Progress Towards a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine Article Swipe
Grace P. Ahlqvist
,
Catherine P. McGeough
,
Chris H. Senanayake
,
Joseph D. Armstrong
,
Ajay Yadaw
,
Sarabindu Roy
,
Saeed Ahmad
,
David Snead
,
Timothy F. Jamison
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv.13809527
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv.13809527
Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for treatment of COVID-19. Herein we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selective enzymatic acylation followed by transamination to yield the final drug product. Both steps have been successfully performed on decagram scale: the first step at 200 g, and the second step at 80 g. Overall, molnupiravir has been obtained in a 41% overall isolated yield compared to a maximum 17% isolated yield in the patented route. This route provides many advantages to the initial route described in the patent literature and would decrease the cost of this pharmaceutical should it prove safe and efficacious in ongoing clinical trials.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.26434/chemrxiv.13809527
- https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c754ff9abda2432ff8e284/original/progress-towards-a-large-scale-synthesis-of-molnupiravir-mk-4482-eidd-2801-from-cytidine.pdf
- OA Status
- gold
- References
- 10
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4232818755
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4232818755Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.26434/chemrxiv.13809527Digital Object Identifier
- Title
-
Progress Towards a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from CytidineWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-02-16Full publication date if available
- Authors
-
Grace P. Ahlqvist, Catherine P. McGeough, Chris H. Senanayake, Joseph D. Armstrong, Ajay Yadaw, Sarabindu Roy, Saeed Ahmad, David Snead, Timothy F. JamisonList of authors in order
- Landing page
-
https://doi.org/10.26434/chemrxiv.13809527Publisher landing page
- PDF URL
-
https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c754ff9abda2432ff8e284/original/progress-towards-a-large-scale-synthesis-of-molnupiravir-mk-4482-eidd-2801-from-cytidine.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c754ff9abda2432ff8e284/original/progress-towards-a-large-scale-synthesis-of-molnupiravir-mk-4482-eidd-2801-from-cytidine.pdfDirect OA link when available
- Concepts
-
Transamination, Yield (engineering), Cytidine, Chemistry, Drug, Combinatorial chemistry, Pharmacology, Medicine, Enzyme, Biochemistry, Materials science, MetallurgyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
10Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4232818755 |
|---|---|
| doi | https://doi.org/10.26434/chemrxiv.13809527 |
| ids.doi | https://doi.org/10.26434/chemrxiv.13809527 |
| ids.openalex | https://openalex.org/W4232818755 |
| fwci | |
| type | preprint |
| title | Progress Towards a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11845 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9929999709129333 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Cancer therapeutics and mechanisms |
| topics[1].id | https://openalex.org/T10526 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9891999959945679 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2725 |
| topics[1].subfield.display_name | Infectious Diseases |
| topics[1].display_name | HIV/AIDS drug development and treatment |
| topics[2].id | https://openalex.org/T10654 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9868000149726868 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Pneumonia and Respiratory Infections |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C68793091 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8391693234443665 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q603891 |
| concepts[0].display_name | Transamination |
| concepts[1].id | https://openalex.org/C134121241 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7341533899307251 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q899301 |
| concepts[1].display_name | Yield (engineering) |
| concepts[2].id | https://openalex.org/C2781184954 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6697629690170288 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q422538 |
| concepts[2].display_name | Cytidine |
| concepts[3].id | https://openalex.org/C185592680 |
| concepts[3].level | 0 |
| concepts[3].score | 0.4853631258010864 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[3].display_name | Chemistry |
| concepts[4].id | https://openalex.org/C2780035454 |
| concepts[4].level | 2 |
| concepts[4].score | 0.43708425760269165 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q8386 |
| concepts[4].display_name | Drug |
| concepts[5].id | https://openalex.org/C21951064 |
| concepts[5].level | 1 |
| concepts[5].score | 0.4006240963935852 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q899212 |
| concepts[5].display_name | Combinatorial chemistry |
| concepts[6].id | https://openalex.org/C98274493 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3796822428703308 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[6].display_name | Pharmacology |
| concepts[7].id | https://openalex.org/C71924100 |
| concepts[7].level | 0 |
| concepts[7].score | 0.2740979790687561 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[7].display_name | Medicine |
| concepts[8].id | https://openalex.org/C181199279 |
| concepts[8].level | 2 |
| concepts[8].score | 0.23100870847702026 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[8].display_name | Enzyme |
| concepts[9].id | https://openalex.org/C55493867 |
| concepts[9].level | 1 |
| concepts[9].score | 0.19579026103019714 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[9].display_name | Biochemistry |
| concepts[10].id | https://openalex.org/C192562407 |
| concepts[10].level | 0 |
| concepts[10].score | 0.1066516637802124 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[10].display_name | Materials science |
| concepts[11].id | https://openalex.org/C191897082 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11467 |
| concepts[11].display_name | Metallurgy |
| keywords[0].id | https://openalex.org/keywords/transamination |
| keywords[0].score | 0.8391693234443665 |
| keywords[0].display_name | Transamination |
| keywords[1].id | https://openalex.org/keywords/yield |
| keywords[1].score | 0.7341533899307251 |
| keywords[1].display_name | Yield (engineering) |
| keywords[2].id | https://openalex.org/keywords/cytidine |
| keywords[2].score | 0.6697629690170288 |
| keywords[2].display_name | Cytidine |
| keywords[3].id | https://openalex.org/keywords/chemistry |
| keywords[3].score | 0.4853631258010864 |
| keywords[3].display_name | Chemistry |
| keywords[4].id | https://openalex.org/keywords/drug |
| keywords[4].score | 0.43708425760269165 |
| keywords[4].display_name | Drug |
| keywords[5].id | https://openalex.org/keywords/combinatorial-chemistry |
| keywords[5].score | 0.4006240963935852 |
| keywords[5].display_name | Combinatorial chemistry |
| keywords[6].id | https://openalex.org/keywords/pharmacology |
| keywords[6].score | 0.3796822428703308 |
| keywords[6].display_name | Pharmacology |
| keywords[7].id | https://openalex.org/keywords/medicine |
| keywords[7].score | 0.2740979790687561 |
| keywords[7].display_name | Medicine |
| keywords[8].id | https://openalex.org/keywords/enzyme |
| keywords[8].score | 0.23100870847702026 |
| keywords[8].display_name | Enzyme |
| keywords[9].id | https://openalex.org/keywords/biochemistry |
| keywords[9].score | 0.19579026103019714 |
| keywords[9].display_name | Biochemistry |
| keywords[10].id | https://openalex.org/keywords/materials-science |
| keywords[10].score | 0.1066516637802124 |
| keywords[10].display_name | Materials science |
| language | en |
| locations[0].id | doi:10.26434/chemrxiv.13809527 |
| locations[0].is_oa | True |
| locations[0].source | |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c754ff9abda2432ff8e284/original/progress-towards-a-large-scale-synthesis-of-molnupiravir-mk-4482-eidd-2801-from-cytidine.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.26434/chemrxiv.13809527 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5064813076 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4410-7745 |
| authorships[0].author.display_name | Grace P. Ahlqvist |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I63966007 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, United States |
| authorships[0].institutions[0].id | https://openalex.org/I63966007 |
| authorships[0].institutions[0].ror | https://ror.org/042nb2s44 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I63966007 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Massachusetts Institute of Technology |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Grace P. Ahlqvist |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, United States |
| authorships[1].author.id | https://openalex.org/A5064291773 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Catherine P. McGeough |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I63966007 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, United States |
| authorships[1].institutions[0].id | https://openalex.org/I63966007 |
| authorships[1].institutions[0].ror | https://ror.org/042nb2s44 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I63966007 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Massachusetts Institute of Technology |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Catherine P. McGeough |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, United States |
| authorships[2].author.id | https://openalex.org/A5015397568 |
| authorships[2].author.orcid | https://orcid.org/0009-0009-3170-0687 |
| authorships[2].author.display_name | Chris H. Senanayake |
| authorships[2].affiliations[0].raw_affiliation_string | TCG GreenChem, Inc., Process R&D Center at Princeton South, 701 Charles Ewing Boulevard Ewing, NJ 08628, United States |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Chris Senanayake |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | TCG GreenChem, Inc., Process R&D Center at Princeton South, 701 Charles Ewing Boulevard Ewing, NJ 08628, United States |
| authorships[3].author.id | https://openalex.org/A5111861631 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Joseph D. Armstrong |
| authorships[3].affiliations[0].raw_affiliation_string | TCG GreenChem, Inc., Process R&D Center at Princeton South, 701 Charles Ewing Boulevard Ewing, NJ 08628, United States |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Joseph D. Armstrong |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | TCG GreenChem, Inc., Process R&D Center at Princeton South, 701 Charles Ewing Boulevard Ewing, NJ 08628, United States |
| authorships[4].author.id | https://openalex.org/A5111866205 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Ajay Yadaw |
| authorships[4].affiliations[0].raw_affiliation_string | TCG GreenChem, Inc., Process R&D Center at Princeton South, 701 Charles Ewing Boulevard Ewing, NJ 08628, United States |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ajay Yadaw |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | TCG GreenChem, Inc., Process R&D Center at Princeton South, 701 Charles Ewing Boulevard Ewing, NJ 08628, United States |
| authorships[5].author.id | https://openalex.org/A5078713873 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-0158-4963 |
| authorships[5].author.display_name | Sarabindu Roy |
| authorships[5].affiliations[0].raw_affiliation_string | TCG GreenChem, Inc., Process R&D Center at Princeton South, 701 Charles Ewing Boulevard Ewing, NJ 08628, United States |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Sarabindu Roy |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | TCG GreenChem, Inc., Process R&D Center at Princeton South, 701 Charles Ewing Boulevard Ewing, NJ 08628, United States |
| authorships[6].author.id | https://openalex.org/A5101587120 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-4187-2767 |
| authorships[6].author.display_name | Saeed Ahmad |
| authorships[6].affiliations[0].raw_affiliation_string | Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond, VA, United States |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Saeed Ahmad |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond, VA, United States |
| authorships[7].author.id | https://openalex.org/A5084778782 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-0766-9650 |
| authorships[7].author.display_name | David Snead |
| authorships[7].affiliations[0].raw_affiliation_string | Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond, VA, United States |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | David R. Snead |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Medicines for All Institute, 737 N. 5th St., Box 980100, Richmond, VA, United States |
| authorships[8].author.id | https://openalex.org/A5044333811 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-8601-7799 |
| authorships[8].author.display_name | Timothy F. Jamison |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I63966007 |
| authorships[8].affiliations[0].raw_affiliation_string | Massachusetts Institute of Technology |
| authorships[8].institutions[0].id | https://openalex.org/I63966007 |
| authorships[8].institutions[0].ror | https://ror.org/042nb2s44 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I63966007 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Massachusetts Institute of Technology |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Tim Jamison |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Massachusetts Institute of Technology |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c754ff9abda2432ff8e284/original/progress-towards-a-large-scale-synthesis-of-molnupiravir-mk-4482-eidd-2801-from-cytidine.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Progress Towards a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11845 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9929999709129333 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Cancer therapeutics and mechanisms |
| related_works | https://openalex.org/W3049730095, https://openalex.org/W110034027, https://openalex.org/W4252013364, https://openalex.org/W2092643113, https://openalex.org/W4211141996, https://openalex.org/W1963936792, https://openalex.org/W4244027253, https://openalex.org/W2892523202, https://openalex.org/W4231161935, https://openalex.org/W1974922378 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.26434/chemrxiv.13809527 |
| best_oa_location.is_oa | True |
| best_oa_location.source | |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c754ff9abda2432ff8e284/original/progress-towards-a-large-scale-synthesis-of-molnupiravir-mk-4482-eidd-2801-from-cytidine.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.26434/chemrxiv.13809527 |
| primary_location.id | doi:10.26434/chemrxiv.13809527 |
| primary_location.is_oa | True |
| primary_location.source | |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c754ff9abda2432ff8e284/original/progress-towards-a-large-scale-synthesis-of-molnupiravir-mk-4482-eidd-2801-from-cytidine.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.26434/chemrxiv.13809527 |
| publication_date | 2021-02-16 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2996975377, https://openalex.org/W2318320227, https://openalex.org/W1938116293, https://openalex.org/W4244399992, https://openalex.org/W2341916721, https://openalex.org/W3091362027, https://openalex.org/W3014708904, https://openalex.org/W2936946410, https://openalex.org/W3110209099, https://openalex.org/W2897191603 |
| referenced_works_count | 10 |
| abstract_inverted_index.a | 7, 20, 33, 74, 81 |
| abstract_inverted_index.80 | 66 |
| abstract_inverted_index.at | 58, 65 |
| abstract_inverted_index.by | 38 |
| abstract_inverted_index.g, | 60 |
| abstract_inverted_index.g. | 67 |
| abstract_inverted_index.in | 73, 86, 100, 118 |
| abstract_inverted_index.is | 6 |
| abstract_inverted_index.it | 113 |
| abstract_inverted_index.of | 15, 25, 30, 109 |
| abstract_inverted_index.on | 52 |
| abstract_inverted_index.to | 40, 80, 95 |
| abstract_inverted_index.we | 18 |
| abstract_inverted_index.17% | 83 |
| abstract_inverted_index.200 | 59 |
| abstract_inverted_index.41% | 75 |
| abstract_inverted_index.and | 22, 61, 104, 116 |
| abstract_inverted_index.for | 13 |
| abstract_inverted_index.has | 70 |
| abstract_inverted_index.the | 42, 55, 62, 87, 96, 101, 107 |
| abstract_inverted_index.two | 31 |
| abstract_inverted_index.Both | 46 |
| abstract_inverted_index.This | 90 |
| abstract_inverted_index.been | 49, 71 |
| abstract_inverted_index.cost | 108 |
| abstract_inverted_index.drug | 11, 44 |
| abstract_inverted_index.from | 27 |
| abstract_inverted_index.have | 48 |
| abstract_inverted_index.many | 93 |
| abstract_inverted_index.safe | 115 |
| abstract_inverted_index.step | 57, 64 |
| abstract_inverted_index.this | 110 |
| abstract_inverted_index.final | 43 |
| abstract_inverted_index.first | 56 |
| abstract_inverted_index.prove | 114 |
| abstract_inverted_index.route | 91, 98 |
| abstract_inverted_index.steps | 47 |
| abstract_inverted_index.would | 105 |
| abstract_inverted_index.yield | 41, 78, 85 |
| abstract_inverted_index.Herein | 17 |
| abstract_inverted_index.orally | 9 |
| abstract_inverted_index.patent | 102 |
| abstract_inverted_index.route. | 89 |
| abstract_inverted_index.scale: | 54 |
| abstract_inverted_index.second | 63 |
| abstract_inverted_index.should | 112 |
| abstract_inverted_index.steps: | 32 |
| abstract_inverted_index.initial | 97 |
| abstract_inverted_index.maximum | 82 |
| abstract_inverted_index.ongoing | 119 |
| abstract_inverted_index.overall | 76 |
| abstract_inverted_index.Overall, | 68 |
| abstract_inverted_index.clinical | 120 |
| abstract_inverted_index.compared | 79 |
| abstract_inverted_index.decagram | 53 |
| abstract_inverted_index.decrease | 106 |
| abstract_inverted_index.describe | 19 |
| abstract_inverted_index.followed | 37 |
| abstract_inverted_index.isolated | 77, 84 |
| abstract_inverted_index.obtained | 72 |
| abstract_inverted_index.patented | 88 |
| abstract_inverted_index.product. | 45 |
| abstract_inverted_index.provides | 92 |
| abstract_inverted_index.(MK-4482, | 4 |
| abstract_inverted_index.COVID-19. | 16 |
| abstract_inverted_index.acylation | 36 |
| abstract_inverted_index.candidate | 12 |
| abstract_inverted_index.cytidine, | 28 |
| abstract_inverted_index.described | 99 |
| abstract_inverted_index.enzymatic | 35 |
| abstract_inverted_index.performed | 51 |
| abstract_inverted_index.promising | 8 |
| abstract_inverted_index.selective | 34 |
| abstract_inverted_index.synthesis | 24 |
| abstract_inverted_index.treatment | 14 |
| abstract_inverted_index.EIDD-2801) | 5 |
| abstract_inverted_index.advantages | 94 |
| abstract_inverted_index.consisting | 29 |
| abstract_inverted_index.literature | 103 |
| abstract_inverted_index.<div> | 0, 1, 2 |
| abstract_inverted_index.efficacious | 117 |
| abstract_inverted_index.</div> | 122, 123, 124 |
| abstract_inverted_index.bioavailable | 10 |
| abstract_inverted_index.molnupiravir | 26, 69 |
| abstract_inverted_index.successfully | 50 |
| abstract_inverted_index.pharmaceutical | 111 |
| abstract_inverted_index.transamination | 39 |
| abstract_inverted_index.supply-centered | 21 |
| abstract_inverted_index.trials.</p> | 121 |
| abstract_inverted_index.chromatography-free | 23 |
| abstract_inverted_index.<p>Molnupiravir | 3 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.4399999976158142 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.1672148 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |