Rab5a suppresses autophagy to promote drug resistance in cancer cells. Article Swipe
Wenxia Xu
,
Qiqi Shi
,
Xiaoling Qian
,
Bingluo Zhou
,
Jinye Xu
,
Liyuan Zhu
,
Lifeng Feng
,
Hongchuan Jin
,
Xian Wang
·
YOU?
·
· 2018
· Open Access
·
YOU?
·
· 2018
· Open Access
·
Cancers are huge problems that need to be investigated thoroughly. Rab5a plays an important part in the regulation of intracellular membrane trafficking. However, its role in cancer and autophagy has not been fully determined. In this study, we analyzed the correlation between Rab5a expression and patients' prognosis and then explored the effect of Rab5a knockdown on different cell lines using western blotting and fluorescence. Our results showed that up-regulated Rab5a positively correlated with the prognosis of gastric cancer patients. After knocking down Rab5a, mTOR activity was inhibited and autophagy flux increased. We also found that in our cisplatin-resistant cells, knockdown of Rab5a activated autophagy via mTOR pathway and could reverse drug resistance while overexpression of Rab5a in drug sensitive cells increased drug tolerance. In conclusion, our study demonstrates that Rab5a can suppress autophagy through mTOR and promote drug resistance in gastric cancer cells.
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- Type
- article
- Language
- en
- Landing Page
- https://pubmed.ncbi.nlm.nih.gov/29736216
- OA Status
- green
- Cited By
- 17
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3009269654
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3009269654Canonical identifier for this work in OpenAlex
- Title
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Rab5a suppresses autophagy to promote drug resistance in cancer cells.Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2018Year of publication
- Publication date
-
2018-01-01Full publication date if available
- Authors
-
Wenxia Xu, Qiqi Shi, Xiaoling Qian, Bingluo Zhou, Jinye Xu, Liyuan Zhu, Lifeng Feng, Hongchuan Jin, Xian WangList of authors in order
- Landing page
-
https://pubmed.ncbi.nlm.nih.gov/29736216Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/5934582Direct OA link when available
- Concepts
-
Autophagy, Gene knockdown, PI3K/AKT/mTOR pathway, Drug resistance, Cancer research, Cancer, Cancer cell, Cisplatin, Intracellular, Blot, Biology, Drug, Cell culture, Pharmacology, Cell biology, Medicine, Apoptosis, Gene, Signal transduction, Genetics, ChemotherapyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
17Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 2, 2022: 2, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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30Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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