Prognostic value of left atrial strain in patients with congenital aortic stenosis Article Swipe
Ferit Onur Mutluer
,
Daniel J. Bowen
,
Roderick W. J. van Grootel
,
Isabella Kardys
,
Jolien W. Roos‐Hesselink
,
Annemien E. van den Bosch
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/ehjopen/oeac023
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/ehjopen/oeac023
Aim To explore whether left atrial (LA) strain with speckle tracking echocardiography (STE) can contribute to prognostication in patients with congenital aortic stenosis (CAS). Methods and results In this prospective study, consecutive outpatients with stable CAS and healthy adults were enrolled between 2011 and 2015. Left atrial function was analysed with STE using Tomtec software. Associations between LA strain (LAS) measurements and primary composite outcome (any adverse cardiovascular event, hospitalization, or re-intervention) and secondary outcome (re-interventions) were assessed with Cox regression analysis. In total, 98 patients with CAS (mean age: 35.0 ± 11.9 year, female: 59.2%) and 121 controls (age: 43.9 ± 13.8 year, female: 55.4%) were included. The majority of patients were in NYHA class I: 97 (99%) at baseline. At baseline, LA conduit strain (LAS-cd) and strain rate (LASR-cd) were significantly lower in patients than in controls when corrected for age and sex (−18.1 ± 8.7 vs. −23.5 ± 9.9%, P = 0.001 and −0.73 ± 0.31 vs. −1.02 ± 0.43/s, P < 0.001). During a median follow-up of 6.4 years (5.7–7.1), the primary composite outcome occurred in 48 (39.6%) patients. Kaplan–Meier analysis showed that decreased LAS-cd (<21%) was associated with a higher occurrence of the primary outcome (log-rank: P = 0.008). Depressed LAS-cd and LASR-cd were both associated with the primary composite outcome [univariable hazard ratio (HR) = 0.64(0.46–0.88), P = 0.005 and HR = 0.68(0.55–0.83), P < 0.001, respectively]; adjusted HR (for LAS-cd and LASR-cd, respectively): 0.31(0.09–1.04), P = 0.06 and 0.49(0.26–0.89), P = 0.02. Conclusion Impairment in LA conduit function assessed with STE carries prognostic value in patients with CAS and can be implemented in clinical management.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ehjopen/oeac023
- https://academic.oup.com/ehjopen/article-pdf/2/3/oeac023/44157029/oeac023.pdf
- OA Status
- gold
- Cited By
- 15
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4224274224
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4224274224Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/ehjopen/oeac023Digital Object Identifier
- Title
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Prognostic value of left atrial strain in patients with congenital aortic stenosisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-04-06Full publication date if available
- Authors
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Ferit Onur Mutluer, Daniel J. Bowen, Roderick W. J. van Grootel, Isabella Kardys, Jolien W. Roos‐Hesselink, Annemien E. van den BoschList of authors in order
- Landing page
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https://doi.org/10.1093/ehjopen/oeac023Publisher landing page
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https://academic.oup.com/ehjopen/article-pdf/2/3/oeac023/44157029/oeac023.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://academic.oup.com/ehjopen/article-pdf/2/3/oeac023/44157029/oeac023.pdfDirect OA link when available
- Concepts
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Medicine, Internal medicine, Hazard ratio, Cardiology, Proportional hazards model, Stenosis, Prospective cohort study, Log-rank test, Asymptomatic, Confidence intervalTop concepts (fields/topics) attached by OpenAlex
- Cited by
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15Total citation count in OpenAlex
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2025: 2, 2024: 4, 2023: 7, 2022: 2Per-year citation counts (last 5 years)
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22Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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