Pulmonary Langerhans cell histiocytosis diagnosed using transbronchial lung cryobiopsy: A case report Article Swipe

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Medicine Langerhans cell histiocytosis Bronchoalveolar lavage Lung Radiology Pathological Lung biopsy Biopsy Bronchoscopy Pathology Internal medicine Disease

Keisuke Mine , Noriho Sakamoto , Mutsumi Ozasa , Shin Tsutsui , Ritsuko Miyashita , Takatomo Tokito , Daisuke Okuno , Hirokazu Yura , Takashi Kido , Hiroshi Ishimoto , Shinnosuke Takemoto , Takahiro Takazono , Yasushi Obase , Yuji Ishimatsu , Junya Fukuoka , Hiroshi Mukae ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1016/j.rmcr.2023.101928 · OA: W4387541701

A 63-year-old Japanese woman with multiple cysts in both lungs on chest computed tomography (CT) was referred to our hospital after a thorough examination, including a transbronchial lung biopsy (TBLB), failed to provide a diagnosis. Based on the findings on chest CT and pathological examination of the bronchoalveolar lavage fluid and transbronchial lung cryobiopsy (TBLC) specimen, the patient was diagnosed with pulmonary Langerhans cell histiocytosis (PLCH). TBLC may replace TBLB as the main diagnostic technique for PLCH, although further studies are required to determine the usefulness of TBLC for the diagnosis of PLCH.