Quantum Dot Composite Colloids with Layer-by-Layer Shells: Biological Self-Assemblies for Signal Amplified Detection Article Swipe
Wonseok Lee
,
Junhwa Lee
,
Hyunjung Lee
,
Moon Gyu Han
,
Young Ho Ko
,
Chan‐Gi Pack
,
Joonhyuck Park
,
Sungjee Kim
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.5c01965
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.5c01965
Quantum dot composite colloids (QDCCs), submicron-sized colloidal particles incorporating multiple QDs, have been employed as signal reporters. Multiple QDs were encapsulated within the hydrophobic pockets of amphiphilic polyethylenimine derivative (amPEI), forming amPEI-QDCCs with a hydrodynamic size of approximately 100 nm. Fluorescence (FL) correlation spectroscopy revealed that each QDCC encapsulates an average of 20 QDs. A layer-by-layer (LbL) multilayer shell composed of poly(sodium 4-styrenesulfonate) and polyethylenimine polyelectrolytes was added to amPEI QDCCs to improve surface functionalization and structural robustness. Increasing the number of LbL layers reduced copper ion (Cu2+) intrusion and prevented payload exchange of hydrophobic dark quencher in polymersomes, owing to strong hydration and improved shell integrity. The enhanced robustness allowed functionalization of the outer QDCC shell with amines, carboxylates, zwitterionic (ZW) moieties, or their combinations. ZW-functionalized QDCCs (ZW-QDCCs) exhibited colloidal stability across a wide pH range (pH 5-10) and in saturated NaCl solutions. Streptavidin (SA)/biotin-conjugated ZW-QDCCs exhibited specific labeling capabilities in bead assays. A sensitive and rapid enzyme-free FL immunoassay for C-reactive protein (CRP) was developed using sandwich-type immunoassay procedures and the biological self-assembly of the SA/biotin-ZW-QDCC pair. The high multivalency of SA or biotin, combined with the FL intensity of QDCCs, enabled a detection limit of 15.9 fM (1.91 ng/L) within 6 min for 6 amplification rounds─nearly 5 orders of magnitude lower than conventional CRP immunoassays. Our QDCCs demonstrate significant potential for use in ultrasensitive quantification platforms.
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- Language
- en
- Landing Page
- https://doi.org/10.1021/acsnano.5c01965
- OA Status
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- References
- 32
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413356523Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acsnano.5c01965Digital Object Identifier
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Quantum Dot Composite Colloids with Layer-by-Layer Shells: Biological Self-Assemblies for Signal Amplified DetectionWork title
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articleOpenAlex work type
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enPrimary language
- Publication year
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2025Year of publication
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2025-08-20Full publication date if available
- Authors
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Wonseok Lee, Junhwa Lee, Hyunjung Lee, Moon Gyu Han, Young Ho Ko, Chan‐Gi Pack, Joonhyuck Park, Sungjee KimList of authors in order
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https://doi.org/10.1021/acsnano.5c01965Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1021/acsnano.5c01965Direct OA link when available
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Quantum dot, Composite number, Layer (electronics), Colloid, Materials science, Nanotechnology, SIGNAL (programming language), Self-assembly, Layer by layer, Colloidal particle, Optoelectronics, Composite material, Chemical engineering, Computer science, Engineering, Programming languageTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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