Quantifying Tensile Forces at Cell–Cell Junctions with a DNA-based Fluorescent Probe Article Swipe
Bin Zhao
,
Ningwei Li
,
Tianfa Xie
,
Chungwen Liang
,
Yousef Bagheri
,
Yubing Sun
,
Mingxu You
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.01.07.897249
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.01.07.897249
SUMMARY Cells are physically contacting with each other. Direct and precise quantification of forces at cell–cell junctions is still challenging. Herein, we have developed a DNA-based ratiometric fluorescent probe, termed DNAMeter, to quantify intercellular tensile forces. These lipid-modified DNAMeters can spontaneously anchor onto live cell membranes. The DNAMeter consists of two self-assembled DNA hairpins of different force tolerance. Once the intercellular tension exceeds the force tolerance to unfold a DNA hairpin, a specific fluorescence signal will be activated, which enables the real-time imaging and quantification of tensile forces. Using E-cadherin-modified DNAMeter as an example, we have demonstrated an approach to quantify, at the molecular level, the magnitude and distribution of E-cadherin tension among epithelial cells. Compatible with readily accessible fluorescence microscopes, these easy-to-use DNA tension probes can be broadly used to quantify mechanotransduction in collective cell behaviors.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.01.07.897249
- https://www.biorxiv.org/content/biorxiv/early/2020/01/07/2020.01.07.897249.full.pdf
- OA Status
- green
- Cited By
- 3
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3000115108
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3000115108Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.01.07.897249Digital Object Identifier
- Title
-
Quantifying Tensile Forces at Cell–Cell Junctions with a DNA-based Fluorescent ProbeWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-07Full publication date if available
- Authors
-
Bin Zhao, Ningwei Li, Tianfa Xie, Chungwen Liang, Yousef Bagheri, Yubing Sun, Mingxu YouList of authors in order
- Landing page
-
https://doi.org/10.1101/2020.01.07.897249Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2020/01/07/2020.01.07.897249.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/01/07/2020.01.07.897249.full.pdfDirect OA link when available
- Concepts
-
Mechanotransduction, Biophysics, Fluorescence, DNA, Tension (geology), Cell, Fluorescence microscope, Intracellular, Membrane, Live cell imaging, Cadherin, Nanotechnology, Chemistry, Cell membrane, Cell biology, Ultimate tensile strength, Materials science, Optics, Biology, Physics, Biochemistry, Composite materialTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
62Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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