Prostatic Urethral Lift (PUL) for obstructive median lobes: 12 month results of the MedLift Study Article Swipe
YOU?
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· 2018
· Open Access
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· DOI: https://doi.org/10.1038/s41391-018-0118-x
Evidence indicating Prostatic Urethral Lift (PUL) delivers significant improvement in symptomatic BPH with low morbidity is based on subjects with lateral lobe (LL) enlargement only. MedLift was an FDA IDE extension of the L.I.F.T. randomized study designed to examine safety and efficacy of PUL for treatment of obstructive middle lobes (OML). Inclusion criteria for this non-randomized cohort were identical to the L.I.F.T. randomized study, except for requiring an OML: ≥ 50 years of age, IPSS ≥ 13, and Qmax ≤ 12 ml/s. Primary endpoint analysis quantified improvement in IPSS over baseline and rate of post-procedure serious complications. Quantification of symptom relief, quality of life, flow rate, and sexual function occurred through 12 months. Outcomes were compared to historical L.I.F.T LL results and were combined to demonstrate the full effectiveness of PUL. Of the 71 screened subjects, 45 were enrolled. At 1, 3, 6, and 12 months, mean IPSS improved from baseline at least 13.5 points (p < 0.0001). Quality of life and BPHII were similarly improved (>60% and >70%, respectively at 3, 6, and 12 months, p < 0.0001). Mean Qmax improvement ranged from 90 to 129% (p < 0.0001). At 1 month, 86% (CI 73-94%) reported ≥70 on the Quality of Recovery scale, 80% (CI 66-89%) reported being "much" or "very much better," and 89% (CI 76-95%) would recommend the procedure. Compared to LL subjects, OML subjects' symptoms improved at least as much at every time point (OML range 13.5-15.9, LL range 9.9-11.1, p ≤ 0.01). On combining OML with LL data, >70% (range CI 63-81%) of subjects demonstrated ≥ 8 point improvement in IPSS through 12 months. Analysis of the combined dataset indicates ≥ 40% (CI 30-51%) of sexually active men improved the minimal clinically important difference in erectile function through 12 months. Prostates, including those with middle lobe obstruction, can be treated with the PUL procedure safely and effectively.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41391-018-0118-x
- https://www.nature.com/articles/s41391-018-0118-x.pdf
- OA Status
- hybrid
- Cited By
- 95
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2904247792
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2904247792Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41391-018-0118-xDigital Object Identifier
- Title
-
Prostatic Urethral Lift (PUL) for obstructive median lobes: 12 month results of the MedLift StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-12-12Full publication date if available
- Authors
-
Daniel B. Rukstalis, Douglas Grier, Sean P. Stroup, Ronald Tutrone, Euclid DeSouza, Sheldon Freedman, Richard David, Jed Kamientsky, Gregg EureList of authors in order
- Landing page
-
https://doi.org/10.1038/s41391-018-0118-xPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s41391-018-0118-x.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41391-018-0118-x.pdfDirect OA link when available
- Concepts
-
Medicine, Urology, Clinical endpoint, Quality of life (healthcare), Randomized controlled trial, Cohort, Erectile dysfunction, Surgery, Internal medicine, NursingTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
95Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 14, 2023: 14, 2022: 11, 2021: 26Per-year citation counts (last 5 years)
- References (count)
-
26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.non-randomized | 55 |
| abstract_inverted_index.post-procedure | 94 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5110832638 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I4210088597, https://openalex.org/I4210131001 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/5 |
| sustainable_development_goals[0].score | 0.5600000023841858 |
| sustainable_development_goals[0].display_name | Gender equality |
| citation_normalized_percentile.value | 0.99013266 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |