Rapid induction and long-term self-renewal of neural crest-derived ectodermal chondrogenic cells from hPSCs Article Swipe
Pei Shen
,
Lu Chen
,
Dahe Zhang
,
Simo Xia
,
Zhuman Lv
,
Duohong Zou
,
Zhiyuan Zhang
,
Chi Yang
,
Wenlin Li
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1038/s41536-022-00265-0
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1038/s41536-022-00265-0
Articular cartilage is highly specific and has limited capacity for regeneration if damaged. Human pluripotent stem cells (hPSCs) have the potential to generate any cell type in the body. Here, we report the dual-phase induction of ectodermal chondrogenic cells (ECCs) from hPSCs through the neural crest (NC). ECCs were able to self-renew long-term (over numerous passages) in a cocktail of growth factors and small molecules. The cells stably expressed cranial neural crest-derived mandibular condylar cartilage markers, such as MSX1, FOXC1 and FOXC2. Compared with chondroprogenitors from iPSCs via the paraxial mesoderm, ECCs had single-cell transcriptome profiles similar to condylar chondrocytes. After the removal of the cocktail sustaining self-renewal, the cells stopped proliferating and differentiated into a homogenous chondrocyte population. Remarkably, after transplantation, this cell lineage was able to form cartilage-like structures resembling mandibular condylar cartilage in vivo. This finding provides a framework to generate self-renewing cranial chondrogenic progenitors, which could be useful for developing cell-based therapy for cranial cartilage injury.
Related Topics
Concepts
Chondrogenesis
Cranial neural crest
Neural crest
Induced pluripotent stem cell
Biology
Cartilage
Cell biology
Anatomy
Chondrocyte
Stem cell
Progenitor cell
Embryo
Embryonic stem cell
Genetics
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41536-022-00265-0
- https://www.nature.com/articles/s41536-022-00265-0.pdf
- OA Status
- gold
- Cited By
- 6
- References
- 75
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4311287565
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4311287565Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41536-022-00265-0Digital Object Identifier
- Title
-
Rapid induction and long-term self-renewal of neural crest-derived ectodermal chondrogenic cells from hPSCsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-12-08Full publication date if available
- Authors
-
Pei Shen, Lu Chen, Dahe Zhang, Simo Xia, Zhuman Lv, Duohong Zou, Zhiyuan Zhang, Chi Yang, Wenlin LiList of authors in order
- Landing page
-
https://doi.org/10.1038/s41536-022-00265-0Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41536-022-00265-0.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41536-022-00265-0.pdfDirect OA link when available
- Concepts
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Chondrogenesis, Cranial neural crest, Neural crest, Induced pluripotent stem cell, Biology, Cartilage, Cell biology, Anatomy, Chondrocyte, Stem cell, Progenitor cell, Embryo, Embryonic stem cell, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2024: 3, 2023: 3Per-year citation counts (last 5 years)
- References (count)
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75Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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