Protein-Bound Nano-Injectable Suspension: Unveiling the Promises and Challenges Article Swipe
YOU?
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· 2025
· Open Access
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· DOI: https://doi.org/10.3390/applnano6020009
Protein-bound nano-injectable solutions represent a cutting-edge advancement in nanomedicine, offering a versatile platform for precise and controlled drug delivery. By leveraging the biocompatibility and functional versatility of proteins such as albumin, gelatin, and casein, these nano systems enhance drug solubility, prolong circulation time, and improve site-specific targeting, which are particularly beneficial in cancer and inflammatory diseases. This review provides a comprehensive overview of their formulation strategies, physicochemical characteristics, and biological behavior. Emphasis is placed on therapeutic applications, regulatory considerations, fabrication techniques, and the underlying mechanisms of drug–protein interactions. This review also highlights improved pharmacokinetics and reduced systemic toxicity, while also critically addressing challenges like immunogenicity, protein instability, and production scalability. Recent FDA-approved formulations and emerging innovations in precision medicine and theranostics underscore the transformative potential of protein-based nanosuspensions in next-generation drug delivery systems.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/applnano6020009
- https://www.mdpi.com/2673-3501/6/2/9/pdf?version=1748611430
- OA Status
- gold
- Cited By
- 5
- References
- 109
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411001074
Raw OpenAlex JSON
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https://openalex.org/W4411001074Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/applnano6020009Digital Object Identifier
- Title
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Protein-Bound Nano-Injectable Suspension: Unveiling the Promises and ChallengesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-05-30Full publication date if available
- Authors
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Eknath D. Ahire, Namrata Savaliya, Kalarav V. Makwana, Sagar Salave, Mandeep Kaur Banth, Bhavesh Bhavsar, Dignesh Khunt, Bhupendra G. PrajapatiList of authors in order
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https://doi.org/10.3390/applnano6020009Publisher landing page
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https://www.mdpi.com/2673-3501/6/2/9/pdf?version=1748611430Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2673-3501/6/2/9/pdf?version=1748611430Direct OA link when available
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Nano-, Suspension (topology), Nanotechnology, Chemistry, Materials science, Chemical engineering, Engineering, Mathematics, Pure mathematics, HomotopyTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 5Per-year citation counts (last 5 years)
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109Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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