Programmable droplet microfluidics for complex multistep bioassays Article Swipe
Enqi Huang
,
Yu Wang
,
Dongyang Cai
,
Dayu Liu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/inmd.20230026
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/inmd.20230026
Programmable droplet microfluidics (PDM) refers to a microfluidic device that integrates the functionality of a series of droplets with distinct spatial locations in a designated temporal order. PDM streamlines the intricate workflow of complex bioassays by enabling programmable and macroscopic droplet displacements, in which the droplets serve as reservoirs for reagents, microvalves for liquid insulation, and in some cases micropumps for mass transportation. As these droplets are intangible structures, the need for expensive microfabrication procedures is eliminated. Furthermore, the parallelization of the droplet series provides flexibility in controlling the throughput of the microfluidic analysis system. This paper provides a comprehensive review of PDMs enabled by various microfluidic mechanisms, including magnetism actuation, relative liquid displacement, capillary suction and sequential microdisplacement. Additionally, important applications of PDM systems for nucleic acid detection, immunoassay, drug testing, and sample recovery are also introduced. In conclusion, PDM demonstrates its potential as a highly advantageous tool for executing intricate multistep bioassays on a microfluidic platform. These technologies have exhibited superiority over their traditional counterparts in terms of size reduction, automation, and low sample/reagent consumption.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/inmd.20230026
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/INMD.20230026
- OA Status
- diamond
- Cited By
- 9
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390767644
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390767644Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/inmd.20230026Digital Object Identifier
- Title
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Programmable droplet microfluidics for complex multistep bioassaysWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-01Full publication date if available
- Authors
-
Enqi Huang, Yu Wang, Dongyang Cai, Dayu LiuList of authors in order
- Landing page
-
https://doi.org/10.1002/inmd.20230026Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/INMD.20230026Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/INMD.20230026Direct OA link when available
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Microfluidics, Microfabrication, Nanotechnology, Computer science, Flexibility (engineering), Automation, Capillary action, Materials science, Engineering, Mechanical engineering, Medicine, Mathematics, Alternative medicine, Pathology, Composite material, Fabrication, StatisticsTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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66Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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