Prognostic Value of Skeletal Muscle Loss in Patients with Hepatocellular Carcinoma Treated with Hepatic Arterial Infusion Chemotherapy Article Swipe
Kyoko Oura
,
Asahiro Morishita
,
Joji Tani
,
Takako Nomura
,
Takushi Manabe
,
Kei Takuma
,
M. Nakahara
,
Tomoko Tadokoro
,
Koji Fujita
,
Shima Mimura
,
Takayuki Sanomura
,
Yoshihiro Nishiyama
,
Tsutomu Masaki
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/cancers15061834
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/cancers15061834
Sarcopenia-related factors, including the skeletal muscle index (SMI), are reportedly associated with prognosis in patients with hepatocellular carcinoma (HCC) receiving various treatments. However, there is no evidence relating to hepatic arterial infusion chemotherapy (HAIC). In this study, we investigated whether a low SMI was associated with worse clinical outcomes of HAIC. Seventy patients with advanced HCC were included. Clinical outcomes were compared between the decreased SMI (n = 27) and non-decreased SMI (n = 43) groups, which were classified according to changes in the SMI after 3 weeks of treatment. In the prognostic analysis, patients in the decreased SMI group had significantly shorter progression-free and overall survival (OS) than those in the non-decreased SMI group. In addition, poor nutritional status and liver function were associated with an immediate decrease in the SMI after HAIC. The therapeutic effect was worse in the decreased SMI group than in the non-decreased SMI group, although the incidence of adverse events did not significantly differ. In multivariate analysis, a decreased SMI at 3 weeks after HAIC was identified as a significant independent factor associated with OS. A decreased SMI in patients with advanced HCC undergoing HAIC was associated with poor prognosis. It is effective to monitor the SMI to evaluate general conditions and predict clinical outcomes.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers15061834
- https://www.mdpi.com/2072-6694/15/6/1834/pdf?version=1679119856
- OA Status
- gold
- Cited By
- 4
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4327968444
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4327968444Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cancers15061834Digital Object Identifier
- Title
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Prognostic Value of Skeletal Muscle Loss in Patients with Hepatocellular Carcinoma Treated with Hepatic Arterial Infusion ChemotherapyWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-03-18Full publication date if available
- Authors
-
Kyoko Oura, Asahiro Morishita, Joji Tani, Takako Nomura, Takushi Manabe, Kei Takuma, M. Nakahara, Tomoko Tadokoro, Koji Fujita, Shima Mimura, Takayuki Sanomura, Yoshihiro Nishiyama, Tsutomu MasakiList of authors in order
- Landing page
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https://doi.org/10.3390/cancers15061834Publisher landing page
- PDF URL
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https://www.mdpi.com/2072-6694/15/6/1834/pdf?version=1679119856Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2072-6694/15/6/1834/pdf?version=1679119856Direct OA link when available
- Concepts
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Medicine, Hepatocellular carcinoma, Sarcopenia, Internal medicine, Adverse effect, Gastroenterology, Incidence (geometry), Multivariate analysis, Chemotherapy, Liver function, Oncology, Optics, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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45Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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