Prolonged recombinant pregnancy hormone use in BRCA1 and BRCA2 mutation carriers Article Swipe
Herman Depypere
,
Yanrong Su
,
Nhi M. Dang
,
Bruce Poppe
,
Frank Z. Stanczyk
,
Jaak Janssens
,
José Russo
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1097/cej.0000000000000664
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1097/cej.0000000000000664
Background An early first full-time pregnancy substantially reduces the risk of developing breast cancer later in life. Extensive studies indicate that this protective effect is mediated by the pregnancy hormone human chorionic gonadotrophin (hCG). Methods In this proof-of-concept study 33 women with a BRCA mutation received recombinant-hCG (r-hCG). A 4-mm breast biopsy was obtained before (T1) and after 12 weeks of r-hCG injections (T2), as well as 6 months later (T3). The tissue was examined using RNA-sequencing methodology to determine if the ‘high-risk’ transcriptomic signature was converted to a ‘low-risk’ signature as in an early first full-time pregnancy. A stringent clinical safety monitoring was performed. Results The r-hCG administration was well tolerated in all participants. No clinically relevant changes were observed. In 25 women, the RNA quality was good for RNA sequencing in all three breast tissue biopsies. In response to the r-hCG, we observed 1907 differentially expressed genes (DEGs) (1032 up, 875 down) at T2 vs. T1 and 1065 DEGs (897 up, 168 down) at T3 vs. T1 in the group of women ( n = 11) not using any hormonal contraceptives during the study. There was no response at T2 vs. T1 and a small number of DEGs, 260 (214 up, 46 down) at T3 vs. T1 in the group of 14 women using contraceptives. Conclusions In summary, r-hCG has a remarkable effect on the gene expression profile of breast tissues from BRCA1/2 carriers who did not use any contraception. This opens an opportunity for a novel preventive strategy to reduce the incidence of breast cancer.
Related Topics
Concepts
Breast cancer
Medicine
Pregnancy
Human chorionic gonadotropin
BRCA mutation
Hormone
Transcriptome
Gynecology
Biopsy
Oncology
Andrology
Internal medicine
Gene
Cancer
Gene expression
Biology
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/cej.0000000000000664
- OA Status
- hybrid
- Cited By
- 4
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3134056623
All OpenAlex metadata
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https://openalex.org/W3134056623Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/cej.0000000000000664Digital Object Identifier
- Title
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Prolonged recombinant pregnancy hormone use in BRCA1 and BRCA2 mutation carriersWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-02-27Full publication date if available
- Authors
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Herman Depypere, Yanrong Su, Nhi M. Dang, Bruce Poppe, Frank Z. Stanczyk, Jaak Janssens, José RussoList of authors in order
- Landing page
-
https://doi.org/10.1097/cej.0000000000000664Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1097/cej.0000000000000664Direct OA link when available
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Breast cancer, Medicine, Pregnancy, Human chorionic gonadotropin, BRCA mutation, Hormone, Transcriptome, Gynecology, Biopsy, Oncology, Andrology, Internal medicine, Gene, Cancer, Gene expression, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 2, 2023: 1, 2022: 1Per-year citation counts (last 5 years)
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29Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.methodology | 77 |
| abstract_inverted_index.opportunity | 245 |
| abstract_inverted_index.gonadotrophin | 32 |
| abstract_inverted_index.participants. | 114 |
| abstract_inverted_index.substantially | 6 |
| abstract_inverted_index.RNA-sequencing | 76 |
| abstract_inverted_index.administration | 108 |
| abstract_inverted_index.contraception. | 241 |
| abstract_inverted_index.contraceptives | 182 |
| abstract_inverted_index.differentially | 146 |
| abstract_inverted_index.transcriptomic | 83 |
| abstract_inverted_index.‘low-risk’ | 89 |
| abstract_inverted_index.contraceptives. | 216 |
| abstract_inverted_index.recombinant-hCG | 46 |
| abstract_inverted_index.‘high-risk’ | 82 |
| abstract_inverted_index.proof-of-concept | 37 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5107386405 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I188703185, https://openalex.org/I2801227569 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8899999856948853 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.70939356 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |