Quantitative evaluation of the dynamic activity of HeLa cells in different viability states using dynamic full-field optical coherence microscopy Article Swipe
Soongho Park
,
Thien Nguyen
,
Emilie Benoit
,
Dan L. Sackett
,
Marcial Garmendia‐Cedillos
,
Randall Pursley
,
Claude Boccara
,
Amir Gandjbakhche
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1364/boe.436330
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1364/boe.436330
Dynamic full-field optical coherence microscopy (DFFOCM) was used to characterize the intracellular dynamic activities and cytoskeleton of HeLa cells in different viability states. HeLa cell samples were continuously monitored for 24 hours and compared with histological examination to confirm the cell viability states. The averaged mean frequency and magnitude observed in healthy cells were 4.79±0.5 Hz and 2.44±1.06, respectively. In dead cells, the averaged mean frequency was shifted to 8.57±0.71 Hz, whereas the magnitude was significantly decreased to 0.53±0.25. This cell dynamic activity analysis using DFFOCM is expected to replace conventional time-consuming and biopsies-required histological or biochemical methods.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1364/boe.436330
- OA Status
- gold
- Cited By
- 20
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3195360602
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3195360602Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1364/boe.436330Digital Object Identifier
- Title
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Quantitative evaluation of the dynamic activity of HeLa cells in different viability states using dynamic full-field optical coherence microscopyWork title
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articleOpenAlex work type
- Language
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enPrimary language
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2021Year of publication
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2021-08-17Full publication date if available
- Authors
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Soongho Park, Thien Nguyen, Emilie Benoit, Dan L. Sackett, Marcial Garmendia‐Cedillos, Randall Pursley, Claude Boccara, Amir GandjbakhcheList of authors in order
- Landing page
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https://doi.org/10.1364/boe.436330Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1364/boe.436330Direct OA link when available
- Concepts
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HeLa, Viability assay, Microscopy, Coherence (philosophical gambling strategy), Biophysics, Intracellular, Optical coherence tomography, Optical microscope, Optics, Materials science, Cell, Chemistry, Biology, Cell biology, Physics, Scanning electron microscope, Biochemistry, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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20Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 8, 2023: 4, 2022: 3Per-year citation counts (last 5 years)
- References (count)
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37Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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