Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone Article Swipe
Francesca Catto
,
Ehsan Dadgar‐Kiani
,
Daniel S. Kirschenbaum
,
Athena Economides
,
Anna Maria Reuss
,
Chiara Trevisan
,
Davide Caredio
,
Delic Mirzet
,
Lukas Frick
,
Ulrike Weber‐Stadlbauer
,
Sergey Litvinov
,
Petros Koumoutsakos
,
Jin Hyung Lee
,
Adriano Aguzzi
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.15.608042
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.15.608042
A hallmark of Alzheimer's disease (AD) is the extracellular aggregation of toxic amyloid-beta (Aβ) peptides in form of plaques. Here, we identify netoglitazone, an antidiabetic compound previously tested in humans, as an Aβ aggregation antagonist. Netoglitazone improved cognition and reduced microglia activity in a mouse model of AD. Using quantitative whole-brain three-dimensional histology (Q3D), we precisely identified brain regions where netoglitazone reduced the number and size of Aβ plaques. We demonstrate the utility of Q3D in preclinical drug evaluation for AD by providing a high-resolution brain-wide view of drug efficacy. Applying Q3D has the potential to improve pre-clinical drug evaluation by providing information that can help identify mechanisms leading to brain region-specific drug efficacy.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.08.15.608042
- https://www.biorxiv.org/content/biorxiv/early/2024/08/17/2024.08.15.608042.full.pdf
- OA Status
- green
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401662192
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401662192Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2024.08.15.608042Digital Object Identifier
- Title
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Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazoneWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-08-17Full publication date if available
- Authors
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Francesca Catto, Ehsan Dadgar‐Kiani, Daniel S. Kirschenbaum, Athena Economides, Anna Maria Reuss, Chiara Trevisan, Davide Caredio, Delic Mirzet, Lukas Frick, Ulrike Weber‐Stadlbauer, Sergey Litvinov, Petros Koumoutsakos, Jin Hyung Lee, Adriano AguzziList of authors in order
- Landing page
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https://doi.org/10.1101/2024.08.15.608042Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2024/08/17/2024.08.15.608042.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2024/08/17/2024.08.15.608042.full.pdfDirect OA link when available
- Concepts
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Drug, Microglia, Amyloid (mycology), Pharmacology, Neuroscience, Efficacy, Antagonist, Drug discovery, Drug development, Amyloid β, Medicine, Disease, Chemistry, Biology, Pathology, Internal medicine, Biochemistry, Receptor, InflammationTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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66Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works_count | 66 |
| abstract_inverted_index.A | 0 |
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| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5101958720, https://openalex.org/A5026438561 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 14 |
| corresponding_institution_ids | https://openalex.org/I202697423, https://openalex.org/I4210100468, https://openalex.org/I97018004 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7900000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.20930996 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |