RDF dataset produced in the work "Exploring Adverse Outcome Pathways for Nanomaterials with semantic web technologies" Article Swipe
Jeaphianne van Rijn
,
Marvin Martens
,
Ammar Ammar
,
Mihaela Roxana Cimpan
,
Valérie Fessard
,
Peter Hoet
,
Nina Jeliazkova
,
Sivakumar Murugadoss
,
Ivana Vinković Vrček
,
Egon Willighagen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.5281/zenodo.8076364
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.5281/zenodo.8076364
Adverse Outcome Pathways (AOPs) have been proposed to facilitate mechanistic understanding of interactions of chemicals/materials with biological systems. Each AOP starts with a molecular initiating event (MIE) and possibly ends with adverse outcome(s) (AOs) via a series of key events (KEs). So far, the interaction of engineered nanomaterials (ENMs) with biomolecules, biomembranes, cells, and biological structures, in general, is not yet fully elucidated. There is also a huge lack of information on which AOPs are ENMs-relevant or -specific, despite numerous published data on toxicological endpoints they trigger, such as oxidative stress and inflammation. We propose to integrate related data and knowledge recently collected. Our approach combines the annotation of nanomaterials and their MIEs with ontology annotation to demonstrate how we can then query AOPs and biological pathway information for these materials. We conclude that a FAIR (Findable, Accessible, Interoperable, Reusable) representation of the ENM-MIE knowledge simplifies integration with other knowledge.
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Concepts
Metadata
- Type
- dataset
- Language
- en
- Landing Page
- https://doi.org/10.5281/zenodo.8076364
- OA Status
- green
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393523137
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393523137Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5281/zenodo.8076364Digital Object Identifier
- Title
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RDF dataset produced in the work "Exploring Adverse Outcome Pathways for Nanomaterials with semantic web technologies"Work title
- Type
-
datasetOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-06-23Full publication date if available
- Authors
-
Jeaphianne van Rijn, Marvin Martens, Ammar Ammar, Mihaela Roxana Cimpan, Valérie Fessard, Peter Hoet, Nina Jeliazkova, Sivakumar Murugadoss, Ivana Vinković Vrček, Egon WillighagenList of authors in order
- Landing page
-
https://doi.org/10.5281/zenodo.8076364Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://doi.org/10.5281/zenodo.8076364Direct OA link when available
- Concepts
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RDF, Adverse Outcome Pathway, Semantic Web, Computer science, Outcome (game theory), SPARQL, Work (physics), World Wide Web, Data science, Engineering, Computational biology, Biology, Mathematics, Mathematical economics, Mechanical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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