Radiation-Detoxified Form of Endotoxin Effectively Activates Th1 Responses and Attenuates Ragweed-Induced Th2-Type Airway Inflammation in Mice Article Swipe
Attila Bácsi
,
Beatrix Ágics
,
Kitti Pázmándi
,
Béla Kocsis
,
Viktor Sándor
,
L Bertók
,
Géza Bruckner
,
Sándor Sipka
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25031581
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25031581
Urbanization with reduced microbial exposure is associated with an increased burden of asthma and atopic symptoms. Conversely, environmental exposure to endotoxins in childhood can protect against the development of allergies. Our study aimed to investigate whether the renaturation of the indoor environment with aerosolized radiation-detoxified lipopolysaccharide (RD-LPS) has a preventative effect against the development of ragweed-induced Th2-type airway inflammation. To explore this, cages of six-week-old BALB/c mice were treated daily with aerosolized native LPS (N-LPS) or RD-LPS. After a 10-week treatment period, mice were sensitized and challenged with ragweed pollen extract, and inflammatory cell infiltration into the airways was observed. As dendritic cells (DCs) play a crucial role in the polarization of T-cell responses, in our in vitro experiments, the effects of N-LPS and RD-LPS were compared on human monocyte-derived DCs (moDCs). Mice in RD-LPS-rich milieu developed significantly less allergic airway inflammation than mice in N-LPS-rich or common environments. The results of our in vitro experiments demonstrate that RD-LPS-exposed moDCs have a higher Th1-polarizing capacity than moDCs exposed to N-LPS. Consequently, we suppose that the aerosolized, non-toxic RD-LPS applied in early life for the renaturation of urban indoors may be suitable for the prevention of Th2-mediated allergies in childhood.
Related Topics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms25031581
- https://www.mdpi.com/1422-0067/25/3/1581/pdf?version=1706335558
- OA Status
- gold
- Cited By
- 1
- References
- 113
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391317473
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4391317473Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms25031581Digital Object Identifier
- Title
-
Radiation-Detoxified Form of Endotoxin Effectively Activates Th1 Responses and Attenuates Ragweed-Induced Th2-Type Airway Inflammation in MiceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-27Full publication date if available
- Authors
-
Attila Bácsi, Beatrix Ágics, Kitti Pázmándi, Béla Kocsis, Viktor Sándor, L Bertók, Géza Bruckner, Sándor SipkaList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms25031581Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/25/3/1581/pdf?version=1706335558Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/25/3/1581/pdf?version=1706335558Direct OA link when available
- Concepts
-
Ragweed, Lipopolysaccharide, Immunology, Inflammation, Allergy, Medicine, Immune system, MonocyteTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
113Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4391317473 |
|---|---|
| doi | https://doi.org/10.3390/ijms25031581 |
| ids.doi | https://doi.org/10.3390/ijms25031581 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38338861 |
| ids.openalex | https://openalex.org/W4391317473 |
| fwci | 0.7563153 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D051379 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Mice |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D006801 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Humans |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D000818 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Animals |
| mesh[3].qualifier_ui | Q000494 |
| mesh[3].descriptor_ui | D004731 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | pharmacology |
| mesh[3].descriptor_name | Endotoxins |
| mesh[4].qualifier_ui | Q000494 |
| mesh[4].descriptor_ui | D008070 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | pharmacology |
| mesh[4].descriptor_name | Lipopolysaccharides |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D031164 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Ambrosia |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D018418 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Th2 Cells |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D006967 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Hypersensitivity |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D007249 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Inflammation |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D008807 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Mice, Inbred BALB C |
| mesh[10].qualifier_ui | Q000494 |
| mesh[10].descriptor_ui | D010047 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | pharmacology |
| mesh[10].descriptor_name | Ovalbumin |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D003713 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Dendritic Cells |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D051379 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Mice |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D006801 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Humans |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D000818 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Animals |
| mesh[15].qualifier_ui | Q000494 |
| mesh[15].descriptor_ui | D004731 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | pharmacology |
| mesh[15].descriptor_name | Endotoxins |
| mesh[16].qualifier_ui | Q000494 |
| mesh[16].descriptor_ui | D008070 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | pharmacology |
| mesh[16].descriptor_name | Lipopolysaccharides |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D031164 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Ambrosia |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D018418 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Th2 Cells |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D006967 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Hypersensitivity |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D007249 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Inflammation |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D008807 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Mice, Inbred BALB C |
| mesh[22].qualifier_ui | Q000494 |
| mesh[22].descriptor_ui | D010047 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | pharmacology |
| mesh[22].descriptor_name | Ovalbumin |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D003713 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Dendritic Cells |
| type | article |
| title | Radiation-Detoxified Form of Endotoxin Effectively Activates Th1 Responses and Attenuates Ragweed-Induced Th2-Type Airway Inflammation in Mice |
| biblio.issue | 3 |
| biblio.volume | 25 |
| biblio.last_page | 1581 |
| biblio.first_page | 1581 |
| topics[0].id | https://openalex.org/T10051 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9969000220298767 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2737 |
| topics[0].subfield.display_name | Physiology |
| topics[0].display_name | Asthma and respiratory diseases |
| topics[1].id | https://openalex.org/T11002 |
| topics[1].field.id | https://openalex.org/fields/23 |
| topics[1].field.display_name | Environmental Science |
| topics[1].score | 0.9921000003814697 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2307 |
| topics[1].subfield.display_name | Health, Toxicology and Mutagenesis |
| topics[1].display_name | Indoor Air Quality and Microbial Exposure |
| topics[2].id | https://openalex.org/T10190 |
| topics[2].field.id | https://openalex.org/fields/23 |
| topics[2].field.display_name | Environmental Science |
| topics[2].score | 0.9894000291824341 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2307 |
| topics[2].subfield.display_name | Health, Toxicology and Mutagenesis |
| topics[2].display_name | Air Quality and Health Impacts |
| is_xpac | False |
| apc_list.value | 2300 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2490 |
| apc_paid.value | 2300 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2490 |
| concepts[0].id | https://openalex.org/C2780931586 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7986024618148804 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q844270 |
| concepts[0].display_name | Ragweed |
| concepts[1].id | https://openalex.org/C2778754761 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7760536074638367 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q421804 |
| concepts[1].display_name | Lipopolysaccharide |
| concepts[2].id | https://openalex.org/C203014093 |
| concepts[2].level | 1 |
| concepts[2].score | 0.6603906154632568 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[2].display_name | Immunology |
| concepts[3].id | https://openalex.org/C2776914184 |
| concepts[3].level | 2 |
| concepts[3].score | 0.655602216720581 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[3].display_name | Inflammation |
| concepts[4].id | https://openalex.org/C207480886 |
| concepts[4].level | 2 |
| concepts[4].score | 0.6395120620727539 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q42982 |
| concepts[4].display_name | Allergy |
| concepts[5].id | https://openalex.org/C71924100 |
| concepts[5].level | 0 |
| concepts[5].score | 0.51178377866745 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[5].display_name | Medicine |
| concepts[6].id | https://openalex.org/C8891405 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4258815050125122 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[6].display_name | Immune system |
| concepts[7].id | https://openalex.org/C2781184567 |
| concepts[7].level | 2 |
| concepts[7].score | 0.41446298360824585 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q107244 |
| concepts[7].display_name | Monocyte |
| keywords[0].id | https://openalex.org/keywords/ragweed |
| keywords[0].score | 0.7986024618148804 |
| keywords[0].display_name | Ragweed |
| keywords[1].id | https://openalex.org/keywords/lipopolysaccharide |
| keywords[1].score | 0.7760536074638367 |
| keywords[1].display_name | Lipopolysaccharide |
| keywords[2].id | https://openalex.org/keywords/immunology |
| keywords[2].score | 0.6603906154632568 |
| keywords[2].display_name | Immunology |
| keywords[3].id | https://openalex.org/keywords/inflammation |
| keywords[3].score | 0.655602216720581 |
| keywords[3].display_name | Inflammation |
| keywords[4].id | https://openalex.org/keywords/allergy |
| keywords[4].score | 0.6395120620727539 |
| keywords[4].display_name | Allergy |
| keywords[5].id | https://openalex.org/keywords/medicine |
| keywords[5].score | 0.51178377866745 |
| keywords[5].display_name | Medicine |
| keywords[6].id | https://openalex.org/keywords/immune-system |
| keywords[6].score | 0.4258815050125122 |
| keywords[6].display_name | Immune system |
| keywords[7].id | https://openalex.org/keywords/monocyte |
| keywords[7].score | 0.41446298360824585 |
| keywords[7].display_name | Monocyte |
| language | en |
| locations[0].id | doi:10.3390/ijms25031581 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S10623703 |
| locations[0].source.issn | 1422-0067, 1661-6596 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1422-0067 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | International Journal of Molecular Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1422-0067/25/3/1581/pdf?version=1706335558 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | International Journal of Molecular Sciences |
| locations[0].landing_page_url | https://doi.org/10.3390/ijms25031581 |
| locations[1].id | pmid:38338861 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | International journal of molecular sciences |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38338861 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10855154 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10855154/pdf/ijms-25-01581.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Int J Mol Sci |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10855154 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5090781260 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-2311-2975 |
| authorships[0].author.display_name | Attila Bácsi |
| authorships[0].countries | HU |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I132735039 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary |
| authorships[0].institutions[0].id | https://openalex.org/I132735039 |
| authorships[0].institutions[0].ror | https://ror.org/02xf66n48 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I132735039 |
| authorships[0].institutions[0].country_code | HU |
| authorships[0].institutions[0].display_name | University of Debrecen |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Attila Bácsi |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary |
| authorships[1].author.id | https://openalex.org/A5002561236 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Beatrix Ágics |
| authorships[1].countries | HU |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I132735039 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I132735039 |
| authorships[1].affiliations[1].raw_affiliation_string | Doctoral School of Molecular Cell and Immune Biology, University of Debrecen, H-4032 Debrecen, Hungary |
| authorships[1].institutions[0].id | https://openalex.org/I132735039 |
| authorships[1].institutions[0].ror | https://ror.org/02xf66n48 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I132735039 |
| authorships[1].institutions[0].country_code | HU |
| authorships[1].institutions[0].display_name | University of Debrecen |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Beatrix Ágics |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary, Doctoral School of Molecular Cell and Immune Biology, University of Debrecen, H-4032 Debrecen, Hungary |
| authorships[2].author.id | https://openalex.org/A5083346480 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-7709-6707 |
| authorships[2].author.display_name | Kitti Pázmándi |
| authorships[2].countries | HU |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I132735039 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary |
| authorships[2].institutions[0].id | https://openalex.org/I132735039 |
| authorships[2].institutions[0].ror | https://ror.org/02xf66n48 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I132735039 |
| authorships[2].institutions[0].country_code | HU |
| authorships[2].institutions[0].display_name | University of Debrecen |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Kitti Pázmándi |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary |
| authorships[3].author.id | https://openalex.org/A5039207307 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-7067-7055 |
| authorships[3].author.display_name | Béla Kocsis |
| authorships[3].countries | HU |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I79741316 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, H-7624 Pécs, Hungary |
| authorships[3].institutions[0].id | https://openalex.org/I79741316 |
| authorships[3].institutions[0].ror | https://ror.org/037b5pv06 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I79741316 |
| authorships[3].institutions[0].country_code | HU |
| authorships[3].institutions[0].display_name | University of Pecs |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Béla Kocsis |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, H-7624 Pécs, Hungary |
| authorships[4].author.id | https://openalex.org/A5022547607 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-8839-2648 |
| authorships[4].author.display_name | Viktor Sándor |
| authorships[4].countries | HU |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I79741316 |
| authorships[4].affiliations[0].raw_affiliation_string | Institute of Bioanalysis, Medical School and Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary |
| authorships[4].institutions[0].id | https://openalex.org/I79741316 |
| authorships[4].institutions[0].ror | https://ror.org/037b5pv06 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I79741316 |
| authorships[4].institutions[0].country_code | HU |
| authorships[4].institutions[0].display_name | University of Pecs |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Viktor Sándor |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Institute of Bioanalysis, Medical School and Szentágothai Research Center, University of Pécs, H-7624 Pécs, Hungary |
| authorships[5].author.id | https://openalex.org/A5081003121 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | L Bertók |
| authorships[5].countries | HU |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210144226 |
| authorships[5].affiliations[0].raw_affiliation_string | National Research Directorate for Radiobiology and Radiohygiene, National Public Health Center, H-1221 Budapest, Hungary |
| authorships[5].institutions[0].id | https://openalex.org/I4210144226 |
| authorships[5].institutions[0].ror | https://ror.org/04bxc4617 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210144226 |
| authorships[5].institutions[0].country_code | HU |
| authorships[5].institutions[0].display_name | Frédéric Joliot-Curie National Research Institute for Radiobiology and Radiohygiene |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Lóránd Bertók |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | National Research Directorate for Radiobiology and Radiohygiene, National Public Health Center, H-1221 Budapest, Hungary |
| authorships[6].author.id | https://openalex.org/A5112196821 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Géza Bruckner |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I143302722 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY 40536, USA |
| authorships[6].institutions[0].id | https://openalex.org/I143302722 |
| authorships[6].institutions[0].ror | https://ror.org/02k3smh20 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I143302722 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | University of Kentucky |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Geza Bruckner |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY 40536, USA |
| authorships[7].author.id | https://openalex.org/A5033870994 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-6979-8426 |
| authorships[7].author.display_name | Sándor Sipka |
| authorships[7].countries | HU |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I132735039 |
| authorships[7].affiliations[0].raw_affiliation_string | Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary |
| authorships[7].institutions[0].id | https://openalex.org/I132735039 |
| authorships[7].institutions[0].ror | https://ror.org/02xf66n48 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I132735039 |
| authorships[7].institutions[0].country_code | HU |
| authorships[7].institutions[0].display_name | University of Debrecen |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Sándor Sipka |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1422-0067/25/3/1581/pdf?version=1706335558 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Radiation-Detoxified Form of Endotoxin Effectively Activates Th1 Responses and Attenuates Ragweed-Induced Th2-Type Airway Inflammation in Mice |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10051 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9969000220298767 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2737 |
| primary_topic.subfield.display_name | Physiology |
| primary_topic.display_name | Asthma and respiratory diseases |
| related_works | https://openalex.org/W1989689414, https://openalex.org/W2405036654, https://openalex.org/W2378135992, https://openalex.org/W2411544818, https://openalex.org/W994799825, https://openalex.org/W2040079748, https://openalex.org/W2081444644, https://openalex.org/W2167861568, https://openalex.org/W121783050, https://openalex.org/W2466387589 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | doi:10.3390/ijms25031581 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S10623703 |
| best_oa_location.source.issn | 1422-0067, 1661-6596 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1422-0067 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | International Journal of Molecular Sciences |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1422-0067/25/3/1581/pdf?version=1706335558 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | International Journal of Molecular Sciences |
| best_oa_location.landing_page_url | https://doi.org/10.3390/ijms25031581 |
| primary_location.id | doi:10.3390/ijms25031581 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S10623703 |
| primary_location.source.issn | 1422-0067, 1661-6596 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1422-0067 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | International Journal of Molecular Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1422-0067/25/3/1581/pdf?version=1706335558 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | International Journal of Molecular Sciences |
| primary_location.landing_page_url | https://doi.org/10.3390/ijms25031581 |
| publication_date | 2024-01-27 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4367174790, https://openalex.org/W2117480080, https://openalex.org/W2161853794, https://openalex.org/W2152259491, https://openalex.org/W2026732025, https://openalex.org/W4283703746, https://openalex.org/W4308459044, https://openalex.org/W1539269559, https://openalex.org/W4281670155, https://openalex.org/W2908624014, https://openalex.org/W4200339607, https://openalex.org/W3000121253, https://openalex.org/W6649767774, https://openalex.org/W1991628820, https://openalex.org/W2154999612, https://openalex.org/W2028196782, https://openalex.org/W2149274167, https://openalex.org/W2133894777, https://openalex.org/W2146468044, https://openalex.org/W2066718029, https://openalex.org/W1600500540, https://openalex.org/W2170465378, https://openalex.org/W2070479807, https://openalex.org/W2019343358, https://openalex.org/W1985605588, https://openalex.org/W2133391577, https://openalex.org/W2570227268, https://openalex.org/W3021992450, https://openalex.org/W3134576276, https://openalex.org/W2057821639, https://openalex.org/W3195455916, https://openalex.org/W4310589174, https://openalex.org/W3198851663, https://openalex.org/W2116174832, https://openalex.org/W2884138484, https://openalex.org/W3111709695, https://openalex.org/W2160418158, https://openalex.org/W6706346936, https://openalex.org/W2053527919, https://openalex.org/W1985048571, https://openalex.org/W2006181371, https://openalex.org/W4383709904, https://openalex.org/W6804823484, https://openalex.org/W1487666073, https://openalex.org/W1964157161, https://openalex.org/W6642010029, https://openalex.org/W2021275181, https://openalex.org/W2411913141, https://openalex.org/W2152044788, https://openalex.org/W1939850337, https://openalex.org/W2103644250, https://openalex.org/W1977945339, https://openalex.org/W2112415662, https://openalex.org/W2158591358, https://openalex.org/W2104942758, https://openalex.org/W2054766392, https://openalex.org/W3033208992, https://openalex.org/W1768515342, https://openalex.org/W2127934565, https://openalex.org/W2084064087, https://openalex.org/W2060209413, https://openalex.org/W2044999271, https://openalex.org/W6683017398, https://openalex.org/W4225690938, https://openalex.org/W2968958832, https://openalex.org/W3088703657, https://openalex.org/W1548322053, https://openalex.org/W2171774741, https://openalex.org/W6629415278, https://openalex.org/W4306810825, https://openalex.org/W4375862682, https://openalex.org/W2074180829, https://openalex.org/W2962926163, https://openalex.org/W2017204779, https://openalex.org/W4300698595, https://openalex.org/W2155510706, https://openalex.org/W2792797672, https://openalex.org/W4225844329, https://openalex.org/W2405758607, https://openalex.org/W2161074777, https://openalex.org/W1494254017, https://openalex.org/W2790463169, https://openalex.org/W1972473113, https://openalex.org/W1634854084, https://openalex.org/W4224009742, https://openalex.org/W2042144868, https://openalex.org/W2047422716, https://openalex.org/W2131490293, https://openalex.org/W1925993589, https://openalex.org/W2071804009, https://openalex.org/W2993940392, https://openalex.org/W2409634272, https://openalex.org/W2033275369, https://openalex.org/W3106692639, https://openalex.org/W2359704490, https://openalex.org/W4319444635, https://openalex.org/W1989961245, https://openalex.org/W6716525377, https://openalex.org/W6677570699, https://openalex.org/W2038407645, https://openalex.org/W2045710956, https://openalex.org/W2156426437, https://openalex.org/W2009392624, https://openalex.org/W2140288306, https://openalex.org/W1489367242, https://openalex.org/W3201255943, https://openalex.org/W2124897411, https://openalex.org/W1974097104, https://openalex.org/W1966882279, https://openalex.org/W4226523361, https://openalex.org/W2416727508, https://openalex.org/W4200609760, https://openalex.org/W1996090623 |
| referenced_works_count | 113 |
| abstract_inverted_index.a | 48, 78, 105, 161 |
| abstract_inverted_index.As | 100 |
| abstract_inverted_index.To | 59 |
| abstract_inverted_index.an | 8 |
| abstract_inverted_index.be | 189 |
| abstract_inverted_index.in | 21, 108, 114, 116, 133, 144, 153, 179, 197 |
| abstract_inverted_index.is | 5 |
| abstract_inverted_index.of | 11, 28, 38, 54, 63, 111, 121, 151, 185, 194 |
| abstract_inverted_index.on | 127 |
| abstract_inverted_index.or | 75, 146 |
| abstract_inverted_index.to | 19, 33, 168 |
| abstract_inverted_index.we | 171 |
| abstract_inverted_index.DCs | 130 |
| abstract_inverted_index.LPS | 73 |
| abstract_inverted_index.Our | 30 |
| abstract_inverted_index.The | 149 |
| abstract_inverted_index.and | 13, 85, 91, 123 |
| abstract_inverted_index.can | 23 |
| abstract_inverted_index.for | 182, 191 |
| abstract_inverted_index.has | 47 |
| abstract_inverted_index.may | 188 |
| abstract_inverted_index.our | 115, 152 |
| abstract_inverted_index.the | 26, 36, 39, 52, 96, 109, 119, 174, 183, 192 |
| abstract_inverted_index.was | 98 |
| abstract_inverted_index.Mice | 132 |
| abstract_inverted_index.cell | 93 |
| abstract_inverted_index.have | 160 |
| abstract_inverted_index.into | 95 |
| abstract_inverted_index.less | 138 |
| abstract_inverted_index.life | 181 |
| abstract_inverted_index.mice | 66, 82, 143 |
| abstract_inverted_index.play | 104 |
| abstract_inverted_index.role | 107 |
| abstract_inverted_index.than | 142, 165 |
| abstract_inverted_index.that | 157, 173 |
| abstract_inverted_index.were | 67, 83, 125 |
| abstract_inverted_index.with | 1, 7, 42, 70, 87 |
| abstract_inverted_index.(DCs) | 103 |
| abstract_inverted_index.After | 77 |
| abstract_inverted_index.N-LPS | 122 |
| abstract_inverted_index.aimed | 32 |
| abstract_inverted_index.cages | 62 |
| abstract_inverted_index.cells | 102 |
| abstract_inverted_index.daily | 69 |
| abstract_inverted_index.early | 180 |
| abstract_inverted_index.human | 128 |
| abstract_inverted_index.moDCs | 159, 166 |
| abstract_inverted_index.study | 31 |
| abstract_inverted_index.this, | 61 |
| abstract_inverted_index.urban | 186 |
| abstract_inverted_index.vitro | 117, 154 |
| abstract_inverted_index.BALB/c | 65 |
| abstract_inverted_index.N-LPS. | 169 |
| abstract_inverted_index.RD-LPS | 124, 177 |
| abstract_inverted_index.T-cell | 112 |
| abstract_inverted_index.airway | 57, 140 |
| abstract_inverted_index.asthma | 12 |
| abstract_inverted_index.atopic | 14 |
| abstract_inverted_index.burden | 10 |
| abstract_inverted_index.common | 147 |
| abstract_inverted_index.effect | 50 |
| abstract_inverted_index.higher | 162 |
| abstract_inverted_index.indoor | 40 |
| abstract_inverted_index.milieu | 135 |
| abstract_inverted_index.native | 72 |
| abstract_inverted_index.pollen | 89 |
| abstract_inverted_index.(N-LPS) | 74 |
| abstract_inverted_index.10-week | 79 |
| abstract_inverted_index.RD-LPS. | 76 |
| abstract_inverted_index.against | 25, 51 |
| abstract_inverted_index.airways | 97 |
| abstract_inverted_index.applied | 178 |
| abstract_inverted_index.crucial | 106 |
| abstract_inverted_index.effects | 120 |
| abstract_inverted_index.explore | 60 |
| abstract_inverted_index.exposed | 167 |
| abstract_inverted_index.indoors | 187 |
| abstract_inverted_index.period, | 81 |
| abstract_inverted_index.protect | 24 |
| abstract_inverted_index.ragweed | 88 |
| abstract_inverted_index.reduced | 2 |
| abstract_inverted_index.results | 150 |
| abstract_inverted_index.suppose | 172 |
| abstract_inverted_index.treated | 68 |
| abstract_inverted_index.whether | 35 |
| abstract_inverted_index.(RD-LPS) | 46 |
| abstract_inverted_index.(moDCs). | 131 |
| abstract_inverted_index.Th2-type | 56 |
| abstract_inverted_index.allergic | 139 |
| abstract_inverted_index.capacity | 164 |
| abstract_inverted_index.compared | 126 |
| abstract_inverted_index.exposure | 4, 18 |
| abstract_inverted_index.extract, | 90 |
| abstract_inverted_index.suitable | 190 |
| abstract_inverted_index.allergies | 196 |
| abstract_inverted_index.childhood | 22 |
| abstract_inverted_index.dendritic | 101 |
| abstract_inverted_index.developed | 136 |
| abstract_inverted_index.increased | 9 |
| abstract_inverted_index.microbial | 3 |
| abstract_inverted_index.non-toxic | 176 |
| abstract_inverted_index.observed. | 99 |
| abstract_inverted_index.symptoms. | 15 |
| abstract_inverted_index.treatment | 80 |
| abstract_inverted_index.N-LPS-rich | 145 |
| abstract_inverted_index.allergies. | 29 |
| abstract_inverted_index.associated | 6 |
| abstract_inverted_index.challenged | 86 |
| abstract_inverted_index.childhood. | 198 |
| abstract_inverted_index.endotoxins | 20 |
| abstract_inverted_index.prevention | 193 |
| abstract_inverted_index.responses, | 113 |
| abstract_inverted_index.sensitized | 84 |
| abstract_inverted_index.Conversely, | 16 |
| abstract_inverted_index.RD-LPS-rich | 134 |
| abstract_inverted_index.aerosolized | 43, 71 |
| abstract_inverted_index.demonstrate | 156 |
| abstract_inverted_index.development | 27, 53 |
| abstract_inverted_index.environment | 41 |
| abstract_inverted_index.experiments | 155 |
| abstract_inverted_index.investigate | 34 |
| abstract_inverted_index.Th2-mediated | 195 |
| abstract_inverted_index.Urbanization | 0 |
| abstract_inverted_index.aerosolized, | 175 |
| abstract_inverted_index.experiments, | 118 |
| abstract_inverted_index.infiltration | 94 |
| abstract_inverted_index.inflammation | 141 |
| abstract_inverted_index.inflammatory | 92 |
| abstract_inverted_index.polarization | 110 |
| abstract_inverted_index.preventative | 49 |
| abstract_inverted_index.renaturation | 37, 184 |
| abstract_inverted_index.six-week-old | 64 |
| abstract_inverted_index.Consequently, | 170 |
| abstract_inverted_index.environmental | 17 |
| abstract_inverted_index.environments. | 148 |
| abstract_inverted_index.inflammation. | 58 |
| abstract_inverted_index.significantly | 137 |
| abstract_inverted_index.RD-LPS-exposed | 158 |
| abstract_inverted_index.Th1-polarizing | 163 |
| abstract_inverted_index.ragweed-induced | 55 |
| abstract_inverted_index.monocyte-derived | 129 |
| abstract_inverted_index.lipopolysaccharide | 45 |
| abstract_inverted_index.radiation-detoxified | 44 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5033870994 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I132735039 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/11 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Sustainable cities and communities |
| citation_normalized_percentile.value | 0.58665892 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |