Abstract Copper‐exchanged zeolite omega (Cu‐omega) is a potent material for the selective conversion of methane‐to‐methanol (MtM) via the oxygen looping approach. However, its performance exhibits substantial variation depending on the operational conditions. Under an isothermal temperature regime, Cu‐omega demonstrates subdued activity below 230 °C, but experiences a remarkable increase in activity at 290 °C. Applying a high‐temperature activation protocol at 450 °C causes a rapid deactivation of the material. Th…