Proteome‐Guided Drug Target Discovery for Periodontitis Article Swipe
Zoheir Alayash
,
Sebastian‐Edgar Baumeister
,
Birte Holtfreter
,
Thomas Kocher
,
Hansjörg Baurecht
,
Benjamin Ehmke
,
Daniel Hagenfeld
,
Stefan Lars Reckelkamm
,
Michael Nolde
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/jcpe.70032
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/jcpe.70032
Background and Objective Periodontitis is a chronic inflammatory disease driven by immune dysfunction and microbial imbalance. This study aims to identify circulating druggable proteins causally linked to the disease. Materials and Methods We integrated proteomics data from deCODE genetics with periodontitis genome‐wide association studies (GWAS) from the Million Veteran Program to identify proteins associated with periodontitis. Findings were replicated using GWAS data from the Gene‐Lifestyle Interactions in Dental Endpoints consortium. Causal associations were validated using genetic and statistical methods, and the identified proteins were assessed for biological relevance and druggability. Results Among the 2088 evaluated proteins, three showed robust evidence of causal association with periodontitis: FGF2 (fibroblast growth factor 2) (odds ratio [OR]: 1.06, 95% confidence interval [CI] 1.032–1.082), AZGP1 (zinc‐alpha‐2‐glycoprotein) (OR: 1.12, 95% CI 1.058–1.189) and BTC (betacellulin) (OR: 0.86, 95% CI 0.789–0.942). Replication analysis confirmed associations for 18 proteins, with 16 showing high colocalisation. Further evaluation of drug target databases revealed indirect links between the identified proteins and approved therapies for inflammatory conditions, suggesting potential therapeutic relevance. Conclusion This study identifies three circulating proteins—FGF2, AZGP1 and BTC—as causally associated with periodontitis, highlighting their potential as therapeutic targets. These results provide a foundation for future research into targeted therapies for periodontitis.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/jcpe.70032
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcpe.70032
- OA Status
- hybrid
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4414032707
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4414032707Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/jcpe.70032Digital Object Identifier
- Title
-
Proteome‐Guided Drug Target Discovery for PeriodontitisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-09-05Full publication date if available
- Authors
-
Zoheir Alayash, Sebastian‐Edgar Baumeister, Birte Holtfreter, Thomas Kocher, Hansjörg Baurecht, Benjamin Ehmke, Daniel Hagenfeld, Stefan Lars Reckelkamm, Michael NoldeList of authors in order
- Landing page
-
https://doi.org/10.1111/jcpe.70032Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcpe.70032Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcpe.70032Direct OA link when available
- Concepts
-
Drug discovery, Periodontitis, Computational biology, Proteome, Medicine, Drug, Bioinformatics, Biology, Dentistry, PharmacologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
58Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4414032707 |
|---|---|
| doi | https://doi.org/10.1111/jcpe.70032 |
| ids.doi | https://doi.org/10.1111/jcpe.70032 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40913361 |
| ids.openalex | https://openalex.org/W4414032707 |
| fwci | 0.0 |
| type | article |
| title | Proteome‐Guided Drug Target Discovery for Periodontitis |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| grants[0].funder | https://openalex.org/F4320320879 |
| grants[0].award_id | 541494246 |
| grants[0].funder_display_name | Deutsche Forschungsgemeinschaft |
| topics[0].id | https://openalex.org/T10257 |
| topics[0].field.id | https://openalex.org/fields/35 |
| topics[0].field.display_name | Dentistry |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/3506 |
| topics[0].subfield.display_name | Periodontics |
| topics[0].display_name | Oral microbiology and periodontitis research |
| topics[1].id | https://openalex.org/T11452 |
| topics[1].field.id | https://openalex.org/fields/35 |
| topics[1].field.display_name | Dentistry |
| topics[1].score | 0.9925000071525574 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/3506 |
| topics[1].subfield.display_name | Periodontics |
| topics[1].display_name | Oral Health Pathology and Treatment |
| topics[2].id | https://openalex.org/T11521 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9854999780654907 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2737 |
| topics[2].subfield.display_name | Physiology |
| topics[2].display_name | Salivary Gland Disorders and Functions |
| funders[0].id | https://openalex.org/F4320320879 |
| funders[0].ror | https://ror.org/018mejw64 |
| funders[0].display_name | Deutsche Forschungsgemeinschaft |
| is_xpac | False |
| apc_list.value | 5050 |
| apc_list.currency | USD |
| apc_list.value_usd | 5050 |
| apc_paid.value | 5050 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 5050 |
| concepts[0].id | https://openalex.org/C74187038 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7525244355201721 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1418791 |
| concepts[0].display_name | Drug discovery |
| concepts[1].id | https://openalex.org/C2780385504 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7303817272186279 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q520127 |
| concepts[1].display_name | Periodontitis |
| concepts[2].id | https://openalex.org/C70721500 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5460546016693115 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[2].display_name | Computational biology |
| concepts[3].id | https://openalex.org/C104397665 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5266482830047607 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q860947 |
| concepts[3].display_name | Proteome |
| concepts[4].id | https://openalex.org/C71924100 |
| concepts[4].level | 0 |
| concepts[4].score | 0.5186297297477722 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[4].display_name | Medicine |
| concepts[5].id | https://openalex.org/C2780035454 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5107231140136719 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q8386 |
| concepts[5].display_name | Drug |
| concepts[6].id | https://openalex.org/C60644358 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3681598901748657 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q128570 |
| concepts[6].display_name | Bioinformatics |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.2899656891822815 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C199343813 |
| concepts[8].level | 1 |
| concepts[8].score | 0.23724254965782166 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q12128 |
| concepts[8].display_name | Dentistry |
| concepts[9].id | https://openalex.org/C98274493 |
| concepts[9].level | 1 |
| concepts[9].score | 0.20313915610313416 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[9].display_name | Pharmacology |
| keywords[0].id | https://openalex.org/keywords/drug-discovery |
| keywords[0].score | 0.7525244355201721 |
| keywords[0].display_name | Drug discovery |
| keywords[1].id | https://openalex.org/keywords/periodontitis |
| keywords[1].score | 0.7303817272186279 |
| keywords[1].display_name | Periodontitis |
| keywords[2].id | https://openalex.org/keywords/computational-biology |
| keywords[2].score | 0.5460546016693115 |
| keywords[2].display_name | Computational biology |
| keywords[3].id | https://openalex.org/keywords/proteome |
| keywords[3].score | 0.5266482830047607 |
| keywords[3].display_name | Proteome |
| keywords[4].id | https://openalex.org/keywords/medicine |
| keywords[4].score | 0.5186297297477722 |
| keywords[4].display_name | Medicine |
| keywords[5].id | https://openalex.org/keywords/drug |
| keywords[5].score | 0.5107231140136719 |
| keywords[5].display_name | Drug |
| keywords[6].id | https://openalex.org/keywords/bioinformatics |
| keywords[6].score | 0.3681598901748657 |
| keywords[6].display_name | Bioinformatics |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.2899656891822815 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/dentistry |
| keywords[8].score | 0.23724254965782166 |
| keywords[8].display_name | Dentistry |
| keywords[9].id | https://openalex.org/keywords/pharmacology |
| keywords[9].score | 0.20313915610313416 |
| keywords[9].display_name | Pharmacology |
| language | en |
| locations[0].id | doi:10.1111/jcpe.70032 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S61859066 |
| locations[0].source.issn | 0303-6979, 1600-051X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0303-6979 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal Of Clinical Periodontology |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcpe.70032 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Clinical Periodontology |
| locations[0].landing_page_url | https://doi.org/10.1111/jcpe.70032 |
| locations[1].id | pmid:40913361 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of clinical periodontology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40913361 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5030540674 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-6850-5668 |
| authorships[0].author.display_name | Zoheir Alayash |
| authorships[0].countries | DE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I22465464 |
| authorships[0].affiliations[0].raw_affiliation_string | Institute of Health Services Research in Dentistry University of Münster Münster Germany |
| authorships[0].institutions[0].id | https://openalex.org/I22465464 |
| authorships[0].institutions[0].ror | https://ror.org/00pd74e08 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I22465464 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | University of Münster |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Zoheir Alayash |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Institute of Health Services Research in Dentistry University of Münster Münster Germany |
| authorships[1].author.id | https://openalex.org/A5075278887 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-9391-6602 |
| authorships[1].author.display_name | Sebastian‐Edgar Baumeister |
| authorships[1].countries | DE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I22465464 |
| authorships[1].affiliations[0].raw_affiliation_string | Institute of Health Services Research in Dentistry University of Münster Münster Germany |
| authorships[1].institutions[0].id | https://openalex.org/I22465464 |
| authorships[1].institutions[0].ror | https://ror.org/00pd74e08 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I22465464 |
| authorships[1].institutions[0].country_code | DE |
| authorships[1].institutions[0].display_name | University of Münster |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Sebastian‐Edgar Baumeister |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institute of Health Services Research in Dentistry University of Münster Münster Germany |
| authorships[2].author.id | https://openalex.org/A5006484525 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6541-3127 |
| authorships[2].author.display_name | Birte Holtfreter |
| authorships[2].countries | DE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2799318839 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany |
| authorships[2].institutions[0].id | https://openalex.org/I2799318839 |
| authorships[2].institutions[0].ror | https://ror.org/025vngs54 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I2799318839 |
| authorships[2].institutions[0].country_code | DE |
| authorships[2].institutions[0].display_name | Universitätsmedizin Greifswald |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Birte Holtfreter |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany |
| authorships[3].author.id | https://openalex.org/A5059371186 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9605-2822 |
| authorships[3].author.display_name | Thomas Kocher |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2799318839 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany |
| authorships[3].institutions[0].id | https://openalex.org/I2799318839 |
| authorships[3].institutions[0].ror | https://ror.org/025vngs54 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I2799318839 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | Universitätsmedizin Greifswald |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Thomas Kocher |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany |
| authorships[4].author.id | https://openalex.org/A5021543281 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-9265-5594 |
| authorships[4].author.display_name | Hansjörg Baurecht |
| authorships[4].countries | DE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I60668342 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany |
| authorships[4].institutions[0].id | https://openalex.org/I60668342 |
| authorships[4].institutions[0].ror | https://ror.org/01eezs655 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I60668342 |
| authorships[4].institutions[0].country_code | DE |
| authorships[4].institutions[0].display_name | University of Regensburg |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Hansjörg Baurecht |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany |
| authorships[5].author.id | https://openalex.org/A5054502788 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-2418-6765 |
| authorships[5].author.display_name | Benjamin Ehmke |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I22465464 |
| authorships[5].affiliations[0].raw_affiliation_string | Clinic for Periodontology and Conservative Dentistry University of Münster Münster Germany |
| authorships[5].institutions[0].id | https://openalex.org/I22465464 |
| authorships[5].institutions[0].ror | https://ror.org/00pd74e08 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I22465464 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | University of Münster |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Benjamin Ehmke |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Clinic for Periodontology and Conservative Dentistry University of Münster Münster Germany |
| authorships[6].author.id | https://openalex.org/A5070465551 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-1072-4865 |
| authorships[6].author.display_name | Daniel Hagenfeld |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I22465464 |
| authorships[6].affiliations[0].raw_affiliation_string | Clinic for Periodontology and Conservative Dentistry University of Münster Münster Germany |
| authorships[6].institutions[0].id | https://openalex.org/I22465464 |
| authorships[6].institutions[0].ror | https://ror.org/00pd74e08 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I22465464 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | University of Münster |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Daniel Hagenfeld |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Clinic for Periodontology and Conservative Dentistry University of Münster Münster Germany |
| authorships[7].author.id | https://openalex.org/A5009174858 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-5273-7288 |
| authorships[7].author.display_name | Stefan Lars Reckelkamm |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I22465464 |
| authorships[7].affiliations[0].raw_affiliation_string | Clinic for Periodontology and Conservative Dentistry University of Münster Münster Germany |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I22465464 |
| authorships[7].affiliations[1].raw_affiliation_string | Institute of Health Services Research in Dentistry University of Münster Münster Germany |
| authorships[7].institutions[0].id | https://openalex.org/I22465464 |
| authorships[7].institutions[0].ror | https://ror.org/00pd74e08 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I22465464 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | University of Münster |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Stefan Lars Reckelkamm |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Clinic for Periodontology and Conservative Dentistry University of Münster Münster Germany, Institute of Health Services Research in Dentistry University of Münster Münster Germany |
| authorships[8].author.id | https://openalex.org/A5029487649 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-6893-7367 |
| authorships[8].author.display_name | Michael Nolde |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I22465464 |
| authorships[8].affiliations[0].raw_affiliation_string | Institute of Health Services Research in Dentistry University of Münster Münster Germany |
| authorships[8].institutions[0].id | https://openalex.org/I22465464 |
| authorships[8].institutions[0].ror | https://ror.org/00pd74e08 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I22465464 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | University of Münster |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Michael Nolde |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Institute of Health Services Research in Dentistry University of Münster Münster Germany |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcpe.70032 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Proteome‐Guided Drug Target Discovery for Periodontitis |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10257 |
| primary_topic.field.id | https://openalex.org/fields/35 |
| primary_topic.field.display_name | Dentistry |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/3506 |
| primary_topic.subfield.display_name | Periodontics |
| primary_topic.display_name | Oral microbiology and periodontitis research |
| related_works | https://openalex.org/W2556855892, https://openalex.org/W4280541024, https://openalex.org/W4214810602, https://openalex.org/W2523769397, https://openalex.org/W2000687555, https://openalex.org/W2158546283, https://openalex.org/W2255897055, https://openalex.org/W2013600324, https://openalex.org/W2924545821, https://openalex.org/W2467797731 |
| cited_by_count | 0 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1111/jcpe.70032 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S61859066 |
| best_oa_location.source.issn | 0303-6979, 1600-051X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0303-6979 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Journal Of Clinical Periodontology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcpe.70032 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Clinical Periodontology |
| best_oa_location.landing_page_url | https://doi.org/10.1111/jcpe.70032 |
| primary_location.id | doi:10.1111/jcpe.70032 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S61859066 |
| primary_location.source.issn | 0303-6979, 1600-051X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0303-6979 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal Of Clinical Periodontology |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcpe.70032 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Clinical Periodontology |
| primary_location.landing_page_url | https://doi.org/10.1111/jcpe.70032 |
| publication_date | 2025-09-05 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4233298213, https://openalex.org/W4388399359, https://openalex.org/W3049361680, https://openalex.org/W2082344308, https://openalex.org/W2991007563, https://openalex.org/W2900668971, https://openalex.org/W2950591584, https://openalex.org/W2341823820, https://openalex.org/W1911952697, https://openalex.org/W2073836327, https://openalex.org/W2101070690, https://openalex.org/W3012590737, https://openalex.org/W2040836984, https://openalex.org/W4404288944, https://openalex.org/W2156288673, https://openalex.org/W2119102689, https://openalex.org/W2081257201, https://openalex.org/W4393640955, https://openalex.org/W4403203279, https://openalex.org/W4399134120, https://openalex.org/W3023972696, https://openalex.org/W2108966355, https://openalex.org/W2022142238, https://openalex.org/W4401968324, https://openalex.org/W2118822739, https://openalex.org/W2189216207, https://openalex.org/W2131684681, https://openalex.org/W2901952863, https://openalex.org/W1988264011, https://openalex.org/W3021393259, https://openalex.org/W3081351409, https://openalex.org/W2104042033, https://openalex.org/W2064720560, https://openalex.org/W2606491090, https://openalex.org/W2466050300, https://openalex.org/W4200006128, https://openalex.org/W4400770247, https://openalex.org/W3016210993, https://openalex.org/W4410765112, https://openalex.org/W4392884770, https://openalex.org/W4396807134, https://openalex.org/W3011782484, https://openalex.org/W3013302440, https://openalex.org/W2328393125, https://openalex.org/W3125030132, https://openalex.org/W2097137621, https://openalex.org/W275754419, https://openalex.org/W2945665018, https://openalex.org/W3123744360, https://openalex.org/W3164541010, https://openalex.org/W3215894083, https://openalex.org/W2161512797, https://openalex.org/W2897037806, https://openalex.org/W2005343620, https://openalex.org/W2787729717, https://openalex.org/W1942877698, https://openalex.org/W4315754584, https://openalex.org/W2170411910 |
| referenced_works_count | 58 |
| abstract_inverted_index.a | 6, 193 |
| abstract_inverted_index.16 | 143 |
| abstract_inverted_index.18 | 140 |
| abstract_inverted_index.2) | 110 |
| abstract_inverted_index.CI | 125, 133 |
| abstract_inverted_index.We | 33 |
| abstract_inverted_index.as | 187 |
| abstract_inverted_index.by | 11 |
| abstract_inverted_index.in | 67 |
| abstract_inverted_index.is | 5 |
| abstract_inverted_index.of | 101, 149 |
| abstract_inverted_index.to | 20, 27, 51 |
| abstract_inverted_index.95% | 115, 124, 132 |
| abstract_inverted_index.BTC | 128 |
| abstract_inverted_index.and | 2, 14, 31, 77, 80, 89, 127, 160, 178 |
| abstract_inverted_index.for | 86, 139, 163, 195, 201 |
| abstract_inverted_index.the | 28, 47, 64, 81, 93, 157 |
| abstract_inverted_index.(OR: | 122, 130 |
| abstract_inverted_index.2088 | 94 |
| abstract_inverted_index.FGF2 | 106 |
| abstract_inverted_index.GWAS | 61 |
| abstract_inverted_index.This | 17, 171 |
| abstract_inverted_index.[CI] | 118 |
| abstract_inverted_index.aims | 19 |
| abstract_inverted_index.data | 36, 62 |
| abstract_inverted_index.drug | 150 |
| abstract_inverted_index.from | 37, 46, 63 |
| abstract_inverted_index.high | 145 |
| abstract_inverted_index.into | 198 |
| abstract_inverted_index.were | 58, 73, 84 |
| abstract_inverted_index.with | 40, 55, 104, 142, 182 |
| abstract_inverted_index.(odds | 111 |
| abstract_inverted_index.0.86, | 131 |
| abstract_inverted_index.1.06, | 114 |
| abstract_inverted_index.1.12, | 123 |
| abstract_inverted_index.AZGP1 | 120, 177 |
| abstract_inverted_index.Among | 92 |
| abstract_inverted_index.These | 190 |
| abstract_inverted_index.[OR]: | 113 |
| abstract_inverted_index.links | 155 |
| abstract_inverted_index.ratio | 112 |
| abstract_inverted_index.study | 18, 172 |
| abstract_inverted_index.their | 185 |
| abstract_inverted_index.three | 97, 174 |
| abstract_inverted_index.using | 60, 75 |
| abstract_inverted_index.(GWAS) | 45 |
| abstract_inverted_index.Causal | 71 |
| abstract_inverted_index.Dental | 68 |
| abstract_inverted_index.causal | 102 |
| abstract_inverted_index.deCODE | 38 |
| abstract_inverted_index.driven | 10 |
| abstract_inverted_index.factor | 109 |
| abstract_inverted_index.future | 196 |
| abstract_inverted_index.growth | 108 |
| abstract_inverted_index.immune | 12 |
| abstract_inverted_index.linked | 26 |
| abstract_inverted_index.robust | 99 |
| abstract_inverted_index.showed | 98 |
| abstract_inverted_index.target | 151 |
| abstract_inverted_index.Further | 147 |
| abstract_inverted_index.Methods | 32 |
| abstract_inverted_index.Million | 48 |
| abstract_inverted_index.Program | 50 |
| abstract_inverted_index.Results | 91 |
| abstract_inverted_index.Veteran | 49 |
| abstract_inverted_index.between | 156 |
| abstract_inverted_index.chronic | 7 |
| abstract_inverted_index.disease | 9 |
| abstract_inverted_index.genetic | 76 |
| abstract_inverted_index.provide | 192 |
| abstract_inverted_index.results | 191 |
| abstract_inverted_index.showing | 144 |
| abstract_inverted_index.studies | 44 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.BTC—as | 179 |
| abstract_inverted_index.Findings | 57 |
| abstract_inverted_index.analysis | 136 |
| abstract_inverted_index.approved | 161 |
| abstract_inverted_index.assessed | 85 |
| abstract_inverted_index.causally | 25, 180 |
| abstract_inverted_index.disease. | 29 |
| abstract_inverted_index.evidence | 100 |
| abstract_inverted_index.genetics | 39 |
| abstract_inverted_index.identify | 21, 52 |
| abstract_inverted_index.indirect | 154 |
| abstract_inverted_index.interval | 117 |
| abstract_inverted_index.methods, | 79 |
| abstract_inverted_index.proteins | 24, 53, 83, 159 |
| abstract_inverted_index.research | 197 |
| abstract_inverted_index.revealed | 153 |
| abstract_inverted_index.targeted | 199 |
| abstract_inverted_index.targets. | 189 |
| abstract_inverted_index.Endpoints | 69 |
| abstract_inverted_index.Materials | 30 |
| abstract_inverted_index.Objective | 3 |
| abstract_inverted_index.confirmed | 137 |
| abstract_inverted_index.databases | 152 |
| abstract_inverted_index.druggable | 23 |
| abstract_inverted_index.evaluated | 95 |
| abstract_inverted_index.microbial | 15 |
| abstract_inverted_index.potential | 167, 186 |
| abstract_inverted_index.proteins, | 96, 141 |
| abstract_inverted_index.relevance | 88 |
| abstract_inverted_index.therapies | 162, 200 |
| abstract_inverted_index.validated | 74 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Conclusion | 170 |
| abstract_inverted_index.associated | 54, 181 |
| abstract_inverted_index.biological | 87 |
| abstract_inverted_index.confidence | 116 |
| abstract_inverted_index.evaluation | 148 |
| abstract_inverted_index.foundation | 194 |
| abstract_inverted_index.identified | 82, 158 |
| abstract_inverted_index.identifies | 173 |
| abstract_inverted_index.imbalance. | 16 |
| abstract_inverted_index.integrated | 34 |
| abstract_inverted_index.proteomics | 35 |
| abstract_inverted_index.relevance. | 169 |
| abstract_inverted_index.replicated | 59 |
| abstract_inverted_index.suggesting | 166 |
| abstract_inverted_index.(fibroblast | 107 |
| abstract_inverted_index.Replication | 135 |
| abstract_inverted_index.association | 43, 103 |
| abstract_inverted_index.circulating | 22, 175 |
| abstract_inverted_index.conditions, | 165 |
| abstract_inverted_index.consortium. | 70 |
| abstract_inverted_index.dysfunction | 13 |
| abstract_inverted_index.statistical | 78 |
| abstract_inverted_index.therapeutic | 168, 188 |
| abstract_inverted_index.Interactions | 66 |
| abstract_inverted_index.associations | 72, 138 |
| abstract_inverted_index.highlighting | 184 |
| abstract_inverted_index.inflammatory | 8, 164 |
| abstract_inverted_index.Periodontitis | 4 |
| abstract_inverted_index.druggability. | 90 |
| abstract_inverted_index.genome‐wide | 42 |
| abstract_inverted_index.periodontitis | 41 |
| abstract_inverted_index.(betacellulin) | 129 |
| abstract_inverted_index.1.058–1.189) | 126 |
| abstract_inverted_index.periodontitis, | 183 |
| abstract_inverted_index.periodontitis. | 56, 202 |
| abstract_inverted_index.periodontitis: | 105 |
| abstract_inverted_index.0.789–0.942). | 134 |
| abstract_inverted_index.1.032–1.082), | 119 |
| abstract_inverted_index.colocalisation. | 146 |
| abstract_inverted_index.Gene‐Lifestyle | 65 |
| abstract_inverted_index.proteins—FGF2, | 176 |
| abstract_inverted_index.(zinc‐alpha‐2‐glycoprotein) | 121 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5030540674 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I22465464 |
| citation_normalized_percentile.value | 0.48959366 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |