Progressive Myoclonic Epilepsy Type 1 (EPM1) Patients Present with Abnormal 1H MRS Brain Metabolic Profiles Associated with Cognitive Function Article Swipe

View

Jelena Hyppönen , Vili Paanila , Marja Äikiä , Päivi Koskenkorva , Mervi Könönen , Ritva Vanninen , Esa Mervaala , Reetta Kälviäinen , Juhana Hakumäki ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.2139/ssrn.4421467

Related Topics

Concepts

Epilepsy Progressive myoclonus epilepsy Brain function Myoclonic epilepsy Cognition Medicine Pediatrics Psychology Neuroscience Psychiatry

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.2139/ssrn.4421467
OA Status: green
Cited By: 1
Related Works: 10
OpenAlex ID: https://openalex.org/W4366957161

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4366957161

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.2139/ssrn.4421467

Digital Object Identifier
Title: Progressive Myoclonic Epilepsy Type 1 (EPM1) Patients Present with Abnormal 1H MRS Brain Metabolic Profiles Associated with Cognitive Function

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2023

Year of publication
Publication date: 2023-01-01

Full publication date if available
Authors: Jelena Hyppönen, Vili Paanila, Marja Äikiä, Päivi Koskenkorva, Mervi Könönen, Ritva Vanninen, Esa Mervaala, Reetta Kälviäinen, Juhana Hakumäki

List of authors in order
Landing page: https://doi.org/10.2139/ssrn.4421467

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: green

Open access status per OpenAlex
OA URL: https://doi.org/10.2139/ssrn.4421467

Direct OA link when available
Concepts: Epilepsy, Progressive myoclonus epilepsy, Brain function, Myoclonic epilepsy, Cognition, Medicine, Pediatrics, Psychology, Neuroscience, Psychiatry

Top concepts (fields/topics) attached by OpenAlex
Cited by: 1

Total citation count in OpenAlex
Citations by year (recent): 2025: 1

Per-year citation counts (last 5 years)
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4366957161
doi	https://doi.org/10.2139/ssrn.4421467
ids.doi	https://doi.org/10.2139/ssrn.4421467
ids.openalex	https://openalex.org/W4366957161
fwci	0.41037444
type	preprint
title	Progressive Myoclonic Epilepsy Type 1 (EPM1) Patients Present with Abnormal 1H MRS Brain Metabolic Profiles Associated with Cognitive Function
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T12604
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9976000189781189
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2745
topics[0].subfield.display_name	Rheumatology
topics[0].display_name	Glycogen Storage Diseases and Myoclonus
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2778186239
concepts[0].level	2
concepts[0].score	0.6235458850860596
concepts[0].wikidata	https://www.wikidata.org/wiki/Q41571
concepts[0].display_name	Epilepsy
concepts[1].id	https://openalex.org/C2781467325
concepts[1].level	3
concepts[1].score	0.5961615443229675
concepts[1].wikidata	https://www.wikidata.org/wiki/Q7248853
concepts[1].display_name	Progressive myoclonus epilepsy
concepts[2].id	https://openalex.org/C3018390542
concepts[2].level	2
concepts[2].score	0.5432054996490479
concepts[2].wikidata	https://www.wikidata.org/wiki/Q1073
concepts[2].display_name	Brain function
concepts[3].id	https://openalex.org/C2775859823
concepts[3].level	3
concepts[3].score	0.5407971739768982
concepts[3].wikidata	https://www.wikidata.org/wiki/Q11883686
concepts[3].display_name	Myoclonic epilepsy
concepts[4].id	https://openalex.org/C169900460
concepts[4].level	2
concepts[4].score	0.5318434238433838
concepts[4].wikidata	https://www.wikidata.org/wiki/Q2200417
concepts[4].display_name	Cognition
concepts[5].id	https://openalex.org/C71924100
concepts[5].level	0
concepts[5].score	0.46949222683906555
concepts[5].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[5].display_name	Medicine
concepts[6].id	https://openalex.org/C187212893
concepts[6].level	1
concepts[6].score	0.34229883551597595
concepts[6].wikidata	https://www.wikidata.org/wiki/Q123028
concepts[6].display_name	Pediatrics
concepts[7].id	https://openalex.org/C15744967
concepts[7].level	0
concepts[7].score	0.334983229637146
concepts[7].wikidata	https://www.wikidata.org/wiki/Q9418
concepts[7].display_name	Psychology
concepts[8].id	https://openalex.org/C169760540
concepts[8].level	1
concepts[8].score	0.24751624464988708
concepts[8].wikidata	https://www.wikidata.org/wiki/Q207011
concepts[8].display_name	Neuroscience
concepts[9].id	https://openalex.org/C118552586
concepts[9].level	1
concepts[9].score	0.23646560311317444
concepts[9].wikidata	https://www.wikidata.org/wiki/Q7867
concepts[9].display_name	Psychiatry
keywords[0].id	https://openalex.org/keywords/epilepsy
keywords[0].score	0.6235458850860596
keywords[0].display_name	Epilepsy
keywords[1].id	https://openalex.org/keywords/progressive-myoclonus-epilepsy
keywords[1].score	0.5961615443229675
keywords[1].display_name	Progressive myoclonus epilepsy
keywords[2].id	https://openalex.org/keywords/brain-function
keywords[2].score	0.5432054996490479
keywords[2].display_name	Brain function
keywords[3].id	https://openalex.org/keywords/myoclonic-epilepsy
keywords[3].score	0.5407971739768982
keywords[3].display_name	Myoclonic epilepsy
keywords[4].id	https://openalex.org/keywords/cognition
keywords[4].score	0.5318434238433838
keywords[4].display_name	Cognition
keywords[5].id	https://openalex.org/keywords/medicine
keywords[5].score	0.46949222683906555
keywords[5].display_name	Medicine
keywords[6].id	https://openalex.org/keywords/pediatrics
keywords[6].score	0.34229883551597595
keywords[6].display_name	Pediatrics
keywords[7].id	https://openalex.org/keywords/psychology
keywords[7].score	0.334983229637146
keywords[7].display_name	Psychology
keywords[8].id	https://openalex.org/keywords/neuroscience
keywords[8].score	0.24751624464988708
keywords[8].display_name	Neuroscience
keywords[9].id	https://openalex.org/keywords/psychiatry
keywords[9].score	0.23646560311317444
keywords[9].display_name	Psychiatry
language	en
locations[0].id	doi:10.2139/ssrn.4421467
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4210172589
locations[0].source.issn	1556-5068
locations[0].source.type	repository
locations[0].source.is_oa	True
locations[0].source.issn_l	1556-5068
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	SSRN Electronic Journal
locations[0].source.host_organization	https://openalex.org/I1318003438
locations[0].source.host_organization_name	RELX Group (Netherlands)
locations[0].source.host_organization_lineage	https://openalex.org/I1318003438
locations[0].license
locations[0].pdf_url
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.2139/ssrn.4421467
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5069103960
authorships[0].author.orcid	https://orcid.org/0000-0003-3027-9340
authorships[0].author.display_name	Jelena Hyppönen
authorships[0].countries	FI
authorships[0].affiliations[0].institution_ids	https://openalex.org/I4210092991
authorships[0].affiliations[0].raw_affiliation_string	Kuopio University Hospital
authorships[0].institutions[0].id	https://openalex.org/I4210092991
authorships[0].institutions[0].ror	https://ror.org/00fqdfs68
authorships[0].institutions[0].type	healthcare
authorships[0].institutions[0].lineage	https://openalex.org/I4210092991
authorships[0].institutions[0].country_code	FI
authorships[0].institutions[0].display_name	Kuopio University Hospital
authorships[0].author_position	first
authorships[0].raw_author_name	Jelena Hyppönen
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Kuopio University Hospital
authorships[1].author.id	https://openalex.org/A5004527449
authorships[1].author.orcid
authorships[1].author.display_name	Vili Paanila
authorships[1].countries	FI
authorships[1].affiliations[0].institution_ids	https://openalex.org/I4210092991
authorships[1].affiliations[0].raw_affiliation_string	Kuopio University Hospital
authorships[1].institutions[0].id	https://openalex.org/I4210092991
authorships[1].institutions[0].ror	https://ror.org/00fqdfs68
authorships[1].institutions[0].type	healthcare
authorships[1].institutions[0].lineage	https://openalex.org/I4210092991
authorships[1].institutions[0].country_code	FI
authorships[1].institutions[0].display_name	Kuopio University Hospital
authorships[1].author_position	middle
authorships[1].raw_author_name	Vili Paanila
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Kuopio University Hospital
authorships[2].author.id	https://openalex.org/A5055398576
authorships[2].author.orcid
authorships[2].author.display_name	Marja Äikiä
authorships[2].countries	FI
authorships[2].affiliations[0].institution_ids	https://openalex.org/I4210092991
authorships[2].affiliations[0].raw_affiliation_string	Kuopio University Hospital
authorships[2].institutions[0].id	https://openalex.org/I4210092991
authorships[2].institutions[0].ror	https://ror.org/00fqdfs68
authorships[2].institutions[0].type	healthcare
authorships[2].institutions[0].lineage	https://openalex.org/I4210092991
authorships[2].institutions[0].country_code	FI
authorships[2].institutions[0].display_name	Kuopio University Hospital
authorships[2].author_position	middle
authorships[2].raw_author_name	Marja Äikiä
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Kuopio University Hospital
authorships[3].author.id	https://openalex.org/A5029127894
authorships[3].author.orcid
authorships[3].author.display_name	Päivi Koskenkorva
authorships[3].countries	FI
authorships[3].affiliations[0].institution_ids	https://openalex.org/I4210092991
authorships[3].affiliations[0].raw_affiliation_string	Kuopio University Hospital
authorships[3].institutions[0].id	https://openalex.org/I4210092991
authorships[3].institutions[0].ror	https://ror.org/00fqdfs68
authorships[3].institutions[0].type	healthcare
authorships[3].institutions[0].lineage	https://openalex.org/I4210092991
authorships[3].institutions[0].country_code	FI
authorships[3].institutions[0].display_name	Kuopio University Hospital
authorships[3].author_position	middle
authorships[3].raw_author_name	Päivi Koskenkorva
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Kuopio University Hospital
authorships[4].author.id	https://openalex.org/A5054389377
authorships[4].author.orcid	https://orcid.org/0000-0002-9622-2796
authorships[4].author.display_name	Mervi Könönen
authorships[4].countries	FI
authorships[4].affiliations[0].institution_ids	https://openalex.org/I4210092991
authorships[4].affiliations[0].raw_affiliation_string	Kuopio University Hospital
authorships[4].institutions[0].id	https://openalex.org/I4210092991
authorships[4].institutions[0].ror	https://ror.org/00fqdfs68
authorships[4].institutions[0].type	healthcare
authorships[4].institutions[0].lineage	https://openalex.org/I4210092991
authorships[4].institutions[0].country_code	FI
authorships[4].institutions[0].display_name	Kuopio University Hospital
authorships[4].author_position	middle
authorships[4].raw_author_name	Mervi Könönen
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Kuopio University Hospital
authorships[5].author.id	https://openalex.org/A5026546218
authorships[5].author.orcid	https://orcid.org/0000-0003-2423-9350
authorships[5].author.display_name	Ritva Vanninen
authorships[5].countries	FI
authorships[5].affiliations[0].institution_ids	https://openalex.org/I4210092991
authorships[5].affiliations[0].raw_affiliation_string	Kuopio University Hospital
authorships[5].institutions[0].id	https://openalex.org/I4210092991
authorships[5].institutions[0].ror	https://ror.org/00fqdfs68
authorships[5].institutions[0].type	healthcare
authorships[5].institutions[0].lineage	https://openalex.org/I4210092991
authorships[5].institutions[0].country_code	FI
authorships[5].institutions[0].display_name	Kuopio University Hospital
authorships[5].author_position	middle
authorships[5].raw_author_name	Ritva Vanninen
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Kuopio University Hospital
authorships[6].author.id	https://openalex.org/A5090552786
authorships[6].author.orcid	https://orcid.org/0000-0001-5682-5747
authorships[6].author.display_name	Esa Mervaala
authorships[6].countries	FI
authorships[6].affiliations[0].institution_ids	https://openalex.org/I4210092991
authorships[6].affiliations[0].raw_affiliation_string	Kuopio University Hospital
authorships[6].institutions[0].id	https://openalex.org/I4210092991
authorships[6].institutions[0].ror	https://ror.org/00fqdfs68
authorships[6].institutions[0].type	healthcare
authorships[6].institutions[0].lineage	https://openalex.org/I4210092991
authorships[6].institutions[0].country_code	FI
authorships[6].institutions[0].display_name	Kuopio University Hospital
authorships[6].author_position	middle
authorships[6].raw_author_name	Esa Mervaala
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Kuopio University Hospital
authorships[7].author.id	https://openalex.org/A5025493981
authorships[7].author.orcid	https://orcid.org/0000-0003-2935-5131
authorships[7].author.display_name	Reetta Kälviäinen
authorships[7].countries	FI
authorships[7].affiliations[0].institution_ids	https://openalex.org/I4210092991
authorships[7].affiliations[0].raw_affiliation_string	Kuopio University Hospital
authorships[7].institutions[0].id	https://openalex.org/I4210092991
authorships[7].institutions[0].ror	https://ror.org/00fqdfs68
authorships[7].institutions[0].type	healthcare
authorships[7].institutions[0].lineage	https://openalex.org/I4210092991
authorships[7].institutions[0].country_code	FI
authorships[7].institutions[0].display_name	Kuopio University Hospital
authorships[7].author_position	middle
authorships[7].raw_author_name	Reetta Kälviäinen
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	Kuopio University Hospital
authorships[8].author.id	https://openalex.org/A5019394194
authorships[8].author.orcid	https://orcid.org/0000-0001-7341-5440
authorships[8].author.display_name	Juhana Hakumäki
authorships[8].countries	FI
authorships[8].affiliations[0].institution_ids	https://openalex.org/I175532246, https://openalex.org/I4210107997, https://openalex.org/I4389424196
authorships[8].affiliations[0].raw_affiliation_string	University of Eastern Finland - Institute of Clinical Medicine
authorships[8].institutions[0].id	https://openalex.org/I4389424196
authorships[8].institutions[0].ror
authorships[8].institutions[0].type
authorships[8].institutions[0].lineage	https://openalex.org/I4389424196
authorships[8].institutions[0].country_code
authorships[8].institutions[0].display_name	Deleted Institution
authorships[8].institutions[1].id	https://openalex.org/I4210107997
authorships[8].institutions[1].ror	https://ror.org/014rks409
authorships[8].institutions[1].type	education
authorships[8].institutions[1].lineage	https://openalex.org/I4210107997
authorships[8].institutions[1].country_code	FI
authorships[8].institutions[1].display_name	Finland University
authorships[8].institutions[2].id	https://openalex.org/I175532246
authorships[8].institutions[2].ror	https://ror.org/00cyydd11
authorships[8].institutions[2].type	education
authorships[8].institutions[2].lineage	https://openalex.org/I175532246
authorships[8].institutions[2].country_code	FI
authorships[8].institutions[2].display_name	University of Eastern Finland
authorships[8].author_position	last
authorships[8].raw_author_name	Juhana Hakumäki
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	University of Eastern Finland - Institute of Clinical Medicine
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.2139/ssrn.4421467
open_access.oa_status	green
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Progressive Myoclonic Epilepsy Type 1 (EPM1) Patients Present with Abnormal 1H MRS Brain Metabolic Profiles Associated with Cognitive Function
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T12604
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9976000189781189
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2745
primary_topic.subfield.display_name	Rheumatology
primary_topic.display_name	Glycogen Storage Diseases and Myoclonus
related_works	https://openalex.org/W2395519994, https://openalex.org/W2400363811, https://openalex.org/W2329266558, https://openalex.org/W1972267971, https://openalex.org/W2409973585, https://openalex.org/W2463700689, https://openalex.org/W2997997155, https://openalex.org/W2160387275, https://openalex.org/W1950201440, https://openalex.org/W1968490127
cited_by_count	1
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	1
locations_count	1
best_oa_location.id	doi:10.2139/ssrn.4421467
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4210172589
best_oa_location.source.issn	1556-5068
best_oa_location.source.type	repository
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	1556-5068
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	SSRN Electronic Journal
best_oa_location.source.host_organization	https://openalex.org/I1318003438
best_oa_location.source.host_organization_name	RELX Group (Netherlands)
best_oa_location.source.host_organization_lineage	https://openalex.org/I1318003438
best_oa_location.license
best_oa_location.pdf_url
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.2139/ssrn.4421467
primary_location.id	doi:10.2139/ssrn.4421467
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4210172589
primary_location.source.issn	1556-5068
primary_location.source.type	repository
primary_location.source.is_oa	True
primary_location.source.issn_l	1556-5068
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	SSRN Electronic Journal
primary_location.source.host_organization	https://openalex.org/I1318003438
primary_location.source.host_organization_name	RELX Group (Netherlands)
primary_location.source.host_organization_lineage	https://openalex.org/I1318003438
primary_location.license
primary_location.pdf_url
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.2139/ssrn.4421467
publication_date	2023-01-01
publication_year	2023
referenced_works_count	0
abstract_inverted_index
cited_by_percentile_year.max	95
cited_by_percentile_year.min	91
countries_distinct_count	1
institutions_distinct_count	9
citation_normalized_percentile.value	0.57997718
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False