Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials Article Swipe
María M. Cobo
,
Caroline Hartley
,
Deniz Gursul
,
Foteini Andritsou
,
Marianne van der Vaart
,
Gabriela Schmidt Mellado
,
Luke Baxter
,
Eugene Duff
,
Miranda Buckle
,
Ria Evans Fry
,
Gabrielle Green
,
Amy Hoskin
,
Richard Rogers
,
Eleri Adams
,
Fiona Moultrie
,
Rebeccah Slater
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.7554/elife.65266
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.7554/elife.65266
Despite the high burden of pain experienced by hospitalised neonates, there are few analgesics with proven efficacy. Testing analgesics in neonates is experimentally and ethically challenging and minimising the number of neonates required to demonstrate efficacy is essential. EEG (electroencephalography)-derived measures of noxious-evoked brain activity can be used to assess analgesic efficacy; however, as variability exists in neonate’s responses to painful procedures, large sample sizes are often required. Here, we present an experimental paradigm to account for individual differences in noxious-evoked baseline sensitivity which can be used to improve the design of analgesic trials in neonates. The paradigm is developed and tested across four observational studies using clinical, experimental, and simulated data (92 neonates). We provide evidence of the efficacy of gentle brushing and paracetamol, substantiating the need for randomised controlled trials of these interventions. This work provides an important step towards safe, cost-effective clinical trials of analgesics in neonates.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.65266
- OA Status
- gold
- Cited By
- 23
- References
- 89
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3154492132
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3154492132Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7554/elife.65266Digital Object Identifier
- Title
-
Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trialsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-04-13Full publication date if available
- Authors
-
María M. Cobo, Caroline Hartley, Deniz Gursul, Foteini Andritsou, Marianne van der Vaart, Gabriela Schmidt Mellado, Luke Baxter, Eugene Duff, Miranda Buckle, Ria Evans Fry, Gabrielle Green, Amy Hoskin, Richard Rogers, Eleri Adams, Fiona Moultrie, Rebeccah SlaterList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.65266Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.7554/elife.65266Direct OA link when available
- Concepts
-
Analgesic, Noxious stimulus, Medicine, Observational study, Clinical trial, Electroencephalography, Anesthesia, Randomized controlled trial, Psychological intervention, Intensive care medicine, Nociception, Surgery, Internal medicine, Psychiatry, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
23Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 8, 2023: 4, 2022: 4, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
89Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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