Quantification of [99mTc]Tc-HDP bone SPECT/CT: can we improve the body weight based standardized uptake value with a more robust normalization? Article Swipe

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Medicine Nuclear medicine Hounsfield scale Orthopedic surgery Linear regression Standardized uptake value Correlation Normalization (sociology) Lumbar vertebrae Cardiac imaging Lumbar Radiology Computed tomography Positron emission tomography Surgery Mathematics Statistics Sociology Anthropology Geometry

Tiberiu Damian , Noel Spielhofer , Jakob Heimer , Alexander Sauter , Cristina Popescu , Daniel Hausmann , Jason L. Manser , Karim Eid , R. Huch , Irene A. Burger ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1186/s13550-024-01167-6 · OA: W4404524530

Using an age, bone density and weight-based normalization significantly decreased the interindividual variability of normal uptake on quantitative SPECT/CT compared to the regularly used BW adjusted SUV<sub>BW</sub>. However, a generalized normalization is difficult in the presence of strong patient effects, not attributable to the measured clinical variables.