Prolonged-release fampridine in multiple sclerosis: Improved ambulation effected by changes in walking pattern Article Swipe
Björn Zörner
,
Linard Filli
,
Katja Reuter
,
Sandra Kapitza
,
Lilla Lőrincz
,
Tabea Sutter
,
David Weller
,
Melinda Farkas
,
Chris Awai Easthope
,
Adam Czapliński
,
Michael Weller
,
Michael Linnebank
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1177/1352458515622695
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1177/1352458515622695
Background: Prolonged-release fampridine (PR-fampridine, 4-aminopyridine) increases walking speed in the timed 25-foot walk test (T25FW) in some patients (timed-walk responders) with multiple sclerosis (MS). Objective: To explore the effects of PR-fampridine on different aspects of walking function and to identify associated gait modifications in subjects with MS. Methods: In this prospective, randomized, placebo-controlled, double-blind, phase II study (FAMPKIN; clinicaltrials.gov , NCT01576354), subjects received a 6-week course of oral placebo or PR-fampridine treatment (10 mg, twice daily) before crossing over. Using 3D-motion-analysis, kinematic and kinetic parameters were assessed during treadmill walking (primary endpoint). Clinical outcome measures included T25FW, 6-minute walk test (6MWT), and balance scales. Physical activity in everyday life was measured with an accelerometer device. Results: Data from 55 patients were suitable for analysis. Seventeen subjects were timed-walk responders under PR-fampridine. For the total study population and for responders, a significant increase in walking speed (T25FW) and distance (6MWT) was observed. Gait pattern changes were found at the single-subject level and correlated with improvements in the T25FW and 6MWT. Physical activity was increased in responders. Conclusion: PR-fampridine improves walking speed, endurance, and everyday physical activity in a subset of subjects with MS and leads to individual modifications of the gait pattern.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/1352458515622695
- OA Status
- green
- Cited By
- 47
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2339597857
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2339597857Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1177/1352458515622695Digital Object Identifier
- Title
-
Prolonged-release fampridine in multiple sclerosis: Improved ambulation effected by changes in walking patternWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-01-14Full publication date if available
- Authors
-
Björn Zörner, Linard Filli, Katja Reuter, Sandra Kapitza, Lilla Lőrincz, Tabea Sutter, David Weller, Melinda Farkas, Chris Awai Easthope, Adam Czapliński, Michael Weller, Michael LinnebankList of authors in order
- Landing page
-
https://doi.org/10.1177/1352458515622695Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- Concepts
-
Gait, Preferred walking speed, Physical medicine and rehabilitation, Placebo, Treadmill, Multiple sclerosis, Physical therapy, Psychology, Medicine, Balance (ability), Activity monitor, Gait analysis, Physical activity, Alternative medicine, Pathology, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
47Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2023: 1, 2022: 7, 2021: 6, 2020: 7Per-year citation counts (last 5 years)
- References (count)
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30Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.balance | 102 |
| abstract_inverted_index.changes | 153 |
| abstract_inverted_index.device. | 114 |
| abstract_inverted_index.effects | 28 |
| abstract_inverted_index.explore | 26 |
| abstract_inverted_index.kinetic | 83 |
| abstract_inverted_index.outcome | 93 |
| abstract_inverted_index.pattern | 152 |
| abstract_inverted_index.placebo | 68 |
| abstract_inverted_index.scales. | 103 |
| abstract_inverted_index.walking | 6, 35, 89, 143, 178 |
| abstract_inverted_index.(primary | 90 |
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| abstract_inverted_index.Clinical | 92 |
| abstract_inverted_index.Methods: | 47 |
| abstract_inverted_index.Physical | 104, 169 |
| abstract_inverted_index.Results: | 115 |
| abstract_inverted_index.activity | 105, 170, 184 |
| abstract_inverted_index.assessed | 86 |
| abstract_inverted_index.crossing | 77 |
| abstract_inverted_index.distance | 147 |
| abstract_inverted_index.everyday | 107, 182 |
| abstract_inverted_index.function | 36 |
| abstract_inverted_index.identify | 39 |
| abstract_inverted_index.improves | 177 |
| abstract_inverted_index.included | 95 |
| abstract_inverted_index.increase | 141 |
| abstract_inverted_index.measured | 110 |
| abstract_inverted_index.measures | 94 |
| abstract_inverted_index.multiple | 21 |
| abstract_inverted_index.patients | 17, 119 |
| abstract_inverted_index.pattern. | 200 |
| abstract_inverted_index.physical | 183 |
| abstract_inverted_index.received | 62 |
| abstract_inverted_index.subjects | 44, 61, 125, 189 |
| abstract_inverted_index.suitable | 121 |
| abstract_inverted_index.(FAMPKIN; | 57 |
| abstract_inverted_index.Seventeen | 124 |
| abstract_inverted_index.analysis. | 123 |
| abstract_inverted_index.different | 32 |
| abstract_inverted_index.increased | 172 |
| abstract_inverted_index.increases | 5 |
| abstract_inverted_index.kinematic | 81 |
| abstract_inverted_index.observed. | 150 |
| abstract_inverted_index.sclerosis | 22 |
| abstract_inverted_index.treadmill | 88 |
| abstract_inverted_index.treatment | 71 |
| abstract_inverted_index.Objective: | 24 |
| abstract_inverted_index.associated | 40 |
| abstract_inverted_index.correlated | 161 |
| abstract_inverted_index.endpoint). | 91 |
| abstract_inverted_index.endurance, | 180 |
| abstract_inverted_index.fampridine | 2 |
| abstract_inverted_index.individual | 195 |
| abstract_inverted_index.parameters | 84 |
| abstract_inverted_index.population | 135 |
| abstract_inverted_index.responders | 128 |
| abstract_inverted_index.timed-walk | 127 |
| abstract_inverted_index.(timed-walk | 18 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.Conclusion: | 175 |
| abstract_inverted_index.randomized, | 51 |
| abstract_inverted_index.responders) | 19 |
| abstract_inverted_index.responders, | 138 |
| abstract_inverted_index.responders. | 174 |
| abstract_inverted_index.significant | 140 |
| abstract_inverted_index.improvements | 163 |
| abstract_inverted_index.prospective, | 50 |
| abstract_inverted_index.NCT01576354), | 60 |
| abstract_inverted_index.PR-fampridine | 30, 70, 176 |
| abstract_inverted_index.accelerometer | 113 |
| abstract_inverted_index.double-blind, | 53 |
| abstract_inverted_index.modifications | 42, 196 |
| abstract_inverted_index.PR-fampridine. | 130 |
| abstract_inverted_index.single-subject | 158 |
| abstract_inverted_index.(PR-fampridine, | 3 |
| abstract_inverted_index.4-aminopyridine) | 4 |
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| abstract_inverted_index.3D-motion-analysis, | 80 |
| abstract_inverted_index.placebo-controlled, | 52 |
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| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5028871525 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I4210100468 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6200000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.96201597 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |