Quantitative high-resolution imaging of mouse nephron formation to study Wnt signaling dynamics Article Swipe
Nobuko Tsuchida-Straeten
,
Stefanie Hammer
,
Aliaksandr Halavatyi
,
Christian Tischer
,
Gislene Pereira
,
Matias Simons
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.06.30.662340
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.06.30.662340
Introduction Nephron formation is initiated when Wnt9b from the ureteric bud acts on nephron progenitor cells in the metanephric mesenchyme. For mouse embryonic kidneys, this process can be studied in real time using ex vivo organ cultures. Previous imaging methods relied on Transwell filters with a long distance between objective and sample as well as low signal-to-noise ratio due to the filter membrane. Moreover, Wnt signaling was previously visualized with the expression reporters TCF/Lef:H2B-GFP . Methods We developed an ex vivo culture system based on low-volume media and fibronectin coating for real time imaging. We further made use of endogenously tagged Cherry-Lef1 and Ctnnb1-Venus reporter mouse lines as reporters for Wnt signaling during kidney development. Furthermore, we established an adaptive feedback microscopy pipeline to track the signal with high resolution. Results Using these approaches, we found that Cherry-Lef1 proteins are only expressed in the nascent nephron and derivatives. Expression is graded along distal-proximal nephron axis suggesting that the ureteric bud-derived Wnt9b is controlling its expression. Interestingly, we observed that Cherry-Lef1 gradient shifts from distal to proximal axis during nephron patterning. β-catenin - Venus, on the other hand, first became visible in the ureteric bud, then in the nascent nephron after Lef1. Conclusions Using a novel imaging approach we demonstrate a dynamic regulation of Wnt signaling that correlates with nephrogenesis in mouse kidney development. Combined with our two new Wnt signaling reporters, nephron formation can be studied in real-time with high resolution.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.06.30.662340
- https://www.biorxiv.org/content/biorxiv/early/2025/07/03/2025.06.30.662340.full.pdf
- OA Status
- green
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412009540
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412009540Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.06.30.662340Digital Object Identifier
- Title
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Quantitative high-resolution imaging of mouse nephron formation to study Wnt signaling dynamicsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-03Full publication date if available
- Authors
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Nobuko Tsuchida-Straeten, Stefanie Hammer, Aliaksandr Halavatyi, Christian Tischer, Gislene Pereira, Matias SimonsList of authors in order
- Landing page
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https://doi.org/10.1101/2025.06.30.662340Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2025/07/03/2025.06.30.662340.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2025/07/03/2025.06.30.662340.full.pdfDirect OA link when available
- Concepts
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Wnt signaling pathway, Nephron, Dynamics (music), High resolution, Cell biology, Signal transduction, Biology, Kidney, Geography, Remote sensing, Physics, Endocrinology, AcousticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.observed | 168 |
| abstract_inverted_index.pipeline | 123 |
| abstract_inverted_index.proteins | 139 |
| abstract_inverted_index.proximal | 176 |
| abstract_inverted_index.reporter | 105 |
| abstract_inverted_index.ureteric | 10, 159, 193 |
| abstract_inverted_index.Moreover, | 64 |
| abstract_inverted_index.Transwell | 43 |
| abstract_inverted_index.cultures. | 37 |
| abstract_inverted_index.developed | 78 |
| abstract_inverted_index.embryonic | 23 |
| abstract_inverted_index.expressed | 142 |
| abstract_inverted_index.formation | 3, 233 |
| abstract_inverted_index.initiated | 5 |
| abstract_inverted_index.membrane. | 63 |
| abstract_inverted_index.objective | 50 |
| abstract_inverted_index.real-time | 238 |
| abstract_inverted_index.reporters | 73, 109 |
| abstract_inverted_index.signaling | 66, 112, 215, 230 |
| abstract_inverted_index.Expression | 149 |
| abstract_inverted_index.correlates | 217 |
| abstract_inverted_index.expression | 72 |
| abstract_inverted_index.low-volume | 86 |
| abstract_inverted_index.microscopy | 122 |
| abstract_inverted_index.previously | 68 |
| abstract_inverted_index.progenitor | 15 |
| abstract_inverted_index.regulation | 212 |
| abstract_inverted_index.reporters, | 231 |
| abstract_inverted_index.suggesting | 156 |
| abstract_inverted_index.visualized | 69 |
| abstract_inverted_index.β-catenin | 181 |
| abstract_inverted_index.Cherry-Lef1 | 102, 138, 170 |
| abstract_inverted_index.Conclusions | 202 |
| abstract_inverted_index.approaches, | 134 |
| abstract_inverted_index.bud-derived | 160 |
| abstract_inverted_index.controlling | 163 |
| abstract_inverted_index.demonstrate | 209 |
| abstract_inverted_index.established | 118 |
| abstract_inverted_index.expression. | 165 |
| abstract_inverted_index.fibronectin | 89 |
| abstract_inverted_index.mesenchyme. | 20 |
| abstract_inverted_index.metanephric | 19 |
| abstract_inverted_index.patterning. | 180 |
| abstract_inverted_index.resolution. | 130, 241 |
| abstract_inverted_index.Ctnnb1-Venus | 104 |
| abstract_inverted_index.Furthermore, | 116 |
| abstract_inverted_index.Introduction | 1 |
| abstract_inverted_index.derivatives. | 148 |
| abstract_inverted_index.development. | 115, 223 |
| abstract_inverted_index.endogenously | 100 |
| abstract_inverted_index.nephrogenesis | 219 |
| abstract_inverted_index.Interestingly, | 166 |
| abstract_inverted_index.TCF/Lef:H2B-GFP | 74 |
| abstract_inverted_index.distal-proximal | 153 |
| abstract_inverted_index.signal-to-noise | 57 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 6 |
| citation_normalized_percentile.value | 0.31404418 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |