Prooxidation and Cytotoxicity of Selenium Nanoparticles at Nonlethal Level in Sprague-Dawley Rats and Buffalo Rat Liver Cells Article Swipe
Haidong Wang
,
Yudan He
,
Lujie Liu
,
Wenjing Tao
,
Geng Wang
,
Wanjing Sun
,
Xun Pei
,
Zhiping Xiao
,
Yuyue Jin
,
Minqi Wang
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1155/2020/7680276
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1155/2020/7680276
The effects of selenium nanoparticles (SeNPs) on the antioxidant capacity in Sprague-Dawley (SD) rats were investigated. The rats were given intragastric administration of an SeNP suspension at doses of 0, 2, 4, and 8 mg Se/kg BW for two weeks. The antioxidant capacity in serum and organic tissues (liver, heart, and kidney) and the gene expression levels of glutathione peroxidase 1 (GPX1) and glutathione peroxidase 4 (GPX4) in the liver were measured. Buffalo rat liver (BRL) cell lines were further constructed to explore the cytotoxicity mechanism induced by SeNPs through the determination of antioxidant capacity; cell activity; apoptosis; and Caspase-3, Caspase-8, and Caspase-9 family activities. The results showed that SeNP administration over 4.0 mg Se/kg BW decreased the antioxidant capacities in the serum, liver, and heart and downregulated mRNA expression of GPX1 and GPX4 in the liver. The BRL cell line experiments showed that treatment with over 24 μ M SeNPs decreased the viability of the cells and damaged the antioxidant capacity. Flow cytometry analysis showed that decreased cell viability induced by SeNPs is mainly due to apoptosis, rather than cell necrosis. Caspase-3 and Caspase-8 activities were also increased when BRL cells were treated with 24 μ M and 48 μ M SeNPs. Taken together, a nonlethal level of SeNPs could impair the antioxidant capacity in serum and organic tissues of rats, and the liver is the most sensitive to the toxicity of SeNPs. A pharmacological dose of SeNPs could lead to cytotoxicity and induce cell death through apoptosis and extrinsic pathways contributing to SeNP-induced apoptosis in BRL cells.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2020/7680276
- https://downloads.hindawi.com/journals/omcl/2020/7680276.pdf
- OA Status
- hybrid
- Cited By
- 30
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3068802665
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3068802665Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1155/2020/7680276Digital Object Identifier
- Title
-
Prooxidation and Cytotoxicity of Selenium Nanoparticles at Nonlethal Level in Sprague-Dawley Rats and Buffalo Rat Liver CellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-08-19Full publication date if available
- Authors
-
Haidong Wang, Yudan He, Lujie Liu, Wenjing Tao, Geng Wang, Wanjing Sun, Xun Pei, Zhiping Xiao, Yuyue Jin, Minqi WangList of authors in order
- Landing page
-
https://doi.org/10.1155/2020/7680276Publisher landing page
- PDF URL
-
https://downloads.hindawi.com/journals/omcl/2020/7680276.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://downloads.hindawi.com/journals/omcl/2020/7680276.pdfDirect OA link when available
- Concepts
-
GPX1, Apoptosis, Cytotoxicity, Antioxidant, Viability assay, Glutathione, Glutathione peroxidase, GPX4, Liver cell, Toxicity, Programmed cell death, Pharmacology, Chemistry, Biology, Molecular biology, Internal medicine, Biochemistry, Medicine, Enzyme, Superoxide dismutase, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 4, 2023: 7, 2022: 6, 2021: 7Per-year citation counts (last 5 years)
- References (count)
-
53Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Oxidative Medicine and Cellular Longevity |
| primary_location.landing_page_url | https://doi.org/10.1155/2020/7680276 |
| publication_date | 2020-08-19 |
| publication_year | 2020 |
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