Rapid toxin sequestration modifies poison frog physiology Article Swipe
Lauren A. O’Connell
,
Jeremy D. O’Connell
,
João A. Paulo
,
Sunia A. Trauger
,
Steven P. Gygi
,
Andrew W. Murray
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1242/jeb.230342
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1242/jeb.230342
Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog (Oophaga sylvatica) to determine how quickly alkaloids are accumulated and how toxins modify frog physiology using quantitative proteomics. Diablito frogs rapidly accumulated the alkaloid decahydroquinoline within 4 days, and dietary alkaloid exposure altered protein abundance in the intestines, liver and skin. Many proteins that increased in abundance with decahydroquinoline accumulation are plasma glycoproteins, including the complement system and the toxin-binding protein saxiphilin. Other protein classes that change in abundance with decahydroquinoline accumulation are membrane proteins involved in small molecule transport and metabolism. Overall, this work shows that poison frogs can rapidly accumulate alkaloids, which alter carrier protein abundance, initiate an immune response, and alter small molecule transport and metabolism dynamics across tissues.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1242/jeb.230342
- https://journals.biologists.com/jeb/article-pdf/224/3/jeb230342/1816670/jeb230342.pdf
- OA Status
- bronze
- Cited By
- 32
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3119938102
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3119938102Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1242/jeb.230342Digital Object Identifier
- Title
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Rapid toxin sequestration modifies poison frog physiologyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-06Full publication date if available
- Authors
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Lauren A. O’Connell, Jeremy D. O’Connell, João A. Paulo, Sunia A. Trauger, Steven P. Gygi, Andrew W. MurrayList of authors in order
- Landing page
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https://doi.org/10.1242/jeb.230342Publisher landing page
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https://journals.biologists.com/jeb/article-pdf/224/3/jeb230342/1816670/jeb230342.pdfDirect link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://journals.biologists.com/jeb/article-pdf/224/3/jeb230342/1816670/jeb230342.pdfDirect OA link when available
- Concepts
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Biology, Alkaloid, Chemical defense, Toxin, Plant litter, Abundance (ecology), Metabolism, Ecology, Biochemistry, Botany, Herbivore, EcosystemTop concepts (fields/topics) attached by OpenAlex
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32Total citation count in OpenAlex
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2025: 3, 2024: 4, 2023: 9, 2022: 11, 2021: 3Per-year citation counts (last 5 years)
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46Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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