European Journal of Neurology • Vol 32 • No 4
Reactive Pleocytosis After Repeated Lumbar Puncture—Implications for Clinical Practice
April 2025 • Martin Schmidauer, Fabian Föttinger, Klaus Berek, Michael Auer, Robert Barket, Franziska Di Pauli, Nik Krajnc, Laura Stichaller, Sina Zaic, Anne Zing…
ABSTRACT Introduction Lumbar puncture (LP) is a routine clinical procedure and, in some cases, is repeatedly performed for diagnostic or therapeutic reasons. The impact of repeated LP on cerebrospinal fluid (CSF) findings is not clear. Objective To investigate whether repeated LP is associated with reactive pleocytosis and disruption of blood–CSF barrier function and to determine the role of interval between repeated LP. Methods Patients with non‐inflammatory neurological disease (NIND) and at least two consecutiv…