Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks Article Swipe
Quan Jiang
,
Ling-Xiao Shao
,
Shenqin Yao
,
Neil K. Savalia
,
Annie-Kim Gilbert
,
Pasha A. Davoudian
,
Jack D. Nothnagel
,
Guilian Tian
,
Tin Shing Hung
,
H. M. Lai
,
Kevin T. Beier
,
Hongkui Zeng
,
Alex C. Kwan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.06.668927
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.08.06.668927
SUMMARY Psilocybin holds promise as a treatment for mental illnesses. One dose of psilocybin induces structural remodeling of dendritic spines in the medial frontal cortex in mice. The dendritic spines would be innervated by presynaptic neurons, but the sources of these inputs have not been identified. Here, using monosynaptic rabies tracing, we map the brain-wide distribution of inputs to frontal cortical pyramidal neurons. We discover that psilocybin’s effect on connectivity is network-specific: strengthening the routing of inputs from perceptual and medial regions (homolog of default mode network) to subcortical targets, while weakening inputs that are part of cortico-cortical recurrent loops. The pattern of synaptic reorganization depends on the drug-evoked spiking activity, because silencing a presynaptic region during psilocybin administration disrupts the rewiring. Collectively, the results reveal the impact of psilocybin on the connectivity of large-scale cortical networks and demonstrate neural activity modulation as an approach to sculpt the psychedelic-evoked neural plasticity.
Related Topics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.08.06.668927
- https://www.biorxiv.org/content/biorxiv/early/2025/08/06/2025.08.06.668927.full.pdf
- OA Status
- green
- References
- 83
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413121052
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4413121052Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2025.08.06.668927Digital Object Identifier
- Title
-
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networksWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-08-06Full publication date if available
- Authors
-
Quan Jiang, Ling-Xiao Shao, Shenqin Yao, Neil K. Savalia, Annie-Kim Gilbert, Pasha A. Davoudian, Jack D. Nothnagel, Guilian Tian, Tin Shing Hung, H. M. Lai, Kevin T. Beier, Hongkui Zeng, Alex C. KwanList of authors in order
- Landing page
-
https://doi.org/10.1101/2025.08.06.668927Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2025/08/06/2025.08.06.668927.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2025/08/06/2025.08.06.668927.full.pdfDirect OA link when available
- Concepts
-
Psilocybin, Neuroscience, Neuroplasticity, Psychology, Biology, Hallucinogen, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
83Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4413121052 |
|---|---|
| doi | https://doi.org/10.1101/2025.08.06.668927 |
| ids.doi | https://doi.org/10.1101/2025.08.06.668927 |
| ids.openalex | https://openalex.org/W4413121052 |
| fwci | 0.0 |
| type | article |
| title | Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T12553 |
| topics[0].field.id | https://openalex.org/fields/32 |
| topics[0].field.display_name | Psychology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/2 |
| topics[0].domain.display_name | Social Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/3203 |
| topics[0].subfield.display_name | Clinical Psychology |
| topics[0].display_name | Psychedelics and Drug Studies |
| topics[1].id | https://openalex.org/T10056 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9817000031471252 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2804 |
| topics[1].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[1].display_name | Neurotransmitter Receptor Influence on Behavior |
| topics[2].id | https://openalex.org/T13124 |
| topics[2].field.id | https://openalex.org/fields/16 |
| topics[2].field.display_name | Chemistry |
| topics[2].score | 0.9728000164031982 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1605 |
| topics[2].subfield.display_name | Organic Chemistry |
| topics[2].display_name | Chemical synthesis and alkaloids |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2776502132 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8517626523971558 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q208118 |
| concepts[0].display_name | Psilocybin |
| concepts[1].id | https://openalex.org/C169760540 |
| concepts[1].level | 1 |
| concepts[1].score | 0.8141372203826904 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[1].display_name | Neuroscience |
| concepts[2].id | https://openalex.org/C47611674 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5212669968605042 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q849491 |
| concepts[2].display_name | Neuroplasticity |
| concepts[3].id | https://openalex.org/C15744967 |
| concepts[3].level | 0 |
| concepts[3].score | 0.404108464717865 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[3].display_name | Psychology |
| concepts[4].id | https://openalex.org/C86803240 |
| concepts[4].level | 0 |
| concepts[4].score | 0.3262999653816223 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[4].display_name | Biology |
| concepts[5].id | https://openalex.org/C124315065 |
| concepts[5].level | 2 |
| concepts[5].score | 0.27794530987739563 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q194270 |
| concepts[5].display_name | Hallucinogen |
| concepts[6].id | https://openalex.org/C118552586 |
| concepts[6].level | 1 |
| concepts[6].score | 0.0 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7867 |
| concepts[6].display_name | Psychiatry |
| keywords[0].id | https://openalex.org/keywords/psilocybin |
| keywords[0].score | 0.8517626523971558 |
| keywords[0].display_name | Psilocybin |
| keywords[1].id | https://openalex.org/keywords/neuroscience |
| keywords[1].score | 0.8141372203826904 |
| keywords[1].display_name | Neuroscience |
| keywords[2].id | https://openalex.org/keywords/neuroplasticity |
| keywords[2].score | 0.5212669968605042 |
| keywords[2].display_name | Neuroplasticity |
| keywords[3].id | https://openalex.org/keywords/psychology |
| keywords[3].score | 0.404108464717865 |
| keywords[3].display_name | Psychology |
| keywords[4].id | https://openalex.org/keywords/biology |
| keywords[4].score | 0.3262999653816223 |
| keywords[4].display_name | Biology |
| keywords[5].id | https://openalex.org/keywords/hallucinogen |
| keywords[5].score | 0.27794530987739563 |
| keywords[5].display_name | Hallucinogen |
| language | en |
| locations[0].id | doi:10.1101/2025.08.06.668927 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2025/08/06/2025.08.06.668927.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2025.08.06.668927 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5014357436 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-8201-6417 |
| authorships[0].author.display_name | Quan Jiang |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I205783295 |
| authorships[0].affiliations[0].raw_affiliation_string | Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[0].institutions[0].id | https://openalex.org/I205783295 |
| authorships[0].institutions[0].ror | https://ror.org/05bnh6r87 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I205783295 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Cornell University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Quan Jiang |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[1].author.id | https://openalex.org/A5018142239 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Ling-Xiao Shao |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I205783295 |
| authorships[1].affiliations[0].raw_affiliation_string | Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[1].institutions[0].id | https://openalex.org/I205783295 |
| authorships[1].institutions[0].ror | https://ror.org/05bnh6r87 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I205783295 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Cornell University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Lingxiao Shao |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[2].author.id | https://openalex.org/A5084565960 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-2992-4752 |
| authorships[2].author.display_name | Shenqin Yao |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1314596251, https://openalex.org/I4210140341 |
| authorships[2].affiliations[0].raw_affiliation_string | Allen Institute for Brain Science, Seattle, WA, 98109, USA |
| authorships[2].institutions[0].id | https://openalex.org/I4210140341 |
| authorships[2].institutions[0].ror | https://ror.org/03cpe7c52 |
| authorships[2].institutions[0].type | nonprofit |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210140341 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Allen Institute |
| authorships[2].institutions[1].id | https://openalex.org/I1314596251 |
| authorships[2].institutions[1].ror | https://ror.org/00dcv1019 |
| authorships[2].institutions[1].type | facility |
| authorships[2].institutions[1].lineage | https://openalex.org/I1314596251, https://openalex.org/I4210140341 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | Allen Institute for Brain Science |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Shenqin Yao |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Allen Institute for Brain Science, Seattle, WA, 98109, USA |
| authorships[3].author.id | https://openalex.org/A5081566415 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-2262-4466 |
| authorships[3].author.display_name | Neil K. Savalia |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I205783295 |
| authorships[3].affiliations[0].raw_affiliation_string | Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I32971472 |
| authorships[3].affiliations[1].raw_affiliation_string | Medical Scientist Training Program, Yale University School of Medicine, New Haven, CT, 06511, USA |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I32971472 |
| authorships[3].affiliations[2].raw_affiliation_string | Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, 06511, USA |
| authorships[3].institutions[0].id | https://openalex.org/I205783295 |
| authorships[3].institutions[0].ror | https://ror.org/05bnh6r87 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I205783295 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Cornell University |
| authorships[3].institutions[1].id | https://openalex.org/I32971472 |
| authorships[3].institutions[1].ror | https://ror.org/03v76x132 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I32971472 |
| authorships[3].institutions[1].country_code | US |
| authorships[3].institutions[1].display_name | Yale University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Neil K. Savalia |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, 06511, USA, Medical Scientist Training Program, Yale University School of Medicine, New Haven, CT, 06511, USA, Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[4].author.id | https://openalex.org/A5041826945 |
| authorships[4].author.orcid | https://orcid.org/0009-0008-5728-2674 |
| authorships[4].author.display_name | Annie-Kim Gilbert |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I205783295 |
| authorships[4].affiliations[0].raw_affiliation_string | Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[4].institutions[0].id | https://openalex.org/I205783295 |
| authorships[4].institutions[0].ror | https://ror.org/05bnh6r87 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I205783295 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Cornell University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Amelia D. Gilbert |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[5].author.id | https://openalex.org/A5066262562 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-5096-7610 |
| authorships[5].author.display_name | Pasha A. Davoudian |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I32971472 |
| authorships[5].affiliations[0].raw_affiliation_string | Medical Scientist Training Program, Yale University School of Medicine, New Haven, CT, 06511, USA |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I205783295 |
| authorships[5].affiliations[1].raw_affiliation_string | Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[5].affiliations[2].institution_ids | https://openalex.org/I32971472 |
| authorships[5].affiliations[2].raw_affiliation_string | Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, 06511, USA |
| authorships[5].institutions[0].id | https://openalex.org/I205783295 |
| authorships[5].institutions[0].ror | https://ror.org/05bnh6r87 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I205783295 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Cornell University |
| authorships[5].institutions[1].id | https://openalex.org/I32971472 |
| authorships[5].institutions[1].ror | https://ror.org/03v76x132 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I32971472 |
| authorships[5].institutions[1].country_code | US |
| authorships[5].institutions[1].display_name | Yale University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Pasha A. Davoudian |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, 06511, USA, Medical Scientist Training Program, Yale University School of Medicine, New Haven, CT, 06511, USA, Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[6].author.id | https://openalex.org/A5114504919 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Jack D. Nothnagel |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I205783295 |
| authorships[6].affiliations[0].raw_affiliation_string | Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[6].institutions[0].id | https://openalex.org/I205783295 |
| authorships[6].institutions[0].ror | https://ror.org/05bnh6r87 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I205783295 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Cornell University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Jack D. Nothnagel |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[7].author.id | https://openalex.org/A5109899912 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Guilian Tian |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I204250578 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, 92697, USA |
| authorships[7].institutions[0].id | https://openalex.org/I204250578 |
| authorships[7].institutions[0].ror | https://ror.org/04gyf1771 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I204250578 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of California, Irvine |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Guilian Tian |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, 92697, USA |
| authorships[8].author.id | https://openalex.org/A5001774846 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-5557-1749 |
| authorships[8].author.display_name | Tin Shing Hung |
| authorships[8].countries | HK |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I177725633 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China |
| authorships[8].institutions[0].id | https://openalex.org/I177725633 |
| authorships[8].institutions[0].ror | https://ror.org/00t33hh48 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I177725633 |
| authorships[8].institutions[0].country_code | HK |
| authorships[8].institutions[0].display_name | Chinese University of Hong Kong |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Tin Shing Hung |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China |
| authorships[9].author.id | https://openalex.org/A5068995743 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-5150-7918 |
| authorships[9].author.display_name | H. M. Lai |
| authorships[9].countries | HK |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I177725633 |
| authorships[9].affiliations[0].raw_affiliation_string | Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I177725633 |
| authorships[9].affiliations[1].raw_affiliation_string | Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China |
| authorships[9].affiliations[2].institution_ids | https://openalex.org/I177725633 |
| authorships[9].affiliations[2].raw_affiliation_string | Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China |
| authorships[9].institutions[0].id | https://openalex.org/I177725633 |
| authorships[9].institutions[0].ror | https://ror.org/00t33hh48 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I177725633 |
| authorships[9].institutions[0].country_code | HK |
| authorships[9].institutions[0].display_name | Chinese University of Hong Kong |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Hei-Ming Lai |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China |
| authorships[10].author.id | https://openalex.org/A5073712778 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-4934-1338 |
| authorships[10].author.display_name | Kevin T. Beier |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I204250578 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, 92697, USA |
| authorships[10].institutions[0].id | https://openalex.org/I204250578 |
| authorships[10].institutions[0].ror | https://ror.org/04gyf1771 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I204250578 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | University of California, Irvine |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Kevin T. Beier |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, 92697, USA |
| authorships[11].author.id | https://openalex.org/A5010189175 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-0326-5878 |
| authorships[11].author.display_name | Hongkui Zeng |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I1314596251, https://openalex.org/I4210140341 |
| authorships[11].affiliations[0].raw_affiliation_string | Allen Institute for Brain Science, Seattle, WA, 98109, USA |
| authorships[11].institutions[0].id | https://openalex.org/I4210140341 |
| authorships[11].institutions[0].ror | https://ror.org/03cpe7c52 |
| authorships[11].institutions[0].type | nonprofit |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210140341 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | Allen Institute |
| authorships[11].institutions[1].id | https://openalex.org/I1314596251 |
| authorships[11].institutions[1].ror | https://ror.org/00dcv1019 |
| authorships[11].institutions[1].type | facility |
| authorships[11].institutions[1].lineage | https://openalex.org/I1314596251, https://openalex.org/I4210140341 |
| authorships[11].institutions[1].country_code | US |
| authorships[11].institutions[1].display_name | Allen Institute for Brain Science |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Hongkui Zeng |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Allen Institute for Brain Science, Seattle, WA, 98109, USA |
| authorships[12].author.id | https://openalex.org/A5014605321 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-2169-1667 |
| authorships[12].author.display_name | Alex C. Kwan |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I205783295, https://openalex.org/I4387153466 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Psychiatry, Weill Cornell Medicine, New York, NY, 10065, USA |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I205783295 |
| authorships[12].affiliations[1].raw_affiliation_string | Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| authorships[12].institutions[0].id | https://openalex.org/I205783295 |
| authorships[12].institutions[0].ror | https://ror.org/05bnh6r87 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I205783295 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Cornell University |
| authorships[12].institutions[1].id | https://openalex.org/I4387153466 |
| authorships[12].institutions[1].ror | https://ror.org/02r109517 |
| authorships[12].institutions[1].type | education |
| authorships[12].institutions[1].lineage | https://openalex.org/I205783295, https://openalex.org/I4387153466 |
| authorships[12].institutions[1].country_code | US |
| authorships[12].institutions[1].display_name | Weill Cornell Medicine |
| authorships[12].author_position | last |
| authorships[12].raw_author_name | Alex C. Kwan |
| authorships[12].is_corresponding | True |
| authorships[12].raw_affiliation_strings | Department of Psychiatry, Weill Cornell Medicine, New York, NY, 10065, USA, Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 4853, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2025/08/06/2025.08.06.668927.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12553 |
| primary_topic.field.id | https://openalex.org/fields/32 |
| primary_topic.field.display_name | Psychology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/2 |
| primary_topic.domain.display_name | Social Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/3203 |
| primary_topic.subfield.display_name | Clinical Psychology |
| primary_topic.display_name | Psychedelics and Drug Studies |
| related_works | https://openalex.org/W2748952813, https://openalex.org/W4391375266, https://openalex.org/W4312534256, https://openalex.org/W2072670605, https://openalex.org/W108080335, https://openalex.org/W2154105276, https://openalex.org/W4384835068, https://openalex.org/W4405029114, https://openalex.org/W3161556967, https://openalex.org/W4306177051 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2025.08.06.668927 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2025/08/06/2025.08.06.668927.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2025.08.06.668927 |
| primary_location.id | doi:10.1101/2025.08.06.668927 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2025/08/06/2025.08.06.668927.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2025.08.06.668927 |
| publication_date | 2025-08-06 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4211211437, https://openalex.org/W4220950644, https://openalex.org/W4308146982, https://openalex.org/W3156937150, https://openalex.org/W4386305655, https://openalex.org/W3096208965, https://openalex.org/W4313530670, https://openalex.org/W4292937262, https://openalex.org/W4307167512, https://openalex.org/W1998628114, https://openalex.org/W2933363539, https://openalex.org/W2089351762, https://openalex.org/W2308910221, https://openalex.org/W2935995671, https://openalex.org/W3179469168, https://openalex.org/W4362596352, https://openalex.org/W4311205265, https://openalex.org/W1964049834, https://openalex.org/W3159995594, https://openalex.org/W2921327779, https://openalex.org/W792393746, https://openalex.org/W4312192969, https://openalex.org/W2000816595, https://openalex.org/W2256675298, https://openalex.org/W3202866474, https://openalex.org/W2259444337, https://openalex.org/W4315620578, https://openalex.org/W2804230025, https://openalex.org/W2032996762, https://openalex.org/W4409147414, https://openalex.org/W3021105102, https://openalex.org/W2195364602, https://openalex.org/W4396227265, https://openalex.org/W4322771665, https://openalex.org/W4317802101, https://openalex.org/W2991212305, https://openalex.org/W2081432059, https://openalex.org/W1975389666, https://openalex.org/W2123491442, https://openalex.org/W2952817492, https://openalex.org/W3113989724, https://openalex.org/W4407396574, https://openalex.org/W2508528270, https://openalex.org/W2015376003, https://openalex.org/W3112749784, https://openalex.org/W2217108923, https://openalex.org/W2999279320, https://openalex.org/W2026832357, https://openalex.org/W4400729513, https://openalex.org/W3087469893, https://openalex.org/W4361300672, https://openalex.org/W1966403223, https://openalex.org/W3038591947, https://openalex.org/W4221083769, https://openalex.org/W3193577626, https://openalex.org/W2122427440, https://openalex.org/W2023394643, https://openalex.org/W1999831792, https://openalex.org/W3205085416, https://openalex.org/W4315620747, https://openalex.org/W975385166, https://openalex.org/W4403136437, https://openalex.org/W4294884857, https://openalex.org/W2754799005, https://openalex.org/W2800617744, https://openalex.org/W4404469548, https://openalex.org/W3112535936, https://openalex.org/W3164900028, https://openalex.org/W1903029394, https://openalex.org/W2194775991, https://openalex.org/W2004764691, https://openalex.org/W3104213443, https://openalex.org/W3142226569, https://openalex.org/W4313704034, https://openalex.org/W2038573700, https://openalex.org/W2166199673, https://openalex.org/W2898002359, https://openalex.org/W3138257762, https://openalex.org/W2991741056, https://openalex.org/W3080801996, https://openalex.org/W2947461179, https://openalex.org/W2975634117, https://openalex.org/W4389670555 |
| referenced_works_count | 83 |
| abstract_inverted_index.a | 5, 113 |
| abstract_inverted_index.We | 63 |
| abstract_inverted_index.an | 143 |
| abstract_inverted_index.as | 4, 142 |
| abstract_inverted_index.be | 31 |
| abstract_inverted_index.by | 33 |
| abstract_inverted_index.in | 20, 25 |
| abstract_inverted_index.is | 70 |
| abstract_inverted_index.of | 12, 17, 39, 56, 75, 83, 96, 102, 128, 133 |
| abstract_inverted_index.on | 68, 106, 130 |
| abstract_inverted_index.to | 58, 87, 145 |
| abstract_inverted_index.we | 51 |
| abstract_inverted_index.One | 10 |
| abstract_inverted_index.The | 27, 100 |
| abstract_inverted_index.and | 79, 137 |
| abstract_inverted_index.are | 94 |
| abstract_inverted_index.but | 36 |
| abstract_inverted_index.for | 7 |
| abstract_inverted_index.map | 52 |
| abstract_inverted_index.not | 43 |
| abstract_inverted_index.the | 21, 37, 53, 73, 107, 120, 123, 126, 131, 147 |
| abstract_inverted_index.been | 44 |
| abstract_inverted_index.dose | 11 |
| abstract_inverted_index.from | 77 |
| abstract_inverted_index.have | 42 |
| abstract_inverted_index.mode | 85 |
| abstract_inverted_index.part | 95 |
| abstract_inverted_index.that | 65, 93 |
| abstract_inverted_index.Here, | 46 |
| abstract_inverted_index.holds | 2 |
| abstract_inverted_index.mice. | 26 |
| abstract_inverted_index.these | 40 |
| abstract_inverted_index.using | 47 |
| abstract_inverted_index.while | 90 |
| abstract_inverted_index.would | 30 |
| abstract_inverted_index.cortex | 24 |
| abstract_inverted_index.during | 116 |
| abstract_inverted_index.effect | 67 |
| abstract_inverted_index.impact | 127 |
| abstract_inverted_index.inputs | 41, 57, 76, 92 |
| abstract_inverted_index.loops. | 99 |
| abstract_inverted_index.medial | 22, 80 |
| abstract_inverted_index.mental | 8 |
| abstract_inverted_index.neural | 139, 149 |
| abstract_inverted_index.rabies | 49 |
| abstract_inverted_index.region | 115 |
| abstract_inverted_index.reveal | 125 |
| abstract_inverted_index.sculpt | 146 |
| abstract_inverted_index.spines | 19, 29 |
| abstract_inverted_index.SUMMARY | 0 |
| abstract_inverted_index.because | 111 |
| abstract_inverted_index.default | 84 |
| abstract_inverted_index.depends | 105 |
| abstract_inverted_index.frontal | 23, 59 |
| abstract_inverted_index.induces | 14 |
| abstract_inverted_index.pattern | 101 |
| abstract_inverted_index.promise | 3 |
| abstract_inverted_index.regions | 81 |
| abstract_inverted_index.results | 124 |
| abstract_inverted_index.routing | 74 |
| abstract_inverted_index.sources | 38 |
| abstract_inverted_index.spiking | 109 |
| abstract_inverted_index.(homolog | 82 |
| abstract_inverted_index.activity | 140 |
| abstract_inverted_index.approach | 144 |
| abstract_inverted_index.cortical | 60, 135 |
| abstract_inverted_index.discover | 64 |
| abstract_inverted_index.disrupts | 119 |
| abstract_inverted_index.network) | 86 |
| abstract_inverted_index.networks | 136 |
| abstract_inverted_index.neurons, | 35 |
| abstract_inverted_index.neurons. | 62 |
| abstract_inverted_index.synaptic | 103 |
| abstract_inverted_index.targets, | 89 |
| abstract_inverted_index.tracing, | 50 |
| abstract_inverted_index.activity, | 110 |
| abstract_inverted_index.dendritic | 18, 28 |
| abstract_inverted_index.pyramidal | 61 |
| abstract_inverted_index.recurrent | 98 |
| abstract_inverted_index.rewiring. | 121 |
| abstract_inverted_index.silencing | 112 |
| abstract_inverted_index.treatment | 6 |
| abstract_inverted_index.weakening | 91 |
| abstract_inverted_index.Psilocybin | 1 |
| abstract_inverted_index.brain-wide | 54 |
| abstract_inverted_index.illnesses. | 9 |
| abstract_inverted_index.innervated | 32 |
| abstract_inverted_index.modulation | 141 |
| abstract_inverted_index.perceptual | 78 |
| abstract_inverted_index.psilocybin | 13, 117, 129 |
| abstract_inverted_index.remodeling | 16 |
| abstract_inverted_index.structural | 15 |
| abstract_inverted_index.demonstrate | 138 |
| abstract_inverted_index.drug-evoked | 108 |
| abstract_inverted_index.identified. | 45 |
| abstract_inverted_index.large-scale | 134 |
| abstract_inverted_index.plasticity. | 150 |
| abstract_inverted_index.presynaptic | 34, 114 |
| abstract_inverted_index.subcortical | 88 |
| abstract_inverted_index.connectivity | 69, 132 |
| abstract_inverted_index.distribution | 55 |
| abstract_inverted_index.monosynaptic | 48 |
| abstract_inverted_index.Collectively, | 122 |
| abstract_inverted_index.strengthening | 72 |
| abstract_inverted_index.administration | 118 |
| abstract_inverted_index.psilocybin’s | 66 |
| abstract_inverted_index.reorganization | 104 |
| abstract_inverted_index.cortico-cortical | 97 |
| abstract_inverted_index.network-specific: | 71 |
| abstract_inverted_index.psychedelic-evoked | 148 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5014605321 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I205783295, https://openalex.org/I4387153466 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.44107234 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |