Accelerators, such as GPUs and Intel Xeon Phis, have become the workhorses of high-performance computing. Typically, the accelerators act as co-processors, with discrete memory spaces. They possess massive parallelism, along with many other unique architectural features. In order to obtain high performance, these features must be carefully exploited, which requires high programmer expertise. This thesis presents new programming models, and the necessary compiler and runtime systems to ease the accelerator programm…