PROX1 is a specific and dynamic marker of sacral neural crest cells in the chicken intestine Article Swipe
Andreia S. Margarido
,
Ludovic Le Guen
,
Amandine Falco
,
Sandrine Faure
,
Norbert Chauvet
,
Pascal de Santa Barbara
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1002/cne.24801
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1002/cne.24801
The enteric nervous system (ENS) is a complex network constituted of neurons and glial cells that ensures the intrinsic innervation of the gastrointestinal tract. ENS cells originate from vagal and sacral neural crest cells that are initially located at the border of the neural tube. In birds, sacral neural crest cells (sNCCs) first give rise to an extramural ganglionated structure (the so‐called Nerve of Remak [NoR]) and to the pelvic plexus. Later, sNCCs enter the colon mesenchyme to colonize and contribute to the intrinsic innervation of the caudal part of the gut. However, no specific sNCC marker has been described. Here, we report the expression pattern of prospero‐related homeobox 1 (PROX1) in the developing chick colon. PROX1 is a homeobox domain transcription factor that plays a role in cell type specification in various tissues. Using in situ hybridization and immunofluorescence techniques, we showed that PROX1 is expressed in sNCCs localized in the NoR and in the pelvic plexus. Then, using real‐time quantitative PCR we found that PROX1 displays a strong and highly dynamic expression pattern during NoR development. Moreover, we demonstrated using in vivo cell tracing, that sNCCs are the source of the PROX1‐positive cells within the NoR. Our results indicate that PROX1 is the first marker that specifically identifies sNCCs. This might help to better identify the role of the different neural crest cell populations in distal gut innervation, and consequently to improve the diagnosis of diseases linked to incomplete ENS formation, such as Hirschsprung's disease.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/cne.24801
- OA Status
- green
- Cited By
- 5
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2982509325
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2982509325Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/cne.24801Digital Object Identifier
- Title
-
PROX1 is a specific and dynamic marker of sacral neural crest cells in the chicken intestineWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-10-28Full publication date if available
- Authors
-
Andreia S. Margarido, Ludovic Le Guen, Amandine Falco, Sandrine Faure, Norbert Chauvet, Pascal de Santa BarbaraList of authors in order
- Landing page
-
https://doi.org/10.1002/cne.24801Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://hal.science/hal-02332399Direct OA link when available
- Concepts
-
Biology, Neural crest, Anatomy, Neuroscience, Cell biology, EmbryoTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2023: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
60Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2982509325 |
|---|---|
| doi | https://doi.org/10.1002/cne.24801 |
| ids.doi | https://doi.org/10.1002/cne.24801 |
| ids.mag | 2982509325 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/31658363 |
| ids.openalex | https://openalex.org/W2982509325 |
| fwci | 0.27201919 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D015415 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Biomarkers |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D002642 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Chick Embryo |
| mesh[3].qualifier_ui | Q000166 |
| mesh[3].descriptor_ui | D017615 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | cytology |
| mesh[3].descriptor_name | Enteric Nervous System |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D018398 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Homeodomain Proteins |
| mesh[5].qualifier_ui | Q000294 |
| mesh[5].descriptor_ui | D007422 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | innervation |
| mesh[5].descriptor_name | Intestines |
| mesh[6].qualifier_ui | Q000166 |
| mesh[6].descriptor_ui | D009432 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | cytology |
| mesh[6].descriptor_name | Neural Crest |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D009432 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Neural Crest |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D000818 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Animals |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D015415 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Biomarkers |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D002642 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Chick Embryo |
| mesh[11].qualifier_ui | Q000166 |
| mesh[11].descriptor_ui | D017615 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | cytology |
| mesh[11].descriptor_name | Enteric Nervous System |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D018398 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Homeodomain Proteins |
| mesh[13].qualifier_ui | Q000294 |
| mesh[13].descriptor_ui | D007422 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | innervation |
| mesh[13].descriptor_name | Intestines |
| mesh[14].qualifier_ui | Q000166 |
| mesh[14].descriptor_ui | D009432 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | cytology |
| mesh[14].descriptor_name | Neural Crest |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D009432 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Neural Crest |
| type | article |
| title | PROX1 is a specific and dynamic marker of sacral neural crest cells in the chicken intestine |
| awards[0].id | https://openalex.org/G6888953610 |
| awards[0].funder_id | https://openalex.org/F4320309751 |
| awards[0].display_name | |
| awards[0].funder_award_id | 18766 |
| awards[0].funder_display_name | Association Française contre les Myopathies |
| awards[1].id | https://openalex.org/G4307451785 |
| awards[1].funder_id | https://openalex.org/F4320309751 |
| awards[1].display_name | |
| awards[1].funder_award_id | 15681 |
| awards[1].funder_display_name | Association Française contre les Myopathies |
| awards[2].id | https://openalex.org/G4542801057 |
| awards[2].funder_id | https://openalex.org/F4320309751 |
| awards[2].display_name | |
| awards[2].funder_award_id | 20749 |
| awards[2].funder_display_name | Association Française contre les Myopathies |
| awards[3].id | https://openalex.org/G8625361910 |
| awards[3].funder_id | https://openalex.org/F4320322361 |
| awards[3].display_name | |
| awards[3].funder_award_id | ARC post‐doctoral fellowship |
| awards[3].funder_display_name | Fondation ARC pour la Recherche sur le Cancer |
| biblio.issue | 5 |
| biblio.volume | 528 |
| biblio.last_page | 889 |
| biblio.first_page | 879 |
| topics[0].id | https://openalex.org/T12237 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9986000061035156 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2746 |
| topics[0].subfield.display_name | Surgery |
| topics[0].display_name | Congenital gastrointestinal and neural anomalies |
| funders[0].id | https://openalex.org/F4320309751 |
| funders[0].ror | https://ror.org/0162y2387 |
| funders[0].display_name | Association Française contre les Myopathies |
| funders[1].id | https://openalex.org/F4320322361 |
| funders[1].ror | https://ror.org/0489qz649 |
| funders[1].display_name | Fondation ARC pour la Recherche sur le Cancer |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C86803240 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9361952543258667 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[0].display_name | Biology |
| concepts[1].id | https://openalex.org/C126749454 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7980198860168457 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1348455 |
| concepts[1].display_name | Neural crest |
| concepts[2].id | https://openalex.org/C105702510 |
| concepts[2].level | 1 |
| concepts[2].score | 0.42481136322021484 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q514 |
| concepts[2].display_name | Anatomy |
| concepts[3].id | https://openalex.org/C169760540 |
| concepts[3].level | 1 |
| concepts[3].score | 0.3959445357322693 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[3].display_name | Neuroscience |
| concepts[4].id | https://openalex.org/C95444343 |
| concepts[4].level | 1 |
| concepts[4].score | 0.2564948499202728 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[4].display_name | Cell biology |
| concepts[5].id | https://openalex.org/C196843134 |
| concepts[5].level | 2 |
| concepts[5].score | 0.08633160591125488 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q33196 |
| concepts[5].display_name | Embryo |
| keywords[0].id | https://openalex.org/keywords/biology |
| keywords[0].score | 0.9361952543258667 |
| keywords[0].display_name | Biology |
| keywords[1].id | https://openalex.org/keywords/neural-crest |
| keywords[1].score | 0.7980198860168457 |
| keywords[1].display_name | Neural crest |
| keywords[2].id | https://openalex.org/keywords/anatomy |
| keywords[2].score | 0.42481136322021484 |
| keywords[2].display_name | Anatomy |
| keywords[3].id | https://openalex.org/keywords/neuroscience |
| keywords[3].score | 0.3959445357322693 |
| keywords[3].display_name | Neuroscience |
| keywords[4].id | https://openalex.org/keywords/cell-biology |
| keywords[4].score | 0.2564948499202728 |
| keywords[4].display_name | Cell biology |
| keywords[5].id | https://openalex.org/keywords/embryo |
| keywords[5].score | 0.08633160591125488 |
| keywords[5].display_name | Embryo |
| language | en |
| locations[0].id | doi:10.1002/cne.24801 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S4210186231 |
| locations[0].source.issn | 0021-9967, 1096-9861 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0021-9967 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | The Journal of Comparative Neurology |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_lineage_names | Wiley |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Comparative Neurology |
| locations[0].landing_page_url | https://doi.org/10.1002/cne.24801 |
| locations[1].id | pmid:31658363 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | The Journal of comparative neurology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/31658363 |
| locations[2].id | pmh:oai:HAL:hal-02332399v1 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306402512 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[2].source.host_organization | https://openalex.org/I1294671590 |
| locations[2].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[2].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Journal articles |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Journal of Comparative Neurology, In press, 528, pp.879. ⟨10.1002/cne.24801⟩ |
| locations[2].landing_page_url | https://hal.science/hal-02332399 |
| locations[3].id | pmh:oai:HAL:hal-04824220v1 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306402512 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[3].source.host_organization | https://openalex.org/I1294671590 |
| locations[3].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[3].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | info:eu-repo/semantics/article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | ISSN: 0021-9967 |
| locations[3].landing_page_url | https://hal.science/hal-04824220 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5001545754 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Andreia S. Margarido |
| authorships[0].countries | FR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516 |
| authorships[0].affiliations[0].raw_affiliation_string | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| authorships[0].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[0].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[0].institutions[0].country_code | FR |
| authorships[0].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[0].institutions[1].id | https://openalex.org/I154526488 |
| authorships[0].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[0].institutions[1].type | government |
| authorships[0].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[0].institutions[1].country_code | FR |
| authorships[0].institutions[1].display_name | Inserm |
| authorships[0].institutions[2].id | https://openalex.org/I4210086516 |
| authorships[0].institutions[2].ror | https://ror.org/003sscq03 |
| authorships[0].institutions[2].type | facility |
| authorships[0].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516, https://openalex.org/I4210096427 |
| authorships[0].institutions[2].country_code | FR |
| authorships[0].institutions[2].display_name | Physiologie et Médecine Expérimentale du Coeur et des Muscles |
| authorships[0].institutions[3].id | https://openalex.org/I19894307 |
| authorships[0].institutions[3].ror | https://ror.org/051escj72 |
| authorships[0].institutions[3].type | education |
| authorships[0].institutions[3].lineage | https://openalex.org/I19894307 |
| authorships[0].institutions[3].country_code | FR |
| authorships[0].institutions[3].display_name | Université de Montpellier |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Andreia S. Margarido |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| authorships[1].author.id | https://openalex.org/A5023815964 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Ludovic Le Guen |
| authorships[1].countries | FR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516 |
| authorships[1].affiliations[0].raw_affiliation_string | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| authorships[1].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[1].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[1].institutions[0].country_code | FR |
| authorships[1].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[1].institutions[1].id | https://openalex.org/I154526488 |
| authorships[1].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[1].institutions[1].type | government |
| authorships[1].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[1].institutions[1].country_code | FR |
| authorships[1].institutions[1].display_name | Inserm |
| authorships[1].institutions[2].id | https://openalex.org/I4210086516 |
| authorships[1].institutions[2].ror | https://ror.org/003sscq03 |
| authorships[1].institutions[2].type | facility |
| authorships[1].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516, https://openalex.org/I4210096427 |
| authorships[1].institutions[2].country_code | FR |
| authorships[1].institutions[2].display_name | Physiologie et Médecine Expérimentale du Coeur et des Muscles |
| authorships[1].institutions[3].id | https://openalex.org/I19894307 |
| authorships[1].institutions[3].ror | https://ror.org/051escj72 |
| authorships[1].institutions[3].type | education |
| authorships[1].institutions[3].lineage | https://openalex.org/I19894307 |
| authorships[1].institutions[3].country_code | FR |
| authorships[1].institutions[3].display_name | Université de Montpellier |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ludovic Le Guen |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| authorships[2].author.id | https://openalex.org/A5008905212 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-4247-0142 |
| authorships[2].author.display_name | Amandine Falco |
| authorships[2].countries | FR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516 |
| authorships[2].affiliations[0].raw_affiliation_string | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| authorships[2].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[2].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[2].institutions[0].country_code | FR |
| authorships[2].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[2].institutions[1].id | https://openalex.org/I154526488 |
| authorships[2].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[2].institutions[1].type | government |
| authorships[2].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[2].institutions[1].country_code | FR |
| authorships[2].institutions[1].display_name | Inserm |
| authorships[2].institutions[2].id | https://openalex.org/I4210086516 |
| authorships[2].institutions[2].ror | https://ror.org/003sscq03 |
| authorships[2].institutions[2].type | facility |
| authorships[2].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516, https://openalex.org/I4210096427 |
| authorships[2].institutions[2].country_code | FR |
| authorships[2].institutions[2].display_name | Physiologie et Médecine Expérimentale du Coeur et des Muscles |
| authorships[2].institutions[3].id | https://openalex.org/I19894307 |
| authorships[2].institutions[3].ror | https://ror.org/051escj72 |
| authorships[2].institutions[3].type | education |
| authorships[2].institutions[3].lineage | https://openalex.org/I19894307 |
| authorships[2].institutions[3].country_code | FR |
| authorships[2].institutions[3].display_name | Université de Montpellier |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Amandine Falco |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| authorships[3].author.id | https://openalex.org/A5014457057 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-8902-8274 |
| authorships[3].author.display_name | Sandrine Faure |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516 |
| authorships[3].affiliations[0].raw_affiliation_string | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| authorships[3].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[3].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[3].institutions[1].id | https://openalex.org/I154526488 |
| authorships[3].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[3].institutions[1].type | government |
| authorships[3].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Inserm |
| authorships[3].institutions[2].id | https://openalex.org/I4210086516 |
| authorships[3].institutions[2].ror | https://ror.org/003sscq03 |
| authorships[3].institutions[2].type | facility |
| authorships[3].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516, https://openalex.org/I4210096427 |
| authorships[3].institutions[2].country_code | FR |
| authorships[3].institutions[2].display_name | Physiologie et Médecine Expérimentale du Coeur et des Muscles |
| authorships[3].institutions[3].id | https://openalex.org/I19894307 |
| authorships[3].institutions[3].ror | https://ror.org/051escj72 |
| authorships[3].institutions[3].type | education |
| authorships[3].institutions[3].lineage | https://openalex.org/I19894307 |
| authorships[3].institutions[3].country_code | FR |
| authorships[3].institutions[3].display_name | Université de Montpellier |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Sandrine Faure |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| authorships[4].author.id | https://openalex.org/A5062697964 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-4388-6422 |
| authorships[4].author.display_name | Norbert Chauvet |
| authorships[4].countries | FR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516 |
| authorships[4].affiliations[0].raw_affiliation_string | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| authorships[4].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[4].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[4].institutions[0].country_code | FR |
| authorships[4].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[4].institutions[1].id | https://openalex.org/I154526488 |
| authorships[4].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[4].institutions[1].type | government |
| authorships[4].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[4].institutions[1].country_code | FR |
| authorships[4].institutions[1].display_name | Inserm |
| authorships[4].institutions[2].id | https://openalex.org/I4210086516 |
| authorships[4].institutions[2].ror | https://ror.org/003sscq03 |
| authorships[4].institutions[2].type | facility |
| authorships[4].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516, https://openalex.org/I4210096427 |
| authorships[4].institutions[2].country_code | FR |
| authorships[4].institutions[2].display_name | Physiologie et Médecine Expérimentale du Coeur et des Muscles |
| authorships[4].institutions[3].id | https://openalex.org/I19894307 |
| authorships[4].institutions[3].ror | https://ror.org/051escj72 |
| authorships[4].institutions[3].type | education |
| authorships[4].institutions[3].lineage | https://openalex.org/I19894307 |
| authorships[4].institutions[3].country_code | FR |
| authorships[4].institutions[3].display_name | Université de Montpellier |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Norbert Chauvet |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| authorships[5].author.id | https://openalex.org/A5058378827 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-9040-2481 |
| authorships[5].author.display_name | Pascal de Santa Barbara |
| authorships[5].countries | FR |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516 |
| authorships[5].affiliations[0].raw_affiliation_string | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| authorships[5].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[5].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[5].institutions[0].type | government |
| authorships[5].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[5].institutions[0].country_code | FR |
| authorships[5].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[5].institutions[1].id | https://openalex.org/I154526488 |
| authorships[5].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[5].institutions[1].type | government |
| authorships[5].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[5].institutions[1].country_code | FR |
| authorships[5].institutions[1].display_name | Inserm |
| authorships[5].institutions[2].id | https://openalex.org/I4210086516 |
| authorships[5].institutions[2].ror | https://ror.org/003sscq03 |
| authorships[5].institutions[2].type | facility |
| authorships[5].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I19894307, https://openalex.org/I4210086516, https://openalex.org/I4210096427 |
| authorships[5].institutions[2].country_code | FR |
| authorships[5].institutions[2].display_name | Physiologie et Médecine Expérimentale du Coeur et des Muscles |
| authorships[5].institutions[3].id | https://openalex.org/I19894307 |
| authorships[5].institutions[3].ror | https://ror.org/051escj72 |
| authorships[5].institutions[3].type | education |
| authorships[5].institutions[3].lineage | https://openalex.org/I19894307 |
| authorships[5].institutions[3].country_code | FR |
| authorships[5].institutions[3].display_name | Université de Montpellier |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | Pascal de Santa Barbara |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | PHYMEDEXP Université de Montpellier, INSERM, CNRS Montpellier France |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://hal.science/hal-02332399 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | PROX1 is a specific and dynamic marker of sacral neural crest cells in the chicken intestine |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12237 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9986000061035156 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2746 |
| primary_topic.subfield.display_name | Surgery |
| primary_topic.display_name | Congenital gastrointestinal and neural anomalies |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W2082860237, https://openalex.org/W2119695867, https://openalex.org/W2130076355, https://openalex.org/W1990804418, https://openalex.org/W1993764875, https://openalex.org/W2046158694, https://openalex.org/W2788277189, https://openalex.org/W2013243191, https://openalex.org/W1971568933 |
| cited_by_count | 5 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2021 |
| counts_by_year[2].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | pmh:oai:HAL:hal-02332399v1 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402512 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| best_oa_location.source.host_organization | https://openalex.org/I1294671590 |
| best_oa_location.source.host_organization_name | Centre National de la Recherche Scientifique |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1294671590 |
| best_oa_location.license | other-oa |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Journal articles |
| best_oa_location.license_id | https://openalex.org/licenses/other-oa |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Journal of Comparative Neurology, In press, 528, pp.879. ⟨10.1002/cne.24801⟩ |
| best_oa_location.landing_page_url | https://hal.science/hal-02332399 |
| primary_location.id | doi:10.1002/cne.24801 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S4210186231 |
| primary_location.source.issn | 0021-9967, 1096-9861 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0021-9967 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | The Journal of Comparative Neurology |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Comparative Neurology |
| primary_location.landing_page_url | https://doi.org/10.1002/cne.24801 |
| publication_date | 2019-10-28 |
| publication_year | 2019 |
| referenced_works | https://openalex.org/W1489850871, https://openalex.org/W2130583261, https://openalex.org/W2588444267, https://openalex.org/W2082664528, https://openalex.org/W2082073317, https://openalex.org/W2129631494, https://openalex.org/W2112691813, https://openalex.org/W2111524583, https://openalex.org/W2023718751, https://openalex.org/W1963969009, https://openalex.org/W1975774582, https://openalex.org/W1996600747, https://openalex.org/W1975477048, https://openalex.org/W2765346006, https://openalex.org/W2915554805, https://openalex.org/W2071621760, https://openalex.org/W2066490576, https://openalex.org/W6641984347, https://openalex.org/W1993000387, https://openalex.org/W2140034535, https://openalex.org/W2401967881, https://openalex.org/W2111501216, https://openalex.org/W2054712002, https://openalex.org/W2054593736, https://openalex.org/W2087014061, https://openalex.org/W1565566882, https://openalex.org/W2181892845, https://openalex.org/W1914096163, https://openalex.org/W2019930415, https://openalex.org/W1998148816, https://openalex.org/W2131738206, https://openalex.org/W2048100600, https://openalex.org/W2102812687, https://openalex.org/W2344651163, https://openalex.org/W2762174393, https://openalex.org/W2120779830, https://openalex.org/W2971671469, https://openalex.org/W1976554440, https://openalex.org/W2248228111, https://openalex.org/W2056969356, https://openalex.org/W2030866995, https://openalex.org/W2087772215, https://openalex.org/W2100939730, https://openalex.org/W1488041855, https://openalex.org/W2027734657, https://openalex.org/W2048787156, https://openalex.org/W1964409980, https://openalex.org/W2152179968, https://openalex.org/W2336196376, https://openalex.org/W1577577364, https://openalex.org/W2071059490, https://openalex.org/W2004364027, https://openalex.org/W1990117383, https://openalex.org/W2169593856, https://openalex.org/W1576809538, https://openalex.org/W1994638693, https://openalex.org/W2089348287, https://openalex.org/W3022530433, https://openalex.org/W4232557117, https://openalex.org/W2340586578 |
| referenced_works_count | 60 |
| abstract_inverted_index.1 | 110 |
| abstract_inverted_index.a | 7, 119, 126, 169 |
| abstract_inverted_index.In | 46 |
| abstract_inverted_index.an | 57 |
| abstract_inverted_index.as | 245 |
| abstract_inverted_index.at | 39 |
| abstract_inverted_index.in | 112, 128, 132, 136, 148, 151, 155, 183, 227 |
| abstract_inverted_index.is | 6, 118, 146, 204 |
| abstract_inverted_index.no | 94 |
| abstract_inverted_index.of | 11, 21, 42, 64, 86, 90, 107, 192, 220, 237 |
| abstract_inverted_index.to | 56, 68, 78, 82, 215, 233, 240 |
| abstract_inverted_index.we | 102, 142, 164, 180 |
| abstract_inverted_index.ENS | 25, 242 |
| abstract_inverted_index.NoR | 153, 177 |
| abstract_inverted_index.Our | 199 |
| abstract_inverted_index.PCR | 163 |
| abstract_inverted_index.The | 1 |
| abstract_inverted_index.and | 13, 30, 67, 80, 139, 154, 171, 231 |
| abstract_inverted_index.are | 36, 189 |
| abstract_inverted_index.gut | 229 |
| abstract_inverted_index.has | 98 |
| abstract_inverted_index.the | 18, 22, 40, 43, 69, 75, 83, 87, 91, 104, 113, 152, 156, 190, 193, 197, 205, 218, 221, 235 |
| abstract_inverted_index.(the | 61 |
| abstract_inverted_index.NoR. | 198 |
| abstract_inverted_index.This | 212 |
| abstract_inverted_index.been | 99 |
| abstract_inverted_index.cell | 129, 185, 225 |
| abstract_inverted_index.from | 28 |
| abstract_inverted_index.give | 54 |
| abstract_inverted_index.gut. | 92 |
| abstract_inverted_index.help | 214 |
| abstract_inverted_index.part | 89 |
| abstract_inverted_index.rise | 55 |
| abstract_inverted_index.role | 127, 219 |
| abstract_inverted_index.sNCC | 96 |
| abstract_inverted_index.situ | 137 |
| abstract_inverted_index.such | 244 |
| abstract_inverted_index.that | 16, 35, 124, 144, 166, 187, 202, 208 |
| abstract_inverted_index.type | 130 |
| abstract_inverted_index.vivo | 184 |
| abstract_inverted_index.(ENS) | 5 |
| abstract_inverted_index.Here, | 101 |
| abstract_inverted_index.Nerve | 63 |
| abstract_inverted_index.PROX1 | 117, 145, 167, 203 |
| abstract_inverted_index.Remak | 65 |
| abstract_inverted_index.Then, | 159 |
| abstract_inverted_index.Using | 135 |
| abstract_inverted_index.cells | 15, 26, 34, 51, 195 |
| abstract_inverted_index.chick | 115 |
| abstract_inverted_index.colon | 76 |
| abstract_inverted_index.crest | 33, 50, 224 |
| abstract_inverted_index.enter | 74 |
| abstract_inverted_index.first | 53, 206 |
| abstract_inverted_index.found | 165 |
| abstract_inverted_index.glial | 14 |
| abstract_inverted_index.might | 213 |
| abstract_inverted_index.plays | 125 |
| abstract_inverted_index.sNCCs | 73, 149, 188 |
| abstract_inverted_index.tube. | 45 |
| abstract_inverted_index.using | 160, 182 |
| abstract_inverted_index.vagal | 29 |
| abstract_inverted_index.Later, | 72 |
| abstract_inverted_index.[NoR]) | 66 |
| abstract_inverted_index.better | 216 |
| abstract_inverted_index.birds, | 47 |
| abstract_inverted_index.border | 41 |
| abstract_inverted_index.caudal | 88 |
| abstract_inverted_index.colon. | 116 |
| abstract_inverted_index.distal | 228 |
| abstract_inverted_index.domain | 121 |
| abstract_inverted_index.during | 176 |
| abstract_inverted_index.factor | 123 |
| abstract_inverted_index.highly | 172 |
| abstract_inverted_index.linked | 239 |
| abstract_inverted_index.marker | 97, 207 |
| abstract_inverted_index.neural | 32, 44, 49, 223 |
| abstract_inverted_index.pelvic | 70, 157 |
| abstract_inverted_index.report | 103 |
| abstract_inverted_index.sNCCs. | 211 |
| abstract_inverted_index.sacral | 31, 48 |
| abstract_inverted_index.showed | 143 |
| abstract_inverted_index.source | 191 |
| abstract_inverted_index.strong | 170 |
| abstract_inverted_index.system | 4 |
| abstract_inverted_index.tract. | 24 |
| abstract_inverted_index.within | 196 |
| abstract_inverted_index.(PROX1) | 111 |
| abstract_inverted_index.(sNCCs) | 52 |
| abstract_inverted_index.complex | 8 |
| abstract_inverted_index.dynamic | 173 |
| abstract_inverted_index.ensures | 17 |
| abstract_inverted_index.enteric | 2 |
| abstract_inverted_index.improve | 234 |
| abstract_inverted_index.located | 38 |
| abstract_inverted_index.nervous | 3 |
| abstract_inverted_index.network | 9 |
| abstract_inverted_index.neurons | 12 |
| abstract_inverted_index.pattern | 106, 175 |
| abstract_inverted_index.plexus. | 71, 158 |
| abstract_inverted_index.results | 200 |
| abstract_inverted_index.various | 133 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.However, | 93 |
| abstract_inverted_index.colonize | 79 |
| abstract_inverted_index.disease. | 247 |
| abstract_inverted_index.diseases | 238 |
| abstract_inverted_index.displays | 168 |
| abstract_inverted_index.homeobox | 109, 120 |
| abstract_inverted_index.identify | 217 |
| abstract_inverted_index.indicate | 201 |
| abstract_inverted_index.specific | 95 |
| abstract_inverted_index.tissues. | 134 |
| abstract_inverted_index.tracing, | 186 |
| abstract_inverted_index.Moreover, | 179 |
| abstract_inverted_index.diagnosis | 236 |
| abstract_inverted_index.different | 222 |
| abstract_inverted_index.expressed | 147 |
| abstract_inverted_index.initially | 37 |
| abstract_inverted_index.intrinsic | 19, 84 |
| abstract_inverted_index.localized | 150 |
| abstract_inverted_index.originate | 27 |
| abstract_inverted_index.structure | 60 |
| abstract_inverted_index.contribute | 81 |
| abstract_inverted_index.described. | 100 |
| abstract_inverted_index.developing | 114 |
| abstract_inverted_index.expression | 105, 174 |
| abstract_inverted_index.extramural | 58 |
| abstract_inverted_index.formation, | 243 |
| abstract_inverted_index.identifies | 210 |
| abstract_inverted_index.incomplete | 241 |
| abstract_inverted_index.mesenchyme | 77 |
| abstract_inverted_index.constituted | 10 |
| abstract_inverted_index.innervation | 20, 85 |
| abstract_inverted_index.populations | 226 |
| abstract_inverted_index.real‐time | 161 |
| abstract_inverted_index.so‐called | 62 |
| abstract_inverted_index.techniques, | 141 |
| abstract_inverted_index.consequently | 232 |
| abstract_inverted_index.demonstrated | 181 |
| abstract_inverted_index.development. | 178 |
| abstract_inverted_index.ganglionated | 59 |
| abstract_inverted_index.innervation, | 230 |
| abstract_inverted_index.quantitative | 162 |
| abstract_inverted_index.specifically | 209 |
| abstract_inverted_index.hybridization | 138 |
| abstract_inverted_index.specification | 131 |
| abstract_inverted_index.transcription | 122 |
| abstract_inverted_index.Hirschsprung's | 246 |
| abstract_inverted_index.PROX1‐positive | 194 |
| abstract_inverted_index.gastrointestinal | 23 |
| abstract_inverted_index.immunofluorescence | 140 |
| abstract_inverted_index.prospero‐related | 108 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| citation_normalized_percentile.value | 0.59873125 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |