Proteolytically Resistant Bioactive Peptide-Grafted Sr/Mg-Doped Hardystonite Foams: Comparison of Two Covalent Functionalization Strategies Article Swipe
Annj Zamuner
,
Elena Zeni
,
Hamada Elsayed
,
Michele Di Foggia
,
Paola Taddei
,
Antonella Pasquato
,
L. Di Silvio
,
Enrico Bernardo
,
Paola Brun
,
Monica Dettin
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/biomimetics8020185
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/biomimetics8020185
Hardystonite-based (HT) bioceramic foams were easily obtained via thermal treatment of silicone resins and reactive oxide fillers in air. By using a commercial silicone, incorporating strontium oxide and magnesium oxide precursors (as well as CaO and ZnO), and treating it at 1100 °C, a complex solid solution (Ca1.4Sr0.6Zn0.85Mg0.15Si2O7) that has superior biocompatibility and bioactivity properties compared to pure hardystonite (Ca2ZnSi2O7) can be obtained. Proteolytic-resistant adhesive peptide mapped on vitronectin (D2HVP), was selectively grafted to Sr/Mg-doped HT foams using two different strategies. Unfortunately, the first method (via protected peptide) was unsuitable for acid-sensitive materials such as Sr/Mg-doped HT, resulting in the release of cytotoxic levels of Zinc over time, with consequent negative cellular response. To overcome this unexpected result, a novel functionalization strategy requiring aqueous solution and mild conditions was designed. Sr/Mg-doped HT functionalized with this second strategy (via aldehyde peptide) showed a dramatic increase in human osteoblast proliferation at 6 days compared to only silanized or non-functionalized samples. Furthermore, we demonstrated that the functionalization treatment does not induce any cytotoxicity. Functionalized foams enhanced mRNA-specific transcript levels coding IBSP, VTN, RUNX2, and SPP1 at 2 days post-seeding. In conclusion, the second functionalization strategy proved to be appropriate for this specific biomaterial and was effective at enhancing the material’s bioactivity.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomimetics8020185
- https://www.mdpi.com/2313-7673/8/2/185/pdf?version=1683191974
- OA Status
- gold
- Cited By
- 2
- References
- 72
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4367623897
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4367623897Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/biomimetics8020185Digital Object Identifier
- Title
-
Proteolytically Resistant Bioactive Peptide-Grafted Sr/Mg-Doped Hardystonite Foams: Comparison of Two Covalent Functionalization StrategiesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-04-29Full publication date if available
- Authors
-
Annj Zamuner, Elena Zeni, Hamada Elsayed, Michele Di Foggia, Paola Taddei, Antonella Pasquato, L. Di Silvio, Enrico Bernardo, Paola Brun, Monica DettinList of authors in order
- Landing page
-
https://doi.org/10.3390/biomimetics8020185Publisher landing page
- PDF URL
-
https://www.mdpi.com/2313-7673/8/2/185/pdf?version=1683191974Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2313-7673/8/2/185/pdf?version=1683191974Direct OA link when available
- Concepts
-
Surface modification, Covalent bond, Peptide, Doping, Materials science, Chemical modification, Chemistry, Combinatorial chemistry, Chemical engineering, Polymer chemistry, Organic chemistry, Biochemistry, Optoelectronics, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
72Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4367623897 |
|---|---|
| doi | https://doi.org/10.3390/biomimetics8020185 |
| ids.doi | https://doi.org/10.3390/biomimetics8020185 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37218771 |
| ids.openalex | https://openalex.org/W4367623897 |
| fwci | 0.3177561 |
| type | article |
| title | Proteolytically Resistant Bioactive Peptide-Grafted Sr/Mg-Doped Hardystonite Foams: Comparison of Two Covalent Functionalization Strategies |
| biblio.issue | 2 |
| biblio.volume | 8 |
| biblio.last_page | 185 |
| biblio.first_page | 185 |
| topics[0].id | https://openalex.org/T10059 |
| topics[0].field.id | https://openalex.org/fields/22 |
| topics[0].field.display_name | Engineering |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/3 |
| topics[0].domain.display_name | Physical Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2204 |
| topics[0].subfield.display_name | Biomedical Engineering |
| topics[0].display_name | Bone Tissue Engineering Materials |
| topics[1].id | https://openalex.org/T12110 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.998199999332428 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2745 |
| topics[1].subfield.display_name | Rheumatology |
| topics[1].display_name | Bone and Dental Protein Studies |
| topics[2].id | https://openalex.org/T12071 |
| topics[2].field.id | https://openalex.org/fields/22 |
| topics[2].field.display_name | Engineering |
| topics[2].score | 0.9954000115394592 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2212 |
| topics[2].subfield.display_name | Ocean Engineering |
| topics[2].display_name | Marine Biology and Environmental Chemistry |
| is_xpac | False |
| apc_list.value | 1600 |
| apc_list.currency | CHF |
| apc_list.value_usd | 1732 |
| apc_paid.value | 1600 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 1732 |
| concepts[0].id | https://openalex.org/C115537861 |
| concepts[0].level | 2 |
| concepts[0].score | 0.8967029452323914 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q7645993 |
| concepts[0].display_name | Surface modification |
| concepts[1].id | https://openalex.org/C180577832 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7145206928253174 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q127920 |
| concepts[1].display_name | Covalent bond |
| concepts[2].id | https://openalex.org/C2779281246 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5616271495819092 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q172847 |
| concepts[2].display_name | Peptide |
| concepts[3].id | https://openalex.org/C57863236 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5110974907875061 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1130571 |
| concepts[3].display_name | Doping |
| concepts[4].id | https://openalex.org/C192562407 |
| concepts[4].level | 0 |
| concepts[4].score | 0.4278285503387451 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[4].display_name | Materials science |
| concepts[5].id | https://openalex.org/C184133267 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4193934202194214 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q5090480 |
| concepts[5].display_name | Chemical modification |
| concepts[6].id | https://openalex.org/C185592680 |
| concepts[6].level | 0 |
| concepts[6].score | 0.3830134868621826 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[6].display_name | Chemistry |
| concepts[7].id | https://openalex.org/C21951064 |
| concepts[7].level | 1 |
| concepts[7].score | 0.35819804668426514 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q899212 |
| concepts[7].display_name | Combinatorial chemistry |
| concepts[8].id | https://openalex.org/C42360764 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3419184684753418 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q83588 |
| concepts[8].display_name | Chemical engineering |
| concepts[9].id | https://openalex.org/C188027245 |
| concepts[9].level | 1 |
| concepts[9].score | 0.265491247177124 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q750446 |
| concepts[9].display_name | Polymer chemistry |
| concepts[10].id | https://openalex.org/C178790620 |
| concepts[10].level | 1 |
| concepts[10].score | 0.18254771828651428 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[10].display_name | Organic chemistry |
| concepts[11].id | https://openalex.org/C55493867 |
| concepts[11].level | 1 |
| concepts[11].score | 0.15399691462516785 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[11].display_name | Biochemistry |
| concepts[12].id | https://openalex.org/C49040817 |
| concepts[12].level | 1 |
| concepts[12].score | 0.08537164330482483 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q193091 |
| concepts[12].display_name | Optoelectronics |
| concepts[13].id | https://openalex.org/C127413603 |
| concepts[13].level | 0 |
| concepts[13].score | 0.06000235676765442 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q11023 |
| concepts[13].display_name | Engineering |
| keywords[0].id | https://openalex.org/keywords/surface-modification |
| keywords[0].score | 0.8967029452323914 |
| keywords[0].display_name | Surface modification |
| keywords[1].id | https://openalex.org/keywords/covalent-bond |
| keywords[1].score | 0.7145206928253174 |
| keywords[1].display_name | Covalent bond |
| keywords[2].id | https://openalex.org/keywords/peptide |
| keywords[2].score | 0.5616271495819092 |
| keywords[2].display_name | Peptide |
| keywords[3].id | https://openalex.org/keywords/doping |
| keywords[3].score | 0.5110974907875061 |
| keywords[3].display_name | Doping |
| keywords[4].id | https://openalex.org/keywords/materials-science |
| keywords[4].score | 0.4278285503387451 |
| keywords[4].display_name | Materials science |
| keywords[5].id | https://openalex.org/keywords/chemical-modification |
| keywords[5].score | 0.4193934202194214 |
| keywords[5].display_name | Chemical modification |
| keywords[6].id | https://openalex.org/keywords/chemistry |
| keywords[6].score | 0.3830134868621826 |
| keywords[6].display_name | Chemistry |
| keywords[7].id | https://openalex.org/keywords/combinatorial-chemistry |
| keywords[7].score | 0.35819804668426514 |
| keywords[7].display_name | Combinatorial chemistry |
| keywords[8].id | https://openalex.org/keywords/chemical-engineering |
| keywords[8].score | 0.3419184684753418 |
| keywords[8].display_name | Chemical engineering |
| keywords[9].id | https://openalex.org/keywords/polymer-chemistry |
| keywords[9].score | 0.265491247177124 |
| keywords[9].display_name | Polymer chemistry |
| keywords[10].id | https://openalex.org/keywords/organic-chemistry |
| keywords[10].score | 0.18254771828651428 |
| keywords[10].display_name | Organic chemistry |
| keywords[11].id | https://openalex.org/keywords/biochemistry |
| keywords[11].score | 0.15399691462516785 |
| keywords[11].display_name | Biochemistry |
| keywords[12].id | https://openalex.org/keywords/optoelectronics |
| keywords[12].score | 0.08537164330482483 |
| keywords[12].display_name | Optoelectronics |
| keywords[13].id | https://openalex.org/keywords/engineering |
| keywords[13].score | 0.06000235676765442 |
| keywords[13].display_name | Engineering |
| language | en |
| locations[0].id | doi:10.3390/biomimetics8020185 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210206423 |
| locations[0].source.issn | 2313-7673 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2313-7673 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Biomimetics |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2313-7673/8/2/185/pdf?version=1683191974 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Biomimetics |
| locations[0].landing_page_url | https://doi.org/10.3390/biomimetics8020185 |
| locations[1].id | pmid:37218771 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Biomimetics (Basel, Switzerland) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37218771 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10204510 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10204510/pdf/biomimetics-08-00185.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Biomimetics (Basel) |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10204510 |
| locations[3].id | pmh:oai:cris.unibo.it:11585/953144 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306402579 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) |
| locations[3].source.host_organization | https://openalex.org/I4210117483 |
| locations[3].source.host_organization_name | Istituto di Ematologia di Bologna |
| locations[3].source.host_organization_lineage | https://openalex.org/I4210117483 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | info:eu-repo/semantics/article |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://www.mdpi.com/2313-7673/8/2/185 |
| locations[4].id | pmh:oai:doaj.org/article:de73bb7d98ad46bba9b7263b800dcc6f |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Biomimetics, Vol 8, Iss 2, p 185 (2023) |
| locations[4].landing_page_url | https://doaj.org/article/de73bb7d98ad46bba9b7263b800dcc6f |
| locations[5].id | pmh:oai:mdpi.com:/2313-7673/8/2/185/ |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306400947 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | True |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | MDPI (MDPI AG) |
| locations[5].source.host_organization | https://openalex.org/I4210097602 |
| locations[5].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[5].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[5].license | cc-by |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | Text |
| locations[5].license_id | https://openalex.org/licenses/cc-by |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | Biomimetics; Volume 8; Issue 2; Pages: 185 |
| locations[5].landing_page_url | https://dx.doi.org/10.3390/biomimetics8020185 |
| locations[6].id | pmh:oai:www.research.unipd.it:11577/3488170 |
| locations[6].is_oa | True |
| locations[6].source.id | https://openalex.org/S4306402448 |
| locations[6].source.issn | |
| locations[6].source.type | repository |
| locations[6].source.is_oa | False |
| locations[6].source.issn_l | |
| locations[6].source.is_core | False |
| locations[6].source.is_in_doaj | False |
| locations[6].source.display_name | Padua Research Archive (University of Padua) |
| locations[6].source.host_organization | https://openalex.org/I138689650 |
| locations[6].source.host_organization_name | University of Padua |
| locations[6].source.host_organization_lineage | https://openalex.org/I138689650 |
| locations[6].license | cc-by |
| locations[6].pdf_url | |
| locations[6].version | submittedVersion |
| locations[6].raw_type | info:eu-repo/semantics/article |
| locations[6].license_id | https://openalex.org/licenses/cc-by |
| locations[6].is_accepted | False |
| locations[6].is_published | False |
| locations[6].raw_source_name | |
| locations[6].landing_page_url | https://hdl.handle.net/11577/3488170 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5015762662 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-8113-0346 |
| authorships[0].author.display_name | Annj Zamuner |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I138689650 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Civil, Environmental and Architectural Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I138689650 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[0].institutions[0].id | https://openalex.org/I138689650 |
| authorships[0].institutions[0].ror | https://ror.org/00240q980 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I138689650 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | University of Padua |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Annj Zamuner |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Civil, Environmental and Architectural Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy, Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[1].author.id | https://openalex.org/A5036906349 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-0579-229X |
| authorships[1].author.display_name | Elena Zeni |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I138689650 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[1].institutions[0].id | https://openalex.org/I138689650 |
| authorships[1].institutions[0].ror | https://ror.org/00240q980 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I138689650 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | University of Padua |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Elena Zeni |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[2].author.id | https://openalex.org/A5089365598 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-9818-4498 |
| authorships[2].author.display_name | Hamada Elsayed |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I138689650 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[2].institutions[0].id | https://openalex.org/I138689650 |
| authorships[2].institutions[0].ror | https://ror.org/00240q980 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I138689650 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | University of Padua |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Hamada Elsayed |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[3].author.id | https://openalex.org/A5027230089 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-0591-0105 |
| authorships[3].author.display_name | Michele Di Foggia |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I9360294 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy |
| authorships[3].institutions[0].id | https://openalex.org/I9360294 |
| authorships[3].institutions[0].ror | https://ror.org/01111rn36 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I9360294 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | University of Bologna |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Michele Di Foggia |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy |
| authorships[4].author.id | https://openalex.org/A5076180714 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-8478-4508 |
| authorships[4].author.display_name | Paola Taddei |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I9360294 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy |
| authorships[4].institutions[0].id | https://openalex.org/I9360294 |
| authorships[4].institutions[0].ror | https://ror.org/01111rn36 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I9360294 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | University of Bologna |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Paola Taddei |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Biomedical and Neuromotor Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy |
| authorships[5].author.id | https://openalex.org/A5032781542 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-9428-0722 |
| authorships[5].author.display_name | Antonella Pasquato |
| authorships[5].countries | IT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I138689650 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[5].institutions[0].id | https://openalex.org/I138689650 |
| authorships[5].institutions[0].ror | https://ror.org/00240q980 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I138689650 |
| authorships[5].institutions[0].country_code | IT |
| authorships[5].institutions[0].display_name | University of Padua |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Antonella Pasquato |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[6].author.id | https://openalex.org/A5033133631 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-2554-2052 |
| authorships[6].author.display_name | L. Di Silvio |
| authorships[6].countries | GB |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I183935753 |
| authorships[6].affiliations[0].raw_affiliation_string | Faculty of Dentistry, Oral & Craniofacial Sciences King’s College London, London SE1 9RT, UK |
| authorships[6].institutions[0].id | https://openalex.org/I183935753 |
| authorships[6].institutions[0].ror | https://ror.org/0220mzb33 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I183935753 |
| authorships[6].institutions[0].country_code | GB |
| authorships[6].institutions[0].display_name | King's College London |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Lucy Di Silvio |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Faculty of Dentistry, Oral & Craniofacial Sciences King’s College London, London SE1 9RT, UK |
| authorships[7].author.id | https://openalex.org/A5056476274 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-4934-4405 |
| authorships[7].author.display_name | Enrico Bernardo |
| authorships[7].countries | IT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I138689650 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[7].institutions[0].id | https://openalex.org/I138689650 |
| authorships[7].institutions[0].ror | https://ror.org/00240q980 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I138689650 |
| authorships[7].institutions[0].country_code | IT |
| authorships[7].institutions[0].display_name | University of Padua |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Enrico Bernardo |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[8].author.id | https://openalex.org/A5049641939 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-3279-9000 |
| authorships[8].author.display_name | Paola Brun |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I138689650 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Molecular Medicine, University of Padua, Via Gabelli 63, 35121 Padova, Italy |
| authorships[8].institutions[0].id | https://openalex.org/I138689650 |
| authorships[8].institutions[0].ror | https://ror.org/00240q980 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I138689650 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | University of Padua |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Paola Brun |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Molecular Medicine, University of Padua, Via Gabelli 63, 35121 Padova, Italy |
| authorships[9].author.id | https://openalex.org/A5025364009 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-6823-3375 |
| authorships[9].author.display_name | Monica Dettin |
| authorships[9].countries | IT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I138689650 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| authorships[9].institutions[0].id | https://openalex.org/I138689650 |
| authorships[9].institutions[0].ror | https://ror.org/00240q980 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I138689650 |
| authorships[9].institutions[0].country_code | IT |
| authorships[9].institutions[0].display_name | University of Padua |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Monica Dettin |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131 Padova, Italy |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2313-7673/8/2/185/pdf?version=1683191974 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Proteolytically Resistant Bioactive Peptide-Grafted Sr/Mg-Doped Hardystonite Foams: Comparison of Two Covalent Functionalization Strategies |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10059 |
| primary_topic.field.id | https://openalex.org/fields/22 |
| primary_topic.field.display_name | Engineering |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/3 |
| primary_topic.domain.display_name | Physical Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2204 |
| primary_topic.subfield.display_name | Biomedical Engineering |
| primary_topic.display_name | Bone Tissue Engineering Materials |
| related_works | https://openalex.org/W2113085998, https://openalex.org/W2538964080, https://openalex.org/W4235739070, https://openalex.org/W2351859272, https://openalex.org/W2347304581, https://openalex.org/W4254450778, https://openalex.org/W2016091062, https://openalex.org/W2372204670, https://openalex.org/W1986238109, https://openalex.org/W3092694480 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 7 |
| best_oa_location.id | doi:10.3390/biomimetics8020185 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210206423 |
| best_oa_location.source.issn | 2313-7673 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2313-7673 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Biomimetics |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2313-7673/8/2/185/pdf?version=1683191974 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Biomimetics |
| best_oa_location.landing_page_url | https://doi.org/10.3390/biomimetics8020185 |
| primary_location.id | doi:10.3390/biomimetics8020185 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210206423 |
| primary_location.source.issn | 2313-7673 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2313-7673 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Biomimetics |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2313-7673/8/2/185/pdf?version=1683191974 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Biomimetics |
| primary_location.landing_page_url | https://doi.org/10.3390/biomimetics8020185 |
| publication_date | 2023-04-29 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2345645260, https://openalex.org/W2317513811, https://openalex.org/W2076845879, https://openalex.org/W2216079337, https://openalex.org/W1572502767, https://openalex.org/W3182850335, https://openalex.org/W1552360419, https://openalex.org/W1979244926, https://openalex.org/W2145230580, https://openalex.org/W2005885719, https://openalex.org/W2104026218, https://openalex.org/W1982414211, https://openalex.org/W2520287758, https://openalex.org/W2899224461, https://openalex.org/W2615427582, https://openalex.org/W2094003039, https://openalex.org/W1968650752, https://openalex.org/W2089649420, https://openalex.org/W2120184429, https://openalex.org/W1893810620, https://openalex.org/W1993331221, https://openalex.org/W2054075535, https://openalex.org/W1964669234, https://openalex.org/W2132936019, https://openalex.org/W2017470506, https://openalex.org/W2161091595, https://openalex.org/W2172526540, https://openalex.org/W2163660121, https://openalex.org/W2114286636, https://openalex.org/W4200107503, https://openalex.org/W2051723453, https://openalex.org/W4310913872, https://openalex.org/W1977778138, https://openalex.org/W2117820636, https://openalex.org/W2019916133, https://openalex.org/W2051533595, https://openalex.org/W2038090991, https://openalex.org/W2031876019, https://openalex.org/W4283792667, https://openalex.org/W2492958053, https://openalex.org/W2021627559, https://openalex.org/W2009355445, https://openalex.org/W4214809788, https://openalex.org/W2022451964, https://openalex.org/W2327945660, https://openalex.org/W2034287320, https://openalex.org/W2071953257, https://openalex.org/W2032317416, https://openalex.org/W2030893372, https://openalex.org/W2564718652, https://openalex.org/W1974541015, https://openalex.org/W1994427044, https://openalex.org/W2304915751, https://openalex.org/W1583461005, https://openalex.org/W2025000414, https://openalex.org/W2053105182, https://openalex.org/W2152205487, https://openalex.org/W2086732438, https://openalex.org/W1984914967, https://openalex.org/W2054479973, https://openalex.org/W2076909335, https://openalex.org/W1983090947, https://openalex.org/W2031894367, https://openalex.org/W4242607571, https://openalex.org/W1971461490, https://openalex.org/W2058963609, https://openalex.org/W2005124394, https://openalex.org/W2014932842, https://openalex.org/W2143808399, https://openalex.org/W2125303614, https://openalex.org/W2017170100, https://openalex.org/W1598408991 |
| referenced_works_count | 72 |
| abstract_inverted_index.2 | 183 |
| abstract_inverted_index.6 | 149 |
| abstract_inverted_index.a | 21, 43, 118, 141 |
| abstract_inverted_index.By | 19 |
| abstract_inverted_index.HT | 75, 131 |
| abstract_inverted_index.In | 186 |
| abstract_inverted_index.To | 113 |
| abstract_inverted_index.as | 33, 94 |
| abstract_inverted_index.at | 40, 148, 182, 203 |
| abstract_inverted_index.be | 61, 194 |
| abstract_inverted_index.in | 17, 98, 144 |
| abstract_inverted_index.it | 39 |
| abstract_inverted_index.of | 10, 101, 104 |
| abstract_inverted_index.on | 67 |
| abstract_inverted_index.or | 155 |
| abstract_inverted_index.to | 56, 73, 152, 193 |
| abstract_inverted_index.we | 159 |
| abstract_inverted_index.(as | 31 |
| abstract_inverted_index.CaO | 34 |
| abstract_inverted_index.HT, | 96 |
| abstract_inverted_index.and | 13, 27, 35, 37, 52, 125, 180, 200 |
| abstract_inverted_index.any | 168 |
| abstract_inverted_index.can | 60 |
| abstract_inverted_index.for | 90, 196 |
| abstract_inverted_index.has | 49 |
| abstract_inverted_index.not | 166 |
| abstract_inverted_index.the | 82, 99, 162, 188, 205 |
| abstract_inverted_index.two | 78 |
| abstract_inverted_index.via | 7 |
| abstract_inverted_index.was | 70, 88, 128, 201 |
| abstract_inverted_index.(HT) | 1 |
| abstract_inverted_index.(via | 85, 137 |
| abstract_inverted_index.1100 | 41 |
| abstract_inverted_index.SPP1 | 181 |
| abstract_inverted_index.VTN, | 178 |
| abstract_inverted_index.Zinc | 105 |
| abstract_inverted_index.air. | 18 |
| abstract_inverted_index.days | 150, 184 |
| abstract_inverted_index.does | 165 |
| abstract_inverted_index.mild | 126 |
| abstract_inverted_index.only | 153 |
| abstract_inverted_index.over | 106 |
| abstract_inverted_index.pure | 57 |
| abstract_inverted_index.such | 93 |
| abstract_inverted_index.that | 48, 161 |
| abstract_inverted_index.this | 115, 134, 197 |
| abstract_inverted_index.well | 32 |
| abstract_inverted_index.were | 4 |
| abstract_inverted_index.with | 108, 133 |
| abstract_inverted_index.°C, | 42 |
| abstract_inverted_index.IBSP, | 177 |
| abstract_inverted_index.ZnO), | 36 |
| abstract_inverted_index.first | 83 |
| abstract_inverted_index.foams | 3, 76, 171 |
| abstract_inverted_index.human | 145 |
| abstract_inverted_index.novel | 119 |
| abstract_inverted_index.oxide | 15, 26, 29 |
| abstract_inverted_index.solid | 45 |
| abstract_inverted_index.time, | 107 |
| abstract_inverted_index.using | 20, 77 |
| abstract_inverted_index.RUNX2, | 179 |
| abstract_inverted_index.coding | 176 |
| abstract_inverted_index.easily | 5 |
| abstract_inverted_index.induce | 167 |
| abstract_inverted_index.levels | 103, 175 |
| abstract_inverted_index.mapped | 66 |
| abstract_inverted_index.method | 84 |
| abstract_inverted_index.proved | 192 |
| abstract_inverted_index.resins | 12 |
| abstract_inverted_index.second | 135, 189 |
| abstract_inverted_index.showed | 140 |
| abstract_inverted_index.aqueous | 123 |
| abstract_inverted_index.complex | 44 |
| abstract_inverted_index.fillers | 16 |
| abstract_inverted_index.grafted | 72 |
| abstract_inverted_index.peptide | 65 |
| abstract_inverted_index.release | 100 |
| abstract_inverted_index.result, | 117 |
| abstract_inverted_index.thermal | 8 |
| abstract_inverted_index.(D2HVP), | 69 |
| abstract_inverted_index.adhesive | 64 |
| abstract_inverted_index.aldehyde | 138 |
| abstract_inverted_index.cellular | 111 |
| abstract_inverted_index.compared | 55, 151 |
| abstract_inverted_index.dramatic | 142 |
| abstract_inverted_index.enhanced | 172 |
| abstract_inverted_index.increase | 143 |
| abstract_inverted_index.negative | 110 |
| abstract_inverted_index.obtained | 6 |
| abstract_inverted_index.overcome | 114 |
| abstract_inverted_index.peptide) | 87, 139 |
| abstract_inverted_index.reactive | 14 |
| abstract_inverted_index.samples. | 157 |
| abstract_inverted_index.silicone | 11 |
| abstract_inverted_index.solution | 46, 124 |
| abstract_inverted_index.specific | 198 |
| abstract_inverted_index.strategy | 121, 136, 191 |
| abstract_inverted_index.superior | 50 |
| abstract_inverted_index.treating | 38 |
| abstract_inverted_index.cytotoxic | 102 |
| abstract_inverted_index.designed. | 129 |
| abstract_inverted_index.different | 79 |
| abstract_inverted_index.effective | 202 |
| abstract_inverted_index.enhancing | 204 |
| abstract_inverted_index.magnesium | 28 |
| abstract_inverted_index.materials | 92 |
| abstract_inverted_index.obtained. | 62 |
| abstract_inverted_index.protected | 86 |
| abstract_inverted_index.requiring | 122 |
| abstract_inverted_index.response. | 112 |
| abstract_inverted_index.resulting | 97 |
| abstract_inverted_index.silanized | 154 |
| abstract_inverted_index.silicone, | 23 |
| abstract_inverted_index.strontium | 25 |
| abstract_inverted_index.treatment | 9, 164 |
| abstract_inverted_index.bioceramic | 2 |
| abstract_inverted_index.commercial | 22 |
| abstract_inverted_index.conditions | 127 |
| abstract_inverted_index.consequent | 109 |
| abstract_inverted_index.osteoblast | 146 |
| abstract_inverted_index.precursors | 30 |
| abstract_inverted_index.properties | 54 |
| abstract_inverted_index.transcript | 174 |
| abstract_inverted_index.unexpected | 116 |
| abstract_inverted_index.unsuitable | 89 |
| abstract_inverted_index.Sr/Mg-doped | 74, 95, 130 |
| abstract_inverted_index.appropriate | 195 |
| abstract_inverted_index.bioactivity | 53 |
| abstract_inverted_index.biomaterial | 199 |
| abstract_inverted_index.conclusion, | 187 |
| abstract_inverted_index.selectively | 71 |
| abstract_inverted_index.strategies. | 80 |
| abstract_inverted_index.vitronectin | 68 |
| abstract_inverted_index.(Ca2ZnSi2O7) | 59 |
| abstract_inverted_index.Furthermore, | 158 |
| abstract_inverted_index.bioactivity. | 207 |
| abstract_inverted_index.demonstrated | 160 |
| abstract_inverted_index.hardystonite | 58 |
| abstract_inverted_index.material’s | 206 |
| abstract_inverted_index.cytotoxicity. | 169 |
| abstract_inverted_index.incorporating | 24 |
| abstract_inverted_index.mRNA-specific | 173 |
| abstract_inverted_index.post-seeding. | 185 |
| abstract_inverted_index.proliferation | 147 |
| abstract_inverted_index.Functionalized | 170 |
| abstract_inverted_index.Unfortunately, | 81 |
| abstract_inverted_index.acid-sensitive | 91 |
| abstract_inverted_index.functionalized | 132 |
| abstract_inverted_index.biocompatibility | 51 |
| abstract_inverted_index.functionalization | 120, 163, 190 |
| abstract_inverted_index.Hardystonite-based | 0 |
| abstract_inverted_index.non-functionalized | 156 |
| abstract_inverted_index.Proteolytic-resistant | 63 |
| abstract_inverted_index.(Ca1.4Sr0.6Zn0.85Mg0.15Si2O7) | 47 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5015762662 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I138689650 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.5199999809265137 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.49375026 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |