Pseudomonas aeruginosa quorum-sensing response in the absence of functional LasR and LasI proteins: the case of strain 148, a virulent dolphin isolate Article Swipe
Estefanía Morales-Ruiz
,
Abigail González‐Valdez
,
Luis Servı́n-González
,
Gloria Soberón‐Chávez
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1093/femsle/fnx119
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1093/femsle/fnx119
Pseudomonas aeruginosa is an opportunistic pathogen that presents a complex regulatory network called 'quorum-sensing', which is responsible for the transcription of genes coding for several traits implicated in its pathogenicity. Strain 148 is a dolphin isolate that has been shown to produce quorum-sensing-regulated virulence traits and to be virulent in a mouse model, despite the fact that it contains a 20-kbp deletion that eliminates from the chromosome the lasR gene and the lasI promoter. LasR is a key quorum-sensing transcriptional regulator that, when coupled with the autoinducer 3-oxo-dodecanoyl homoserine lactone (3O-C12-HSL) produced by LasI, activates transcription of genes coding for some virulence-associated traits such as elastase, lasI, rhlI and rhlR. RhlR is also a key quorum-sensing transcriptional regulator that, when interacting with the autoinducer butanoyl homoserine lactone (C4-HSL) that is produced by the synthase RhlI, activates the genes involved in the synthesis of some virulence-associated traits, as rhamnolipids and pyocyanin. We describe that in P. aeruginosa 148, the LasR/3O-C12-HSL-independent rhlR transcriptional activation is due to the release of the negative effect of Vfr (a CRP-ortholog) caused by the insertion of an IS element in vfr, and that rhlI transcription is driven from the rhlR promoter, forming the rhlR-I operon.
Related Topics
Concepts
Quorum sensing
Virulence
Homoserine
Pseudomonas aeruginosa
Pyocyanin
Autoinducer
Biology
Operon
Gene
Genetics
Transcription (linguistics)
Microbiology
Transcriptional regulation
Regulator
Transcription factor
Bacteria
Escherichia coli
Philosophy
Linguistics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/femsle/fnx119
- https://academic.oup.com/femsle/article-pdf/364/12/fnx119/23929453/fnx119.pdf
- OA Status
- bronze
- Cited By
- 30
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2624295660
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2624295660Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/femsle/fnx119Digital Object Identifier
- Title
-
Pseudomonas aeruginosa quorum-sensing response in the absence of functional LasR and LasI proteins: the case of strain 148, a virulent dolphin isolateWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-06-01Full publication date if available
- Authors
-
Estefanía Morales-Ruiz, Abigail González‐Valdez, Luis Servı́n-González, Gloria Soberón‐ChávezList of authors in order
- Landing page
-
https://doi.org/10.1093/femsle/fnx119Publisher landing page
- PDF URL
-
https://academic.oup.com/femsle/article-pdf/364/12/fnx119/23929453/fnx119.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/femsle/article-pdf/364/12/fnx119/23929453/fnx119.pdfDirect OA link when available
- Concepts
-
Quorum sensing, Virulence, Homoserine, Pseudomonas aeruginosa, Pyocyanin, Autoinducer, Biology, Operon, Gene, Genetics, Transcription (linguistics), Microbiology, Transcriptional regulation, Regulator, Transcription factor, Bacteria, Escherichia coli, Philosophy, LinguisticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 4, 2023: 1, 2022: 3, 2021: 5, 2020: 8Per-year citation counts (last 5 years)
- References (count)
-
54Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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