PROSTACYCLIN-ANALOG THERAPY FOR PULMONARY VASCULAR DYSFUNCTION DURING SEVERE ACUTE CHEST SYNDROME IN SICKLE CELL DISEASE Article Swipe
Julien Lopinto
,
Elsa Moncomble
,
Ségolène Gendreau
,
Guillaume Carteaux
,
François Bagate
,
Nicolas de Prost
,
Pablo Bartolucci
,
Anoosha Habibi
,
Keyvan Razazi
,
Armand Mekontso Dessap
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1097/shk.0000000000002593
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1097/shk.0000000000002593
Background: The purpose of this study is to evaluate the impact of parenteral epoprostenol in sickle cell adults patients presenting acute cor pulmonale (ACP) complicating severe acute chest syndrome (ACS). Methods: Retrospective single-center analysis of sickle cell patients in ICU with ACP complicating severe ACS receiving epoprostenol, in addition to usual care (prostacyclin group) or usual care alone (control group). Primary outcome: relative change in pulmonary artery systolic pressure over 1 day. Results: 45 patients were included in the study, including 21 who received usual care and 24 who received epoprostenol. There was a significant reduction in pulmonary artery systolic pressure (PASP) during the first 24 h in the prostacyclin group (from 69 [60–77] to 52 [42–61] mmHg, P < 0.001) but not in the control group (from 50 [40–56] to 50 [35–55] mmHg, P = 0.285). The median decrease in PASP was greater in the prostacyclin group than in the control group (−25% [−33;-13] vs. −2% [−8; 0], P < 0.001). Conclusion: Parenteral prostacyclin analog therapy is associated with a significant reduction in PASP in patients with SCD admitted in ICU with ACS-related ACP.
Related Topics
Concepts
Medicine
Prostacyclin
Acute chest syndrome
Pulmonary hypertension
Internal medicine
Pulmonary artery
Cardiology
Sickle cell anemia
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/shk.0000000000002593
- OA Status
- hybrid
- References
- 43
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409719492Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/shk.0000000000002593Digital Object Identifier
- Title
-
PROSTACYCLIN-ANALOG THERAPY FOR PULMONARY VASCULAR DYSFUNCTION DURING SEVERE ACUTE CHEST SYNDROME IN SICKLE CELL DISEASEWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-23Full publication date if available
- Authors
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Julien Lopinto, Elsa Moncomble, Ségolène Gendreau, Guillaume Carteaux, François Bagate, Nicolas de Prost, Pablo Bartolucci, Anoosha Habibi, Keyvan Razazi, Armand Mekontso DessapList of authors in order
- Landing page
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https://doi.org/10.1097/shk.0000000000002593Publisher landing page
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1097/shk.0000000000002593Direct OA link when available
- Concepts
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Medicine, Prostacyclin, Acute chest syndrome, Pulmonary hypertension, Internal medicine, Pulmonary artery, Cardiology, Sickle cell anemia, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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