Randomized Feasibility Study Evaluating Multiple FDA-approved Microbubbles for CEUS Lymphography Article Swipe
Samuel Jang
,
Jess D. Rames
,
Gina K. Hesley
,
Nathan Brinkman
,
Nho V. Tran
,
Vahe Fahradyan
,
Christine U. Lee
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1097/gox.0000000000005985
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1097/gox.0000000000005985
Summary: Prior studies on contrast-enhanced ultrasound (CEUS) lymphography for preoperative mapping before lymphaticovenous anastomosis surgery in patients with extremity lymphedema have been limited to using only Lumason and Sonazoid as microbubble contrast agents. The purpose of this study was to determine the feasibility of using two other Food & Drug Administration–approved microbubble agents, Optison and Definity, for imaging lymphatic vessels in the upper extremities. Nine female adults with unilateral upper extremity lymphedema anticipating lymphaticovenous anastomosis surgery underwent CEUS lymphography of the unaffected upper extremity randomized to either Lumason, Definity, or Optison. Lymphatic vessels were visualized in all but one case when undilated Definity was used. In the eight upper extremities where lymphatic vessels were visualized, an average of eight intradermal injections of microbubbles were performed in the extremity. Lymphatic vessels could be identified in 57% (36 of 63) of the injections. The effective dilution for each of the microbubble agents is provided. This was the first successful demonstration of lymphatic vessel visualization using either Definity or Optison. Broadening the range of available microbubble agents for CEUS lymphography could improve accessibility to the procedure and provide potentially safer alternatives.
Related Topics
Concepts
Medicine
Microbubbles
Lymphatic system
Lymphedema
Radiology
Anastomosis
Ultrasound
Lymphatic vessel
Contrast-enhanced ultrasound
Surgery
Pathology
Internal medicine
Cancer
Breast cancer
Metastasis
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/gox.0000000000005985
- OA Status
- gold
- Cited By
- 2
- References
- 10
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400736864
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400736864Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/gox.0000000000005985Digital Object Identifier
- Title
-
Randomized Feasibility Study Evaluating Multiple FDA-approved Microbubbles for CEUS LymphographyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-07-01Full publication date if available
- Authors
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Samuel Jang, Jess D. Rames, Gina K. Hesley, Nathan Brinkman, Nho V. Tran, Vahe Fahradyan, Christine U. LeeList of authors in order
- Landing page
-
https://doi.org/10.1097/gox.0000000000005985Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1097/gox.0000000000005985Direct OA link when available
- Concepts
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Medicine, Microbubbles, Lymphatic system, Lymphedema, Radiology, Anastomosis, Ultrasound, Lymphatic vessel, Contrast-enhanced ultrasound, Surgery, Pathology, Internal medicine, Cancer, Breast cancer, MetastasisTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
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10Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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