Química do estresse: produção do cortisol e seus efeitos no cérebro – uma revisão de literatura Article Swipe

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Airton dos Reis Pereira , Samantha Costa do Carmo , Gustavo Santos Silva , Gerson Cardoso da Silva , Naiara da Silva , Letícia Silva Sena , Jane Sasso Pereira da Costa , Inês Machado , Vinicius Ribeiro Souza , Ignacio de los Santos , Simonne Saraiva Nunes Santana , Rubens Souza ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.54022/shsv6n4-020

O estresse é um fenômeno multifatorial que desencadeia alterações neuroendócrinas mediadas pelo eixo hipotálamo-hipófise-adrenal (HHA), resultando na liberação do cortisol, principal glicocorticoide humano. O excesso ou a exposição crônica a esse hormônio pode modificar circuitos cerebrais fundamentais, especialmente no hipocampo, córtex pré-frontal e amígdala, afetando a memória, o aprendizado, a regulação emocional e a tomada de decisões. Este artigo apresenta uma revisão narrativa da literatura recente (2015–2025), discutindo os mecanismos de produção do cortisol, seus efeitos sobre a neuroplasticidade, a função cognitiva e os impactos clínicos do estresse prolongado. Além disso, busca destacar as contribuições teóricas para a compreensão da neurobiologia do estresse e as implicações práticas para estratégias de prevenção e tratamento. Conclui-se que o equilíbrio entre os efeitos adaptativos e os malefícios do excesso de cortisol depende da intensidade, frequência e duração do estressor, bem como de fatores individuais de resiliência. Considera-se, ainda, que a investigação continuada sobre o tema é fundamental para subsidiar práticas clínicas e políticas públicas de promoção da saúde mental.

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Type: article
Landing Page: https://doi.org/10.54022/shsv6n4-020
PDF: https://ojs.studiespublicacoes.com.br/ojs/index.php/shs/article/download/21275/11737
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OpenAlex ID: https://openalex.org/W4415977051

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DOI: https://doi.org/10.54022/shsv6n4-020

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Title: Química do estresse: produção do cortisol e seus efeitos no cérebro – uma revisão de literatura

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Publication year: 2025

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Publication date: 2025-11-05

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Authors: Airton dos Reis Pereira, Samantha Costa do Carmo, Gustavo Santos Silva, Gerson Cardoso da Silva, Naiara da Silva, Letícia Silva Sena, Jane Sasso Pereira da Costa, Inês Machado, Vinicius Ribeiro Souza, Ignacio de los Santos, Simonne Saraiva Nunes Santana, Rubens Souza

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Landing page: https://doi.org/10.54022/shsv6n4-020

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PDF URL: https://ojs.studiespublicacoes.com.br/ojs/index.php/shs/article/download/21275/11737

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