Prognostic Value of RUNX1 Mutations in AML: A Meta-Analysis Article Swipe
Mahdi Jalili
,
Marjan Yaghmaie
,
Mohammad Ahmadvand
,
Kamran Alimoghaddam
,
Seyed Asadollah Mousavi
,
Mohammad Vaezi
,
Ardeshir Ghavamzadeh
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.22034/apjcp.2018.19.2.325
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.22034/apjcp.2018.19.2.325
The RUNX1 (AML1) gene is a relatively infrequent mutational target in cases of acute myeloid leukemia (AML). Previous work indicated that RUNX1 mutations can have pathological and prognostic implications. To evaluate prognostic value, we conducted a meta-analysis of 4 previous published works with data for survival according to RUNX1 mutation status. Pooled hazard ratios for overall survival and disease-free survival were 1.55 (95% confidence interval (CI) = 1.11–2.15; p-value = 0.01) and 1.76 (95% CI = 1.24–2.52; p-value = 0.002), respectively, for cases positive for RUNX1 mutations. This evidence supports clinical implications of RUNX1 mutations in the development and progression of AML cases and points to the possibility of a distinct category within the newer WHO classification. Though it must be kept in mind that the present work was based on data extracted from observational studies, the findings suggest that the RUNX1 status can contribute to risk-stratification and decision-making in management of AML.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://pubmed.ncbi.nlm.nih.gov/29479958
- OA Status
- green
- Cited By
- 31
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2782749804
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2782749804Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.22034/apjcp.2018.19.2.325Digital Object Identifier
- Title
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Prognostic Value of RUNX1 Mutations in AML: A Meta-AnalysisWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-02-26Full publication date if available
- Authors
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Mahdi Jalili, Marjan Yaghmaie, Mohammad Ahmadvand, Kamran Alimoghaddam, Seyed Asadollah Mousavi, Mohammad Vaezi, Ardeshir GhavamzadehList of authors in order
- Landing page
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https://pubmed.ncbi.nlm.nih.gov/29479958Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/5980915Direct OA link when available
- Concepts
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Hazard ratio, Confidence interval, Oncology, Internal medicine, RUNX1, Myeloid leukemia, Medicine, Meta-analysis, Pathological, Leukemia, Disease, Gene mutation, Mutation, Gene, Biology, Genetics, Transcription factorTop concepts (fields/topics) attached by OpenAlex
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31Total citation count in OpenAlex
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2025: 2, 2024: 5, 2023: 6, 2022: 4, 2021: 5Per-year citation counts (last 5 years)
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19Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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