Rapid cell turnover to model adipocyte size distribution Article Swipe
Louis Fostier
,
A. Dauger
,
Romain Yvinec
,
Magali Ribot
,
Chloé Audebert
,
Hédi Soula
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jtbi.2025.112311
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jtbi.2025.112311
White adipose tissue, composed of adipocyte cells, primarily stores energy as lipid droplets. The size of adipocytes varies significantly within the tissue according to the amount of stored lipids. A striking observation is that the adipocyte size distribution is bimodal, and thus, this tissue is lacking a characteristic size. We propose a novel dynamical model, based on a partial differential equation, to represent the adipocyte size distribution. The model assumes continuous adipocyte growth, with a velocity dependent on cell radius and extracellular lipid availability, together with constant rates of cell recruitment and death. We prove the existence and local stability of a unique stationary solution for a broad range of growth velocity functions. Choosing a parcimonious formulation, we show that only three parameters are enough to describe adipocyte size distributions measurements in rats. These parameters are robustly estimated through approximate Bayesian computation, and the model demonstrates excellent agreement with experimental data. This mechanistic, three-parameter framework offers a new and interpretable approach to characterizing adipocyte size distributions.
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- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jtbi.2025.112311
- OA Status
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- OpenAlex ID
- https://openalex.org/W4414896462
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https://doi.org/10.1016/j.jtbi.2025.112311Digital Object Identifier
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Rapid cell turnover to model adipocyte size distributionWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-11-11Full publication date if available
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Louis Fostier, A. Dauger, Romain Yvinec, Magali Ribot, Chloé Audebert, Hédi SoulaList of authors in order
- Landing page
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https://doi.org/10.1016/j.jtbi.2025.112311Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.jtbi.2025.112311Direct OA link when available
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