Prophylactic and therapeutic use of synthetically glycosylated antigens to limit allergic airway disease Article Swipe
Jorge Emiliano Gomez Medellin
,
Trevor Ung
,
Trevin Kurtanich
,
Joseph W. Reda
,
Thomas J. Wang
,
Kevin Chang
,
Shijie Cao
,
Melody A. Swartz
,
Jeffrey A. Hubbell
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.4049/jimmunol.210.supp.67.23
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.4049/jimmunol.210.supp.67.23
Asthma is a disease involving chronic airway inflammation affecting more than 300 million people worldwide. There is currently no cure for asthma. While effective, corticosteroids cause broad immune suppression and long-term debilitating disease. Novel immune modulatory therapeutics leave patients vulnerable to infections. Therefore, there is a current need for new therapeutics that target the underlying causes of the disease without triggering detrimental side effects. Through synthetic glycosylation, our platform targets hepatic antigen presenting cells and leverages the liver’s tolerance-inducing mechanisms to limit inflammatory T cell responses, while promoting regulatory T cell (Treg) responses, thus preventing broad immunosuppression. In a model of experimental allergic airway inflammation, prophylactic treatment with synthetically mannosylated OVA (pManOVA) ameliorated the allergic response to inhaled OVA. Our treatment reduced lung and airway eosinophilia, systemic levels of IgE and OVA-specific IgG1, and airway mucus. Furthermore, pManOVA treatment reduced OVA specific lung TH2 cells, and exhibited reduced production of IL-4, IL-5 and IL-13 upon antigen specific restimulation. Treatment with pManOVA was accompanied by induction of OVA-specific Tregs, which negatively correlated with features of allergic airway disease. In previously sensitized mice, therapeutic intervention with pManOVA reduced airway and lung eosinophilia, B cell and CD4+ T cell inflammation. Altogether, these data suggest a potential role for prophylactic and therapeutic intervention with synthetically glycosylated allergens in ameliorating disease severity in a model of allergic airway inflammation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4049/jimmunol.210.supp.67.23
- https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/67.23/1634044/67_23.pdf
- OA Status
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- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4385685393Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4049/jimmunol.210.supp.67.23Digital Object Identifier
- Title
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Prophylactic and therapeutic use of synthetically glycosylated antigens to limit allergic airway diseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-05-01Full publication date if available
- Authors
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Jorge Emiliano Gomez Medellin, Trevor Ung, Trevin Kurtanich, Joseph W. Reda, Thomas J. Wang, Kevin Chang, Shijie Cao, Melody A. Swartz, Jeffrey A. HubbellList of authors in order
- Landing page
-
https://doi.org/10.4049/jimmunol.210.supp.67.23Publisher landing page
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https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/67.23/1634044/67_23.pdfDirect link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/67.23/1634044/67_23.pdfDirect OA link when available
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Immunology, Medicine, Immune system, Eosinophilia, Immunoglobulin E, Inflammation, Antigen, Allergy, Asthma, Airway, Antibody, SurgeryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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