Quantum dot-based FRET nanosensors for Talin-membrane assembly and mechanosensing Article Swipe
Audrey Ntadambanya
,
Julien Pernier
,
Violaine David
,
Kimihiro Susumu
,
Igor L. Medintz
,
Mayeul Collot
,
Andrey S. Klymchenko
,
Niko Hildebrandt
,
Isabelle Le Potier
,
Christophe Le Clainche
,
Marcelina Cardoso Dos Santos
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2023-3ftxd-v3
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv-2023-3ftxd-v3
Understanding the mechanisms of assembly and disassembly of macromolecular structures in cells relies on solving biomolecular interactions. However, those interactions often remain unclear because tools to track molecular dynamics are not sufficiently resolved in time or space. In this study, we present a straightforward method for resolving inter- and intra- molecular interactions in cell adhesive machinery, using quantum dot (QD) based Förster resonance energy transfer (FRET) nanosensors. Using mechanosensitive protein Talin, one of the major components of focal adhesions, we are investigating mechanosensing ability of proteins to sense and respond to mechanical stimuli. First, we quantified the distances separating Talin and a giant unilamellar vesicle membrane for three Talin variants. These variants differ in molecular length. Second, we investigated the mechanosensing capabilities of Talin, i.e., its conformation changes due to mechanical stretching initiated by cytoskeleton contraction. Our results suggest that in early focal adhesion, Talin undergoes stretching, corresponding to a decrease in the Talin-membrane distance of 2.5 nm. We demonstrate that QD-FRET nanosensors can be applied for the sensitive quantification of mechanosensing with sub-nanometer accuracy.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.26434/chemrxiv-2023-3ftxd-v3
- https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/664388b891aefa6ce1fa01be/original/quantum-dot-based-fret-nanosensors-for-talin-membrane-assembly-and-mechanosensing.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 11
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396934312
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https://openalex.org/W4396934312Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.26434/chemrxiv-2023-3ftxd-v3Digital Object Identifier
- Title
-
Quantum dot-based FRET nanosensors for Talin-membrane assembly and mechanosensingWork title
- Type
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preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-05-15Full publication date if available
- Authors
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Audrey Ntadambanya, Julien Pernier, Violaine David, Kimihiro Susumu, Igor L. Medintz, Mayeul Collot, Andrey S. Klymchenko, Niko Hildebrandt, Isabelle Le Potier, Christophe Le Clainche, Marcelina Cardoso Dos SantosList of authors in order
- Landing page
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https://doi.org/10.26434/chemrxiv-2023-3ftxd-v3Publisher landing page
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https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/664388b891aefa6ce1fa01be/original/quantum-dot-based-fret-nanosensors-for-talin-membrane-assembly-and-mechanosensing.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/664388b891aefa6ce1fa01be/original/quantum-dot-based-fret-nanosensors-for-talin-membrane-assembly-and-mechanosensing.pdfDirect OA link when available
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Quantum dot, Nanosensor, Förster resonance energy transfer, Nanotechnology, Membrane, Chemistry, Biophysics, Materials science, Physics, Fluorescence, Biology, Optics, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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