Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1 Article Swipe
Michala G. Rolver
,
Line O. Elingaard-Larsen
,
Anne Poder Andersen
,
Laurent Counillon
,
Stine F. Pedersen
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-020-62430-z
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-020-62430-z
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-020-62430-z
- https://www.nature.com/articles/s41598-020-62430-z.pdf
- OA Status
- gold
- Cited By
- 54
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3014971593
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3014971593Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-020-62430-zDigital Object Identifier
- Title
-
Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-04-02Full publication date if available
- Authors
-
Michala G. Rolver, Line O. Elingaard-Larsen, Anne Poder Andersen, Laurent Counillon, Stine F. PedersenList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-020-62430-zPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s41598-020-62430-z.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41598-020-62430-z.pdfDirect OA link when available
- Concepts
-
Amiloride, Viability assay, Sodium–hydrogen antiporter, Chemistry, Programmed cell death, Cell growth, Cancer cell, Cancer research, Pharmacology, Apoptosis, Cancer, Biology, Biochemistry, Medicine, Internal medicine, Sodium, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
54Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 13, 2023: 9, 2022: 14, 2021: 14Per-year citation counts (last 5 years)
- References (count)
-
61Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3014971593 |
|---|---|
| doi | https://doi.org/10.1038/s41598-020-62430-z |
| ids.doi | https://doi.org/10.1038/s41598-020-62430-z |
| ids.mag | 3014971593 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/32242030 |
| ids.openalex | https://openalex.org/W3014971593 |
| fwci | 3.80355195 |
| mesh[0].qualifier_ui | Q000494 |
| mesh[0].descriptor_ui | D000584 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | pharmacology |
| mesh[0].descriptor_name | Amiloride |
| mesh[1].qualifier_ui | Q000494 |
| mesh[1].descriptor_ui | D000970 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | pharmacology |
| mesh[1].descriptor_name | Antineoplastic Agents |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D017209 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Apoptosis |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D001343 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Autophagy |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D049109 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Cell Proliferation |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D059865 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Endoplasmic Reticulum Stress |
| mesh[6].qualifier_ui | Q000494 |
| mesh[6].descriptor_ui | D006146 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | pharmacology |
| mesh[6].descriptor_name | Guanidines |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D006801 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Humans |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D061986 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | MCF-7 Cells |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D009369 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Neoplasms |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D000074082 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | Sodium-Hydrogen Exchanger 1 |
| mesh[11].qualifier_ui | Q000378 |
| mesh[11].descriptor_ui | D000074082 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | metabolism |
| mesh[11].descriptor_name | Sodium-Hydrogen Exchanger 1 |
| mesh[12].qualifier_ui | Q000187 |
| mesh[12].descriptor_ui | D018874 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | drug effects |
| mesh[12].descriptor_name | Spheroids, Cellular |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D018874 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Spheroids, Cellular |
| mesh[14].qualifier_ui | Q000494 |
| mesh[14].descriptor_ui | D013450 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | pharmacology |
| mesh[14].descriptor_name | Sulfones |
| mesh[15].qualifier_ui | Q000494 |
| mesh[15].descriptor_ui | D000584 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pharmacology |
| mesh[15].descriptor_name | Amiloride |
| mesh[16].qualifier_ui | Q000494 |
| mesh[16].descriptor_ui | D000970 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | pharmacology |
| mesh[16].descriptor_name | Antineoplastic Agents |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D017209 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Apoptosis |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D001343 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Autophagy |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D049109 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Cell Proliferation |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D059865 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Endoplasmic Reticulum Stress |
| mesh[21].qualifier_ui | Q000494 |
| mesh[21].descriptor_ui | D006146 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | pharmacology |
| mesh[21].descriptor_name | Guanidines |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D006801 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Humans |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D061986 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | MCF-7 Cells |
| mesh[24].qualifier_ui | Q000378 |
| mesh[24].descriptor_ui | D009369 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | metabolism |
| mesh[24].descriptor_name | Neoplasms |
| mesh[25].qualifier_ui | Q000235 |
| mesh[25].descriptor_ui | D000074082 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | genetics |
| mesh[25].descriptor_name | Sodium-Hydrogen Exchanger 1 |
| mesh[26].qualifier_ui | Q000378 |
| mesh[26].descriptor_ui | D000074082 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | metabolism |
| mesh[26].descriptor_name | Sodium-Hydrogen Exchanger 1 |
| mesh[27].qualifier_ui | Q000187 |
| mesh[27].descriptor_ui | D018874 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | drug effects |
| mesh[27].descriptor_name | Spheroids, Cellular |
| mesh[28].qualifier_ui | Q000378 |
| mesh[28].descriptor_ui | D018874 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | metabolism |
| mesh[28].descriptor_name | Spheroids, Cellular |
| mesh[29].qualifier_ui | Q000494 |
| mesh[29].descriptor_ui | D013450 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | pharmacology |
| mesh[29].descriptor_name | Sulfones |
| type | article |
| title | Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1 |
| biblio.issue | 1 |
| biblio.volume | 10 |
| biblio.last_page | 5800 |
| biblio.first_page | 5800 |
| topics[0].id | https://openalex.org/T11924 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9854999780654907 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Polyamine Metabolism and Applications |
| topics[1].id | https://openalex.org/T11178 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9797000288963318 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Receptor Mechanisms and Signaling |
| topics[2].id | https://openalex.org/T12626 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.97079998254776 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2738 |
| topics[2].subfield.display_name | Psychiatry and Mental health |
| topics[2].display_name | Cancer, Stress, Anesthesia, and Immune Response |
| is_xpac | False |
| apc_list.value | 1890 |
| apc_list.currency | EUR |
| apc_list.value_usd | 2190 |
| apc_paid.value | 1890 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 2190 |
| concepts[0].id | https://openalex.org/C2779608910 |
| concepts[0].level | 3 |
| concepts[0].score | 0.5994196534156799 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q419995 |
| concepts[0].display_name | Amiloride |
| concepts[1].id | https://openalex.org/C53227056 |
| concepts[1].level | 3 |
| concepts[1].score | 0.5875611305236816 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q189152 |
| concepts[1].display_name | Viability assay |
| concepts[2].id | https://openalex.org/C114574056 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5280661582946777 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7553395 |
| concepts[2].display_name | Sodium–hydrogen antiporter |
| concepts[3].id | https://openalex.org/C185592680 |
| concepts[3].level | 0 |
| concepts[3].score | 0.5240533351898193 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[3].display_name | Chemistry |
| concepts[4].id | https://openalex.org/C31573885 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5091552138328552 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q304484 |
| concepts[4].display_name | Programmed cell death |
| concepts[5].id | https://openalex.org/C62112901 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4682173728942871 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q189159 |
| concepts[5].display_name | Cell growth |
| concepts[6].id | https://openalex.org/C96232424 |
| concepts[6].level | 3 |
| concepts[6].score | 0.46191146969795227 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q4118072 |
| concepts[6].display_name | Cancer cell |
| concepts[7].id | https://openalex.org/C502942594 |
| concepts[7].level | 1 |
| concepts[7].score | 0.41936951875686646 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[7].display_name | Cancer research |
| concepts[8].id | https://openalex.org/C98274493 |
| concepts[8].level | 1 |
| concepts[8].score | 0.39650028944015503 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[8].display_name | Pharmacology |
| concepts[9].id | https://openalex.org/C190283241 |
| concepts[9].level | 2 |
| concepts[9].score | 0.3873501420021057 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q14599311 |
| concepts[9].display_name | Apoptosis |
| concepts[10].id | https://openalex.org/C121608353 |
| concepts[10].level | 2 |
| concepts[10].score | 0.2896879315376282 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[10].display_name | Cancer |
| concepts[11].id | https://openalex.org/C86803240 |
| concepts[11].level | 0 |
| concepts[11].score | 0.2643823027610779 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[11].display_name | Biology |
| concepts[12].id | https://openalex.org/C55493867 |
| concepts[12].level | 1 |
| concepts[12].score | 0.22517859935760498 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[12].display_name | Biochemistry |
| concepts[13].id | https://openalex.org/C71924100 |
| concepts[13].level | 0 |
| concepts[13].score | 0.17884522676467896 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[13].display_name | Medicine |
| concepts[14].id | https://openalex.org/C126322002 |
| concepts[14].level | 1 |
| concepts[14].score | 0.11098802089691162 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[14].display_name | Internal medicine |
| concepts[15].id | https://openalex.org/C537181965 |
| concepts[15].level | 2 |
| concepts[15].score | 0.08231392502784729 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q658 |
| concepts[15].display_name | Sodium |
| concepts[16].id | https://openalex.org/C178790620 |
| concepts[16].level | 1 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[16].display_name | Organic chemistry |
| keywords[0].id | https://openalex.org/keywords/amiloride |
| keywords[0].score | 0.5994196534156799 |
| keywords[0].display_name | Amiloride |
| keywords[1].id | https://openalex.org/keywords/viability-assay |
| keywords[1].score | 0.5875611305236816 |
| keywords[1].display_name | Viability assay |
| keywords[2].id | https://openalex.org/keywords/sodium–hydrogen-antiporter |
| keywords[2].score | 0.5280661582946777 |
| keywords[2].display_name | Sodium–hydrogen antiporter |
| keywords[3].id | https://openalex.org/keywords/chemistry |
| keywords[3].score | 0.5240533351898193 |
| keywords[3].display_name | Chemistry |
| keywords[4].id | https://openalex.org/keywords/programmed-cell-death |
| keywords[4].score | 0.5091552138328552 |
| keywords[4].display_name | Programmed cell death |
| keywords[5].id | https://openalex.org/keywords/cell-growth |
| keywords[5].score | 0.4682173728942871 |
| keywords[5].display_name | Cell growth |
| keywords[6].id | https://openalex.org/keywords/cancer-cell |
| keywords[6].score | 0.46191146969795227 |
| keywords[6].display_name | Cancer cell |
| keywords[7].id | https://openalex.org/keywords/cancer-research |
| keywords[7].score | 0.41936951875686646 |
| keywords[7].display_name | Cancer research |
| keywords[8].id | https://openalex.org/keywords/pharmacology |
| keywords[8].score | 0.39650028944015503 |
| keywords[8].display_name | Pharmacology |
| keywords[9].id | https://openalex.org/keywords/apoptosis |
| keywords[9].score | 0.3873501420021057 |
| keywords[9].display_name | Apoptosis |
| keywords[10].id | https://openalex.org/keywords/cancer |
| keywords[10].score | 0.2896879315376282 |
| keywords[10].display_name | Cancer |
| keywords[11].id | https://openalex.org/keywords/biology |
| keywords[11].score | 0.2643823027610779 |
| keywords[11].display_name | Biology |
| keywords[12].id | https://openalex.org/keywords/biochemistry |
| keywords[12].score | 0.22517859935760498 |
| keywords[12].display_name | Biochemistry |
| keywords[13].id | https://openalex.org/keywords/medicine |
| keywords[13].score | 0.17884522676467896 |
| keywords[13].display_name | Medicine |
| keywords[14].id | https://openalex.org/keywords/internal-medicine |
| keywords[14].score | 0.11098802089691162 |
| keywords[14].display_name | Internal medicine |
| keywords[15].id | https://openalex.org/keywords/sodium |
| keywords[15].score | 0.08231392502784729 |
| keywords[15].display_name | Sodium |
| language | en |
| locations[0].id | doi:10.1038/s41598-020-62430-z |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S196734849 |
| locations[0].source.issn | 2045-2322 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2045-2322 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Scientific Reports |
| locations[0].source.host_organization | https://openalex.org/P4310319908 |
| locations[0].source.host_organization_name | Nature Portfolio |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319908 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.nature.com/articles/s41598-020-62430-z.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Scientific Reports |
| locations[0].landing_page_url | https://doi.org/10.1038/s41598-020-62430-z |
| locations[1].id | pmid:32242030 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Scientific reports |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/32242030 |
| locations[2].id | pmh:oai:pure.atira.dk:openaire_cris_publications/a1086f7e-8435-462f-9b51-1cf7a85a48be |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400216 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Research Portal (King's College London) |
| locations[2].source.host_organization | https://openalex.org/I183935753 |
| locations[2].source.host_organization_name | King's College London |
| locations[2].source.host_organization_lineage | https://openalex.org/I183935753 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://curis.ku.dk/portal/da/publications/pyrazine-ringbased-nah-exchanger-nhe-inhibitors-potently-inhibit-cancer-cell-growth-in-3d-culture-independent-of-nhe1(a1086f7e-8435-462f-9b51-1cf7a85a48be).html |
| locations[3].id | pmh:oai:HAL:hal-02570266v1 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306402512 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[3].source.host_organization | https://openalex.org/I1294671590 |
| locations[3].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[3].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Journal articles |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-62430-z⟩ |
| locations[3].landing_page_url | https://hal.science/hal-02570266 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:7118118 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Sci Rep |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7118118 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5057064256 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4139-1218 |
| authorships[0].author.display_name | Michala G. Rolver |
| authorships[0].countries | DK |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I124055696 |
| authorships[0].affiliations[0].raw_affiliation_string | UCPH - University of Copenhagen = Københavns Universitet (Nørregade 10, 1165 København, Danemark - Denmark) |
| authorships[0].institutions[0].id | https://openalex.org/I124055696 |
| authorships[0].institutions[0].ror | https://ror.org/035b05819 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I124055696 |
| authorships[0].institutions[0].country_code | DK |
| authorships[0].institutions[0].display_name | University of Copenhagen |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Michala G. Rolver |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | UCPH - University of Copenhagen = Københavns Universitet (Nørregade 10, 1165 København, Danemark - Denmark) |
| authorships[1].author.id | https://openalex.org/A5044757313 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-9757-8383 |
| authorships[1].author.display_name | Line O. Elingaard-Larsen |
| authorships[1].countries | DK |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I124055696 |
| authorships[1].affiliations[0].raw_affiliation_string | UCPH - University of Copenhagen = Københavns Universitet (Nørregade 10, 1165 København, Danemark - Denmark) |
| authorships[1].institutions[0].id | https://openalex.org/I124055696 |
| authorships[1].institutions[0].ror | https://ror.org/035b05819 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I124055696 |
| authorships[1].institutions[0].country_code | DK |
| authorships[1].institutions[0].display_name | University of Copenhagen |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Line O. Elingaard-Larsen |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | UCPH - University of Copenhagen = Københavns Universitet (Nørregade 10, 1165 København, Danemark - Denmark) |
| authorships[2].author.id | https://openalex.org/A5058583921 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6693-1524 |
| authorships[2].author.display_name | Anne Poder Andersen |
| authorships[2].countries | DK |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I124055696 |
| authorships[2].affiliations[0].raw_affiliation_string | UCPH - University of Copenhagen = Københavns Universitet (Nørregade 10, 1165 København, Danemark - Denmark) |
| authorships[2].institutions[0].id | https://openalex.org/I124055696 |
| authorships[2].institutions[0].ror | https://ror.org/035b05819 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I124055696 |
| authorships[2].institutions[0].country_code | DK |
| authorships[2].institutions[0].display_name | University of Copenhagen |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Anne P. Andersen |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | UCPH - University of Copenhagen = Københavns Universitet (Nørregade 10, 1165 København, Danemark - Denmark) |
| authorships[3].author.id | https://openalex.org/A5087610768 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-7711-8830 |
| authorships[3].author.display_name | Laurent Counillon |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210091024 |
| authorships[3].affiliations[0].raw_affiliation_string | LP2M - Laboratoire de PhysioMédecine Moléculaire (Parc Valrose 06108 Nice Cedex 2 - France) |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I201841394, https://openalex.org/I4210117840 |
| authorships[3].affiliations[1].raw_affiliation_string | COMUE UCA - COMUE Université Côte d'Azur (2015-2019) (Parc Valrose, 28, avenue Valrose 06108 Nice Cedex 2 - France) |
| authorships[3].institutions[0].id | https://openalex.org/I4210117840 |
| authorships[3].institutions[0].ror | https://ror.org/03bnma344 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I201841394, https://openalex.org/I4210096427, https://openalex.org/I4210117840 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Institut de Biologie Valrose |
| authorships[3].institutions[1].id | https://openalex.org/I4210091024 |
| authorships[3].institutions[1].ror | https://ror.org/00c3ktd57 |
| authorships[3].institutions[1].type | facility |
| authorships[3].institutions[1].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I201841394, https://openalex.org/I4210091024, https://openalex.org/I4210096427 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Laboratoire de PhysioMédecine Moléculaire |
| authorships[3].institutions[2].id | https://openalex.org/I201841394 |
| authorships[3].institutions[2].ror | https://ror.org/019tgvf94 |
| authorships[3].institutions[2].type | education |
| authorships[3].institutions[2].lineage | https://openalex.org/I201841394 |
| authorships[3].institutions[2].country_code | FR |
| authorships[3].institutions[2].display_name | Université Côte d'Azur |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Laurent Counillon |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | COMUE UCA - COMUE Université Côte d'Azur (2015-2019) (Parc Valrose, 28, avenue Valrose 06108 Nice Cedex 2 - France), LP2M - Laboratoire de PhysioMédecine Moléculaire (Parc Valrose 06108 Nice Cedex 2 - France) |
| authorships[4].author.id | https://openalex.org/A5015579145 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-3044-7714 |
| authorships[4].author.display_name | Stine F. Pedersen |
| authorships[4].countries | DK |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I124055696 |
| authorships[4].affiliations[0].raw_affiliation_string | UCPH - University of Copenhagen = Københavns Universitet (Nørregade 10, 1165 København, Danemark - Denmark) |
| authorships[4].institutions[0].id | https://openalex.org/I124055696 |
| authorships[4].institutions[0].ror | https://ror.org/035b05819 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I124055696 |
| authorships[4].institutions[0].country_code | DK |
| authorships[4].institutions[0].display_name | University of Copenhagen |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Stine F. Pedersen |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | UCPH - University of Copenhagen = Københavns Universitet (Nørregade 10, 1165 København, Danemark - Denmark) |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.nature.com/articles/s41598-020-62430-z.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Pyrazine ring-based Na+/H+ exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1 |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11924 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9854999780654907 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Polyamine Metabolism and Applications |
| related_works | https://openalex.org/W1968498573, https://openalex.org/W2396092200, https://openalex.org/W2280184810, https://openalex.org/W2039337816, https://openalex.org/W2089675043, https://openalex.org/W2031051652, https://openalex.org/W2369223204, https://openalex.org/W4249458258, https://openalex.org/W2285572504, https://openalex.org/W2410120624 |
| cited_by_count | 54 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 13 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 9 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 14 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 14 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 2 |
| locations_count | 5 |
| best_oa_location.id | doi:10.1038/s41598-020-62430-z |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S196734849 |
| best_oa_location.source.issn | 2045-2322 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2045-2322 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Scientific Reports |
| best_oa_location.source.host_organization | https://openalex.org/P4310319908 |
| best_oa_location.source.host_organization_name | Nature Portfolio |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319908 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.nature.com/articles/s41598-020-62430-z.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Scientific Reports |
| best_oa_location.landing_page_url | https://doi.org/10.1038/s41598-020-62430-z |
| primary_location.id | doi:10.1038/s41598-020-62430-z |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S196734849 |
| primary_location.source.issn | 2045-2322 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2045-2322 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Scientific Reports |
| primary_location.source.host_organization | https://openalex.org/P4310319908 |
| primary_location.source.host_organization_name | Nature Portfolio |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319908 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.nature.com/articles/s41598-020-62430-z.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Scientific Reports |
| primary_location.landing_page_url | https://doi.org/10.1038/s41598-020-62430-z |
| publication_date | 2020-04-02 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2889646458, https://openalex.org/W1271389891, https://openalex.org/W2079142824, https://openalex.org/W2078684128, https://openalex.org/W2790501767, https://openalex.org/W1483613051, https://openalex.org/W2129345554, https://openalex.org/W1965301458, https://openalex.org/W2565874663, https://openalex.org/W2588581252, https://openalex.org/W2973215115, https://openalex.org/W2087784543, https://openalex.org/W2022128427, https://openalex.org/W1985874210, https://openalex.org/W2060337978, https://openalex.org/W2026236710, https://openalex.org/W2094454542, https://openalex.org/W2136445803, https://openalex.org/W2992568708, https://openalex.org/W2773319572, https://openalex.org/W2083266848, https://openalex.org/W1574359829, https://openalex.org/W2548966581, https://openalex.org/W2888001388, https://openalex.org/W2063193866, https://openalex.org/W2158998533, https://openalex.org/W2601913258, https://openalex.org/W2973039076, https://openalex.org/W2122041784, https://openalex.org/W2038014670, https://openalex.org/W2415905463, https://openalex.org/W1674029742, https://openalex.org/W2083641709, https://openalex.org/W1965947045, https://openalex.org/W2022641267, https://openalex.org/W2052043745, https://openalex.org/W2039386747, https://openalex.org/W2043360750, https://openalex.org/W1488213408, https://openalex.org/W1574083581, https://openalex.org/W2750428665, https://openalex.org/W2774483419, https://openalex.org/W2550697711, https://openalex.org/W1975198903, https://openalex.org/W2289080838, https://openalex.org/W1948560807, https://openalex.org/W2030139214, https://openalex.org/W2158814411, https://openalex.org/W2005592863, https://openalex.org/W2521065763, https://openalex.org/W2515247624, https://openalex.org/W1987615998, https://openalex.org/W1558696846, https://openalex.org/W2050573392, https://openalex.org/W2155631267, https://openalex.org/W2088687690, https://openalex.org/W2055271975, https://openalex.org/W2150696151, https://openalex.org/W2984395468, https://openalex.org/W637151678, https://openalex.org/W1901286517 |
| referenced_works_count | 61 |
| abstract_inverted_index | |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 5 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.93441669 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |