Proteomics of Extracellular Vesicles: Recent Updates, Challenges and Limitations Article Swipe
Mohini Singh
,
Prashant Kumar Tiwari
,
Vivek K. Kashyap
,
Sanjay Kumar
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/proteomes13010012
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/proteomes13010012
Extracellular vesicles (EVs) are lipid-bound vesicles secreted by cells, including exosomes, microvesicles, and apoptotic bodies. Proteomic analyses of EVs, particularly in relation to cancer, reveal specific biomarkers crucial for diagnosis and therapy. However, isolation techniques such as ultracentrifugation, size-exclusion chromatography, and ultrafiltration face challenges regarding purity, contamination, and yield. Contamination from other proteins complicates downstream processing, leading to difficulties in identifying biomarkers and interpreting results. Future research will focus on refining EV characterization for diagnostic and therapeutic applications, improving proteomics tools for greater accuracy, and exploring the use of EVs in drug delivery and regenerative medicine. In this review, we provide a bird’s eye view of various challenges, starting with EV isolation methods, yield, purity, and limitations in the proteome analysis of EVs for identifying protein targets.
Related Topics
Concepts
Extracellular vesicles
Microvesicles
Proteomics
Computational biology
Proteome
Ultrafiltration (renal)
Nanoparticle tracking analysis
Extracellular vesicle
Exosome
Biology
Chemistry
Nanotechnology
Bioinformatics
Cell biology
microRNA
Biochemistry
Materials science
Gene
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/proteomes13010012
- https://www.mdpi.com/2227-7382/13/1/12/pdf?version=1741072946
- OA Status
- gold
- Cited By
- 8
- References
- 105
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408157246
All OpenAlex metadata
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- DOI
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https://doi.org/10.3390/proteomes13010012Digital Object Identifier
- Title
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Proteomics of Extracellular Vesicles: Recent Updates, Challenges and LimitationsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-03-04Full publication date if available
- Authors
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Mohini Singh, Prashant Kumar Tiwari, Vivek K. Kashyap, Sanjay KumarList of authors in order
- Landing page
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https://doi.org/10.3390/proteomes13010012Publisher landing page
- PDF URL
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https://www.mdpi.com/2227-7382/13/1/12/pdf?version=1741072946Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2227-7382/13/1/12/pdf?version=1741072946Direct OA link when available
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Extracellular vesicles, Microvesicles, Proteomics, Computational biology, Proteome, Ultrafiltration (renal), Nanoparticle tracking analysis, Extracellular vesicle, Exosome, Biology, Chemistry, Nanotechnology, Bioinformatics, Cell biology, microRNA, Biochemistry, Materials science, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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