Proteasome inhibitor associated thrombotic microangiopathy Article Swipe
Jennifer C. Yui
,
Jan Van Keer
,
Brendan M. Weiss
,
Adam Waxman
,
Matthew B. Palmer
,
Vivette D. D’Agati
,
Efstathios Kastritis
,
Meletios Α. Dimopoulos
,
Ravi Vij
,
Dhruv Bansal
,
David Dingli
,
Samih H. Nasr
,
Nelson Leung
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1002/ajh.24447
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1002/ajh.24447
A variety of medications have been implicated in the causation of thrombotic microangiopathy (TMA). Recently, a few case reports have emerged of TMA attributed to the proteasome inhibitors (PI) bortezomib and carfilzomib in patients with multiple myeloma. The aim of this case series was to better characterize the role of PI in the etiology of drug‐induced TMA. We describe eleven patients from six medical centers from around the world who developed TMA while being treated with PI. The median time between medication initiation and diagnosis of TMA was 21 days (range 5 days to 17 months). Median laboratory values at diagnosis included hemoglobin—7.5 g dL −1 , platelet count—20 × 10 9 /L, LDH—698 U L −1 , creatinine—3.12 mg dL −1 . No patient had any other cause of TMA, including ADAMTS13 inhibition, other malignancy or use of any other medication previously associated with TMA. Nine patients had resolution of TMA without evidence of hemolysis after withdrawal of PI. Two patients had stabilization of laboratory values but persistent evidence of hemolysis despite medication withdrawal. One patient had recurrence of TMA with rechallenge of PI. There is a strong level of evidence that PI can cause DITMA. In evaluating patients with suspected TMA, PI use should be recognized as a potential etiology, and these medications should be discontinued promptly if thought to be the cause of TMA. Am. J. Hematol. 91:E348–E352, 2016. © 2016 Wiley Periodicals, Inc.
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- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1002/ajh.24447
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.24447
- OA Status
- bronze
- Cited By
- 112
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2416137380
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- OpenAlex ID
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https://openalex.org/W2416137380Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/ajh.24447Digital Object Identifier
- Title
-
Proteasome inhibitor associated thrombotic microangiopathyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-06-11Full publication date if available
- Authors
-
Jennifer C. Yui, Jan Van Keer, Brendan M. Weiss, Adam Waxman, Matthew B. Palmer, Vivette D. D’Agati, Efstathios Kastritis, Meletios Α. Dimopoulos, Ravi Vij, Dhruv Bansal, David Dingli, Samih H. Nasr, Nelson LeungList of authors in order
- Landing page
-
https://doi.org/10.1002/ajh.24447Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.24447Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajh.24447Direct OA link when available
- Concepts
-
Thrombotic microangiopathy, Medicine, Etiology, Internal medicine, ADAMTS13, Gastroenterology, Multiple myeloma, Bortezomib, Creatinine, Hemolysis, Malignancy, Platelet, Thrombotic thrombocytopenic purpura, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
112Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 11, 2023: 7, 2022: 17, 2021: 19Per-year citation counts (last 5 years)
- References (count)
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26Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.suspected | 201 |
| abstract_inverted_index.associated | 143 |
| abstract_inverted_index.attributed | 23 |
| abstract_inverted_index.bortezomib | 29 |
| abstract_inverted_index.count—20 | 108 |
| abstract_inverted_index.evaluating | 198 |
| abstract_inverted_index.implicated | 6 |
| abstract_inverted_index.inhibitors | 27 |
| abstract_inverted_index.initiation | 82 |
| abstract_inverted_index.laboratory | 97, 165 |
| abstract_inverted_index.malignancy | 135 |
| abstract_inverted_index.medication | 81, 141, 173 |
| abstract_inverted_index.persistent | 168 |
| abstract_inverted_index.previously | 142 |
| abstract_inverted_index.proteasome | 26 |
| abstract_inverted_index.recognized | 207 |
| abstract_inverted_index.recurrence | 178 |
| abstract_inverted_index.resolution | 149 |
| abstract_inverted_index.thrombotic | 11 |
| abstract_inverted_index.withdrawal | 157 |
| abstract_inverted_index.carfilzomib | 31 |
| abstract_inverted_index.inhibition, | 133 |
| abstract_inverted_index.medications | 3, 214 |
| abstract_inverted_index.rechallenge | 182 |
| abstract_inverted_index.withdrawal. | 174 |
| abstract_inverted_index.Periodicals, | 235 |
| abstract_inverted_index.characterize | 46 |
| abstract_inverted_index.discontinued | 217 |
| abstract_inverted_index.stabilization | 163 |
| abstract_inverted_index.drug‐induced | 55 |
| abstract_inverted_index.91:E348–E352, | 230 |
| abstract_inverted_index.microangiopathy | 12 |
| abstract_inverted_index.hemoglobin—7.5 | 102 |
| abstract_inverted_index.creatinine—3.12 | 118 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5082304508 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I1330342723 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8500000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.96133431 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |