Quantification of the effects of n-π* interactions on the H-bonding properties of amide groups Article Swipe

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Fergal E. Hanna , Andrew D. Bond , Christopher A. Hunter ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1039/d4sc08331h

The free energy contribution due to cooperativity between an n–π* interaction and a H-bond was found to be within the experimental error, suggesting that associated contributions to the stability of folded proteins are small.

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Cooperativity Amide Chemistry Hydrogen bond Cooperative binding Interaction energy Stability (learning theory) Computational chemistry Crystallography Chemical physics Molecule Organic chemistry Computer science Biochemistry Binding site Machine learning

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Type: article
Language: en
Landing Page: https://doi.org/10.1039/d4sc08331h
OA Status: diamond
Cited By: 4
References: 36
Related Works: 10
OpenAlex ID: https://openalex.org/W4409147353

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DOI: https://doi.org/10.1039/d4sc08331h

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Title: Quantification of the effects of n-π* interactions on the H-bonding properties of amide groups

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Language: en

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Publication year: 2025

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Publication date: 2025-01-01

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Authors: Fergal E. Hanna, Andrew D. Bond, Christopher A. Hunter

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Landing page: https://doi.org/10.1039/d4sc08331h

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Concepts: Cooperativity, Amide, Chemistry, Hydrogen bond, Cooperative binding, Interaction energy, Stability (learning theory), Computational chemistry, Crystallography, Chemical physics, Molecule, Organic chemistry, Computer science, Biochemistry, Binding site, Machine learning

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citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	True