Progress toward approval of an HCV vaccine Article Swipe
John LM Law
,
Mike Logan
,
Amir Landi
,
D. Lorne Tyrrell
,
Michael Houghton
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3138/canlivj.2018.0010
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3138/canlivj.2018.0010
New effective drugs to treat hepatitis C (HCV) promise to cure nearly all patients, but relying solely on antivirals without an effective vaccine has been ineffective in eliminating all other infectious diseases. A prophylactic HCV vaccine needs to be developed. Along with increased screening and drug coverage, an effective vaccine could make it possible to meet the World Health Organization’s target to eliminate HCV by 2030. On the basis of recent knowledge of immune correlates of protection combined with the demonstrated immunogenicity and protective animal efficacies of various HCV vaccine candidates, there is a possibility that a prophylactic HCV vaccine is on the horizon. This article summarizes the current status of a prophylactic HCV vaccine. Elicitation of cross-neutralizing antibodies and broad cellular immune responses are likely needed to overcome this highly diverse virus.
Related Topics
Metadata
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- https://doi.org/10.3138/canlivj.2018.0010
- OA Status
- green
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- 2
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- 50
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2891784449Canonical identifier for this work in OpenAlex
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https://doi.org/10.3138/canlivj.2018.0010Digital Object Identifier
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Progress toward approval of an HCV vaccineWork title
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reviewOpenAlex work type
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enPrimary language
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2018Year of publication
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2018-10-01Full publication date if available
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John LM Law, Mike Logan, Amir Landi, D. Lorne Tyrrell, Michael HoughtonList of authors in order
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https://doi.org/10.3138/canlivj.2018.0010Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/9203156Direct OA link when available
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Virology, MedicineTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2024: 1, 2022: 1Per-year citation counts (last 5 years)
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50Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.diseases. | 31 |
| abstract_inverted_index.effective | 1, 21, 48 |
| abstract_inverted_index.eliminate | 62 |
| abstract_inverted_index.hepatitis | 5 |
| abstract_inverted_index.increased | 42 |
| abstract_inverted_index.knowledge | 71 |
| abstract_inverted_index.patients, | 13 |
| abstract_inverted_index.responses | 123 |
| abstract_inverted_index.screening | 43 |
| abstract_inverted_index.antibodies | 118 |
| abstract_inverted_index.antivirals | 18 |
| abstract_inverted_index.correlates | 74 |
| abstract_inverted_index.developed. | 39 |
| abstract_inverted_index.efficacies | 85 |
| abstract_inverted_index.infectious | 30 |
| abstract_inverted_index.protection | 76 |
| abstract_inverted_index.protective | 83 |
| abstract_inverted_index.summarizes | 106 |
| abstract_inverted_index.Elicitation | 115 |
| abstract_inverted_index.candidates, | 90 |
| abstract_inverted_index.eliminating | 27 |
| abstract_inverted_index.ineffective | 25 |
| abstract_inverted_index.possibility | 94 |
| abstract_inverted_index.demonstrated | 80 |
| abstract_inverted_index.prophylactic | 33, 97, 112 |
| abstract_inverted_index.immunogenicity | 81 |
| abstract_inverted_index.Organization’s | 59 |
| abstract_inverted_index.cross-neutralizing | 117 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5078770409 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I154425047 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.16504484 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |