Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection Article Swipe
Katherine V. Houser
,
Lisa Gretebeck
,
Tianlei Ying
,
Yanping Wang
,
Leatrice Vogel
,
Elaine W. Lamirande
,
Kevin W. Bock
,
Ian N. Moore
,
Dimiter S. Dimitrov
,
Kanta Subbarao
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1093/infdis/jiw080
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1093/infdis/jiw080
With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40-9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.
Related Topics
Concepts
Middle East respiratory syndrome coronavirus
Virology
Middle East respiratory syndrome
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Monoclonal antibody
Coronavirus disease 2019 (COVID-19)
Coronavirus
Coronavirus Infections
2019-20 coronavirus outbreak
Betacoronavirus
Medicine
Antibody
Immunology
Biology
Outbreak
Pathology
Infectious disease (medical specialty)
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/infdis/jiw080
- https://academic.oup.com/jid/article-pdf/213/10/1557/17410481/jiw080.pdf
- OA Status
- bronze
- Cited By
- 97
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2341097180
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2341097180Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/infdis/jiw080Digital Object Identifier
- Title
-
Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV InfectionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-03-03Full publication date if available
- Authors
-
Katherine V. Houser, Lisa Gretebeck, Tianlei Ying, Yanping Wang, Leatrice Vogel, Elaine W. Lamirande, Kevin W. Bock, Ian N. Moore, Dimiter S. Dimitrov, Kanta SubbaraoList of authors in order
- Landing page
-
https://doi.org/10.1093/infdis/jiw080Publisher landing page
- PDF URL
-
https://academic.oup.com/jid/article-pdf/213/10/1557/17410481/jiw080.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/jid/article-pdf/213/10/1557/17410481/jiw080.pdfDirect OA link when available
- Concepts
-
Middle East respiratory syndrome coronavirus, Virology, Middle East respiratory syndrome, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Monoclonal antibody, Coronavirus disease 2019 (COVID-19), Coronavirus, Coronavirus Infections, 2019-20 coronavirus outbreak, Betacoronavirus, Medicine, Antibody, Immunology, Biology, Outbreak, Pathology, Infectious disease (medical specialty), DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
97Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 4, 2023: 6, 2022: 7, 2021: 17Per-year citation counts (last 5 years)
- References (count)
-
15Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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