Prone Positioning and Molecular Biomarkers in COVID and Non-COVID ARDS: A Narrative Review Article Swipe
Savino Spadaro
,
Jose Daniel Jimenez-Santana
,
Riccardo La Rosa
,
Giorgia Spinazzola
,
Pilar Argente Navarro
,
Carlo Alberto Volta
,
Gaetano Scaramuzzo
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/jcm13020317
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/jcm13020317
Prone positioning (PP) represents a therapeutic intervention with the proven capacity of ameliorating gas exchanges and ventilatory mechanics indicated in acute respiratory distress syndrome (ARDS). When PP is selectively applied to moderate-severe cases of ARDS, it sensitively affects clinical outcomes, including mortality. After the COVID-19 outbreak, clinical application of PP peaked worldwide and was applied in 60% of treated cases, according to large reports. Research on this topic has revealed many physiological underpinnings of PP, focusing on regional ventilation redistribution and the reduction of parenchymal stress and strain. However, there is a lack of evidence on biomarkers behavior in different phases and phenotypes of ARDS. Patients response to PP are, to date, decided on PaO2/FiO2 ratio improvement, whereas scarce data exist on biomarker tracking during PP. The purpose of this review is to explore current evidence on the clinical relevance of biomarkers in the setting of moderate-severe ARDS of different etiologies (i.e., COVID and non-COVID-related ARDS). Moreover, this review focuses on how PP may modulate biomarkers and which biomarkers may have a role in outcome prediction in ARDS patients.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm13020317
- https://www.mdpi.com/2077-0383/13/2/317/pdf?version=1704463811
- OA Status
- gold
- Cited By
- 3
- References
- 111
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390617981
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390617981Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm13020317Digital Object Identifier
- Title
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Prone Positioning and Molecular Biomarkers in COVID and Non-COVID ARDS: A Narrative ReviewWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-05Full publication date if available
- Authors
-
Savino Spadaro, Jose Daniel Jimenez-Santana, Riccardo La Rosa, Giorgia Spinazzola, Pilar Argente Navarro, Carlo Alberto Volta, Gaetano ScaramuzzoList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm13020317Publisher landing page
- PDF URL
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https://www.mdpi.com/2077-0383/13/2/317/pdf?version=1704463811Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2077-0383/13/2/317/pdf?version=1704463811Direct OA link when available
- Concepts
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ARDS, Medicine, Coronavirus disease 2019 (COVID-19), Intensive care medicine, Biomarker, Acute respiratory distress, Prone position, Clinical significance, Mechanical ventilation, Internal medicine, Lung, Surgery, Disease, Infectious disease (medical specialty), Genetics, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3Per-year citation counts (last 5 years)
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111Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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