Protocol for a multi-country retrospective observational paediatric sepsis epidemiological study (SENTINEL International) Article Swipe
Elliot Long
,
Amanda Williams
,
Shane George
,
Stephen Hearps
,
Adriana Yock‐Corrales
,
Viviana Pavlicich
,
Kandamaran Krishnamurthy
,
Yashica Seymour-Hanna
,
Radhika Raman
,
Bharat Choudhary
,
Weda Kusuma
,
Victoria Ribaya
,
Nilanka Mudithakumara
,
Nichkamol Lertamornkittior
,
Anthony S. David
,
S. Mohamed
,
Tigist Bacha
,
Jenala Njirammadzi-Maleta
,
John Adabie Appiah
,
Janvier Hitayezu
,
Mukami Kunga
,
Genevieve P. G. Fung
,
Rahimi Abdrazak
,
Shu‐Ling Chong
,
Jhong-Lin Wu
,
Jeong‐Yong Lee
,
Damian Roland
,
Silvia Bressan
,
Ruth Loellgen
,
Yolanda Ballestero
,
Özlem Tekşam
,
Lina Jankauskaitė
,
Graham C. Thompson
,
Vikram Sabhaney
,
Yasaman Shayan
,
Elysha Pifko
,
Julia Lloyd
,
Khalid Al Ansari
,
Franz E Babl
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2025-101332
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2025-101332
Introduction Improving outcomes from sepsis in children is a WHO Global Health Priority, yet mortality from sepsis remains high, particularly in low- and middle-income countries (LMICs). This database from children with community-acquired childhood sepsis in LMICs and some high-income countries will allow analysis of the burden of disease, including incidence, severity and outcomes. Understanding these aspects of sepsis care is fundamental for the design and conduct of future international interventional trials to improve childhood sepsis outcomes. Methods and analysis This multicountry retrospective observational study will include children up to 18 years of age presenting to emergency departments with suspected sepsis, defined as admission to hospital for treatment with intravenous antibiotics plus (1) a provisional diagnosis of sepsis and/or (2) treatment for suspected sepsis (operationalised as the administration of one or more fluid bolus to treat impaired perfusion or vasoactive infusion). Presenting characteristics, management and outcomes will be collected. These will include vital signs, serum biomarkers, intravenous fluid administration for the first 24 hours of hospitalisation, organ support therapies delivered, antimicrobial use, microbiological diagnoses, hospital and intensive care unit length of stay, and mortality censored at hospital discharge or 30 days from enrolment (whichever occurs first). Ethics and dissemination Central ethics approval was received from the Royal Children’s Hospital of Melbourne, Australia Human Research Ethics Committee (HREC/100648/RCHM-2023). Each international site will be required to obtain local Institutional Research Ethics Board approval. The findings will be disseminated in peer-reviewed journals, at academic conferences and through lay media. A cleaned study database and individual site-level data will be made available to site investigators upon completion of the study. Trial registration number This study was registered with the Australian and New Zealand Clinical Trials Registry on 23 January 2024 prior to commencement of recruitment (ACTRN12624000052538).
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/bmjopen-2025-101332
- https://bmjopen.bmj.com/content/bmjopen/15/10/e101332.full.pdf
- OA Status
- gold
- References
- 29
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4415279715Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1136/bmjopen-2025-101332Digital Object Identifier
- Title
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Protocol for a multi-country retrospective observational paediatric sepsis epidemiological study (SENTINEL International)Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-10-01Full publication date if available
- Authors
-
Elliot Long, Amanda Williams, Shane George, Stephen Hearps, Adriana Yock‐Corrales, Viviana Pavlicich, Kandamaran Krishnamurthy, Yashica Seymour-Hanna, Radhika Raman, Bharat Choudhary, Weda Kusuma, Victoria Ribaya, Nilanka Mudithakumara, Nichkamol Lertamornkittior, Anthony S. David, S. Mohamed, Tigist Bacha, Jenala Njirammadzi-Maleta, John Adabie Appiah, Janvier Hitayezu, Mukami Kunga, Genevieve P. G. Fung, Rahimi Abdrazak, Shu‐Ling Chong, Jhong-Lin Wu, Jeong‐Yong Lee, Damian Roland, Silvia Bressan, Ruth Loellgen, Yolanda Ballestero, Özlem Tekşam, Lina Jankauskaitė, Graham C. Thompson, Vikram Sabhaney, Yasaman Shayan, Elysha Pifko, Julia Lloyd, Khalid Al Ansari, Franz E BablList of authors in order
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https://doi.org/10.1136/bmjopen-2025-101332Publisher landing page
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https://bmjopen.bmj.com/content/bmjopen/15/10/e101332.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://bmjopen.bmj.com/content/bmjopen/15/10/e101332.full.pdfDirect OA link when available
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