Rate of Egfr Mutation Testing for Patients with Nonsquamous Non-Small-Cell Lung Cancer with Implementation of Reflex Testing by Pathologists Article Swipe
Parneet Cheema
,
Simon Raphael
,
Robert H. El-Maraghi
,
Jia-Xin Li
,
Rebecca F. McClure
,
L. Zibdawi
,
A. Chan
,
J. Charles Victor
,
Aastha Dolley
,
Alison Dziarmaga
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3747/co.24.3266
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3747/co.24.3266
Background: Testing for mutation of the EGFR (epidermal growth factor receptor) gene is a standard of care for patients with advanced nonsquamous non-small-cell lung cancer (nsclc). To improve timely access to EGFR results, a few centres implemented reflex testing, defined as a request for EGFR testing by the pathologist at the time of a nonsquamous nsclc diagnosis. We evaluated the impact of reflex testing on EGFR testing rates. Methods: A retrospective observational review of the Web-based AstraZeneca Canada EGFR Database from 1 April 2010 to 31 March 2014 found centres within Ontario that had requested EGFR testing through the database and that had implemented reflex testing (with at least 2 years’ worth of data, including the pre- and post-implementation period). Results: The 7 included centres had requested EGFR tests for 2214 patients. The proportion of pathologists requesting EGFR tests increased after implementation of reflex testing (53% vs. 4%); conversely, the proportion of medical oncologists requesting tests decreased (46% vs. 95%, p < 0.001). After implementation of reflex testing, the mean number of patients having EGFR testing per centre per month increased significantly [12.6 vs. 4.9 (range: 4.5–14.9), p < 0.001]. Before reflex testing, EGFR testing rates showed a significant monthly increase over time (1.37 more tests per month; 95% confidence interval: 1.19 to 1.55 tests; p < 0.001). That trend could not account for the observed increase with reflex testing, because an immediate increase in EGFR test requests was observed with the introduction of reflex testing (p = 0.003), and the overall trend was sustained throughout the post–reflex testing period (p < 0.001). Conclusions: Reflex EGFR testing for patients with nonsquamous nsclc was successfully implemented at multiple centres and was associated with an increase in EGFR testing.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3747/co.24.3266
- https://current-oncology.com/index.php/oncology/article/download/3266/2338
- OA Status
- gold
- Cited By
- 31
- References
- 17
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2593722736
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2593722736Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3747/co.24.3266Digital Object Identifier
- Title
-
Rate of Egfr Mutation Testing for Patients with Nonsquamous Non-Small-Cell Lung Cancer with Implementation of Reflex Testing by PathologistsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-02-01Full publication date if available
- Authors
-
Parneet Cheema, Simon Raphael, Robert H. El-Maraghi, Jia-Xin Li, Rebecca F. McClure, L. Zibdawi, A. Chan, J. Charles Victor, Aastha Dolley, Alison DziarmagaList of authors in order
- Landing page
-
https://doi.org/10.3747/co.24.3266Publisher landing page
- PDF URL
-
https://current-oncology.com/index.php/oncology/article/download/3266/2338Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://current-oncology.com/index.php/oncology/article/download/3266/2338Direct OA link when available
- Concepts
-
Medicine, Reflex, Internal medicine, Oncology, Lung cancer, Cancer, Epidermal growth factor receptor, Database, Computer scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
31Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 4, 2023: 6, 2022: 1, 2021: 9Per-year citation counts (last 5 years)
- References (count)
-
17Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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