall survival. The outcome of MLL-r positive ALL was closely related to the partner genes, and clinical attention should be paid to screening for MLL partner genes and combining them with other prognostic factors for accurate risk stratification.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12885-022-10378-w
- https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-022-10378-w
- OA Status
- gold
- Cited By
- 15
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4310786231
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4310786231Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s12885-022-10378-wDigital Object Identifier
- Title
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Prognostic value and outcome for acute lymphocytic leukemia in children with MLL rearrangement: a case-control studyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-12-02Full publication date if available
- Authors
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Kun‐yin Qiu, Dun‐hua Zhou, Xiong‐yu Liao, Ke Huang, Yang Li, Hong‐Gui Xu, Wen‐Jun Weng, Lu‐Hong Xu, Jian‐Pei FangList of authors in order
- Landing page
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https://doi.org/10.1186/s12885-022-10378-wPublisher landing page
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https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-022-10378-wDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-022-10378-wDirect OA link when available
- Concepts
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Internal medicine, Medicine, Gastroenterology, White blood cell, Lymphoblastic Leukemia, Multivariate analysis, Minimal residual disease, Acute leukemia, Retrospective cohort study, Leukemia, OncologyTop concepts (fields/topics) attached by OpenAlex
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15Total citation count in OpenAlex
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2025: 5, 2024: 5, 2023: 5Per-year citation counts (last 5 years)
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24Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.0.049). | 234 |
| abstract_inverted_index.0.065). | 168 |
| abstract_inverted_index.0.736). | 93 |
| abstract_inverted_index.10-year | 170, 210 |
| abstract_inverted_index.10.81%, | 203 |
| abstract_inverted_index.22.37%, | 193, 219 |
| abstract_inverted_index.28.61%, | 190, 216 |
| abstract_inverted_index.32.41%, | 196, 199, 222, 225 |
| abstract_inverted_index.Methods | 20 |
| abstract_inverted_index.Purpose | 1 |
| abstract_inverted_index.Results | 55 |
| abstract_inverted_index.T-cell, | 98 |
| abstract_inverted_index.closely | 283 |
| abstract_inverted_index.disease | 115 |
| abstract_inverted_index.factors | 6, 121, 307 |
| abstract_inverted_index.minimal | 113 |
| abstract_inverted_index.outcome | 8, 277 |
| abstract_inverted_index.overall | 162, 274 |
| abstract_inverted_index.partner | 181, 287, 299 |
| abstract_inverted_index.relapse | 252, 271 |
| abstract_inverted_index.related | 284 |
| abstract_inverted_index.(MLL-r). | 19 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.MLL-AF4, | 110, 176 |
| abstract_inverted_index.MLL-ENL, | 178 |
| abstract_inverted_index.MLL-PTD, | 177 |
| abstract_inverted_index.Patients | 258 |
| abstract_inverted_index.accurate | 309 |
| abstract_inverted_index.analysis | 95 |
| abstract_inverted_index.children | 15 |
| abstract_inverted_index.clinical | 290 |
| abstract_inverted_index.complete | 68 |
| abstract_inverted_index.evaluate | 3 |
| abstract_inverted_index.followed | 241 |
| abstract_inverted_index.leukemia | 12 |
| abstract_inverted_index.moderate | 264 |
| abstract_inverted_index.negative | 86, 185 |
| abstract_inverted_index.patients | 26, 146, 174, 237 |
| abstract_inverted_index.positive | 60, 78, 117, 127, 145, 261, 280 |
| abstract_inverted_index.residual | 114 |
| abstract_inverted_index.survival | 141, 163 |
| abstract_inverted_index.affecting | 122, 139 |
| abstract_inverted_index.attention | 291 |
| abstract_inverted_index.children. | 128 |
| abstract_inverted_index.combining | 302 |
| abstract_inverted_index.diagnosed | 29 |
| abstract_inverted_index.different | 83 |
| abstract_inverted_index.favorable | 135 |
| abstract_inverted_index.pediatric | 25 |
| abstract_inverted_index.predicted | 171, 211 |
| abstract_inverted_index.prognosis | 124 |
| abstract_inverted_index.relapsed, | 248 |
| abstract_inverted_index.remission | 69, 265 |
| abstract_inverted_index.screening | 296 |
| abstract_inverted_index.survival. | 275 |
| abstract_inverted_index.Conclusion | 257 |
| abstract_inverted_index.classified | 33 |
| abstract_inverted_index.event-free | 140 |
| abstract_inverted_index.eventually | 244 |
| abstract_inverted_index.prevalence | 57 |
| abstract_inverted_index.prognostic | 5, 137, 159, 306 |
| abstract_inverted_index.independent | 119, 136, 158 |
| abstract_inverted_index.Multivariate | 94 |
| abstract_inverted_index.case-control | 46 |
| abstract_inverted_index.respectively | 204, 230 |
| abstract_inverted_index.lymphoblastic | 11 |
| abstract_inverted_index.rearrangement | 18 |
| abstract_inverted_index.retrospective | 45 |
| abstract_inverted_index.statistically | 82 |
| abstract_inverted_index.stratification. | 311 |
| abstract_inverted_index.transplantation | 131 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7200000286102295 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.91662217 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |